A5070629443- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Granular flow and fluidized beds
- Geochemistry and Geologic Mapping
- X-ray Diffraction in Crystallography
- Microtubule and mitosis dynamics
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Geological and Geochemical Analysis
- Biochemical and Molecular Research
- Powder Metallurgy Techniques and Materials
- HIV Research and Treatment
- Geochemistry and Geochronology of Asian Mineral Deposits
- Crystallography and molecular interactions
- Rheology and Fluid Dynamics Studies
- Insect Resistance and Genetics
- Pharmacological Effects of Natural Compounds
- earthquake and tectonic studies
- Geomechanics and Mining Engineering
- Fluid Dynamics and Heat Transfer
- Thermodynamic properties of mixtures
- Material Dynamics and Properties
- Mineral Processing and Grinding
- Insect-Plant Interactions and Control
- Cancer therapeutics and mechanisms
Northwest A&F University
2025
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
China University of Geosciences
2016-2024
Jilin University
2024
Wuhan University
2020-2023
Renmin Hospital of Wuhan University
2020-2023
Zhengzhou University
2017-2023
Zhengzhou University of Industrial Technology
2022
Chengdu University
2021
Layer-by-layer (LbL) assembled films have been exploited for surface-mediated drug delivery. The drugs loaded in the were usually released via diffusion or degradation of one film components. Here we demonstrate that release can also be achieved by exploiting dynamic nature hydrogen-bonded LbL films. fabricated from tannic acid (TA), a model polyphenolic drug, and poly(vinyl pyrrolidone) (PVPON). driving force buildup is hydrogen bonding between two components, which was confirmed Fourier...
We investigated whether development of resistance to a Bt crop in the presence natural enemy would be slower than without and biological control, conjunction with crop, could effectively suppress pest population. Additionally, we insecticide-sprayed refuges non-Bt crops delay or accelerate crop. used system broccoli expressing Cry1Ac, population Plutella xylostella low frequency individuals resistant Cry1Ac insecticide spinosad, enemy, Coleomegilla maculata, conduct experiments over multiple...
Fluorescence imaging plays an important role in researching the biological function of lipid droplets (LDs). However, short-wave emission, tedious synthesis process and insufficient specificity have significantly limited applications commercially available probes. Herein, we prepared a novel one-step synthesized near-infrared (NIR) fluorescent probe, TNBD, with very low emission aqueous solution solid state, but enhanced fluorescence is exhibited oleic acid. Moreover, TNBD impressive droplet...
Background: Purine nucleoside phosphorylase (PNP) from Escherichia coli is a hexameric enzyme that catalyzes the reversible phosphorolysis of 6-amino and 6-oxopurine (2′-deoxy)ribonucleosides to free base (2′-deoxy)ribose-1-phosphate. In contrast, human bovine PNPs are trimeric accept only nucleosides as substrates. The difference in specificities these two enzymes has been utilized gene therapy treatments which certain prodrugs cleaved by E. PNP but not enzyme. show no similarity amino acid...
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway, which provides an alternative to de novo pathway for biosynthesis of nucleotides. PNP catalyzes reversible phosphorolysis 2'-deoxypurine ribonucleosides free bases and 2-deoxyribose 1-phosphate. Absence activity humans associated with specific T-cell immune suppression. Its role these two processes has made important drug design target. We have investigated structural details PNP-catalyzed reaction by...
N6-methyladenosine (m6A) methylation is a key epigenetic modification that can modulate gene expression and strongly affect mammalian developmental processes. However, the genome-wide of long non-coding RNAs (lncRNAs) its implications for development skeletal muscle remain poorly understood. Bovine samples from five stages were analyzed in this study to establish lncRNA methylome transcriptomic maps. Globally, 59.67% lncRNAs with m6A modifications, percentage decreased progressively during...
Phase equilibria of the “ Cu 2 O ”– Al 3 – SiO system have been experimentally investigated at metallic copper saturation. High‐temperature equilibration, rapid quenching, and electron probe X‐ray microanalysis ( EPMA ) techniques used. Containerless equilibration technique has developed to enable phase equilibrium this chemically reactive be investigated. The microstructures compositions all phases present in quenched sample were measured accurately using . isothermals between 1150°C 1300°C...
Improvements in the toughness and thermal properties without affecting other mechanical hyperbranched polyurethane modified epoxy were demonstrated.
The incorporation of counterions into amorphous solid dispersions (ASDs) has been proven to be effective for improving the dissolution rates ionizable drugs in ASDs. In this work, effect buffer pH and concentration on rate indomethacin-copovidone 40:60 (IMC-PVPVA, w/w) ASD with or without incorporated sodium hydroxide (NaOH) was studied by surface area-normalized provide further mechanistic understanding phenomenon. Buffer from 4.7 7.2 20 100 mM at 5.5 were investigated. As decreased, IMC...