A5025418749- Health, Environment, Cognitive Aging
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Eating Disorders and Behaviors
- Birth, Development, and Health
- Stress Responses and Cortisol
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Early Childhood Education and Development
- Cannabis and Cannabinoid Research
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Autoimmune Bullous Skin Diseases
- Psychosomatic Disorders and Their Treatments
- Health, psychology, and well-being
- Platelet Disorders and Treatments
- Health disparities and outcomes
- Psychotherapy Techniques and Applications
- Mental Health Treatment and Access
- Cognitive Abilities and Testing
- Erythropoietin and Anemia Treatment
- COVID-19 and Mental Health
University College London
2019-2025
Creative Commons
2022
E Ink (South Korea)
2022
Medical Research Council
2022
Sapienza University of Rome
1986-2017
University of California, San Diego
2016-2017
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
1971
Abstract Anhedonia and amotivation are debilitating symptoms represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might potential modifiable target for interventions. Based on results obtained from animal models, we tested the hypothesis that endocannabinoid system mediates association between gut-microbiome diversity anhedonia/amotivation general population cohort. We used longitudinal data collected 786 volunteer twins recruited as...
Abstract Purpose Peer victimisation, often a serious childhood stressor, has been associated with poor cognitive outcomes. The current study sought to uncover whether peer victimisation is functioning in via inflammation. Methods Data from 4583 participants the Avon Longitudinal Study of Parents and Children (ALSPAC) were analysed. Path analysis was conducted determine inflammation, measured using IL-6 CRP levels (age 9), mediates effects 8), even after controlling for other stressors, on...
Abstract This study examined whether the experience of stressors since infancy is related to executive function and social communication in late childhood via inflammation, using data from 4457 participants Avon Longitudinal Study Parents Children (ALSPAC). It explored effect stressful life events (from 6 months 8.5 years) on working memory, response inhibition, selective attention, attentional control, problems cognition (at ages 10–11 was mediated by inflammation (interleukin C‐reactive...
To explore whether paternal psychological distress is related to the longitudinal course of child problem behavior after accounting for maternal distress.We used data from Millennium Cohort Study (MCS), a large general-population birth cohort in United Kingdom. Maternal and was measured with Kessler 6-item Psychological Distress Scale (K-6) at ages 3, 5, 7, 11, 14 years. Problem Strengths Difficulties Questionnaire these ages. Data were analyzed using growth curve modeling, before adjustment...
Accuracy of risk algorithms for psychosis prediction in "at mental state" (ARMS) samples may differ according to the recruitment setting. Standardized criteria used detect ARMS individuals lack specificity if setting is a secondary health service. The authors tested modified strategy predict conversion this by using systematic selection trait-markers prodrome sample with heterogeneous status.138 non-psychotic outpatients (aged 17-31) were consecutively recruited services and followed-up up 3...
We report our results with pipobroman (PB) therapy in patients essential thrombocythemia (ET). 21 consecutive untreated were treated PB from 1975 to 1984. was given at a dose of 1 mg/kg/d until platelet count dropped below 600 X 10(9)/l. In 18 (86%) hematological remission obtained. Median duration induction phase 49 d. all cases maintenance regimen required ranging 0.2 0.5 mg/kg/d, according number. Follow-up responder ranged 6 108 months (median 17 months). Treatment well tolerated and we...
Introduction: Neurocognitive impairments have been observed in patients with bipolar disorder (BD) even during the euthymic phase of disease, potentially representing trait-associated rather than state-associated characteristics disorder. In present study, we used transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices improve neurophysiological performances BD. Methods: Twenty-five outpatients BD underwent open-label prefrontocerebellar tDCS for 3...
Overlapping neural system dysfunctions, mainly involving the secondary somatosensory cortex (S2), anterior cingulate (ACC) and insular (AIC), seem to be related both pain-perception abnormalities psychotic symptoms in schizophrenia (SCZ) bipolar disorder (BD). Laser-evoked potentials (LEPs) were used investigate central pain-processing SCZ, I (BD-I), II (BD-II), evaluate their relationship with history of psychosis, social-cognitive functional impairments.Twenty patients 17 BD-I, 21 BD-II...
The emergence of eating problems during childhood increases the risk for disorders (EDs) young adulthood. Previous studies highlight a relationship between poor self-regulation and onset pathology. In this study, we investigated whether association is mediated by decision-making difficulties.To test hypothesis, used data from Millennium Cohort Study. Decision-making performance was assessed with Cambridge Gambling Task at age 11. Principal components analysis to derive an index ED symptoms...
We report our experience with danazol in the treatment of patients refractory immune thrombocytopenic purpura (ITP). The effects this drug were investigated 10 patients, 6 males and 4 females, aged from 40 to 85 years, (median 58 years), a platelet count below 50 X 10(9)/l. had previously been treated steroids; one them also unsuccessfully splenectomized. Danazol was administered at dosage 600 mg/day for 3 months. Before after treatment, detection antiplatelet antibodies performed. Seven One...
Psychiatric disorders like eating (EDs) might be underpinned by differences in decision making. However, little previous research has investigated this potential relationship using longitudinal data. This study aimed to understand how components of making (delay aversion, risk adjustment, taking, quality and deliberation time) measured the Cambridge Gambling Task United Kingdom’s Millennium Cohort Study (MCS; n = 11,303; female 50.17%) at age 11 explain clusters/types ED prodrome involving...
Low neighbourhood cohesion and increased levels of inflammation are independent predictors psychological distress. In this study we explored if they also interact to predict it.Our sample was 9,393 adult participants the UK Household Longitudinal Study (UKHLS), a large longitudinal household panel in UK. Inflammation measured using C-reactive protein levels. Perceived 13-item questionnaire. Psychological distress with General Health Questionnaire-12.Perceived retained their significant main...
Children living in deprived areas tend to show greater problem behaviour relative children more advantaged areas. We explored the effect of different forms area deprivation (such as income, education and health) on development child (emotional behavioural problems) from early childhood middle adolescence. Using data Millennium Cohort Study, we modelled trajectories depending level neighbourhood, across ages 3 14 years, England ( n = 6,127). seven types social, economic environmental small...
In a society highly focused on physical appearance, people are increasingly using the so-called performance and image-enhancing drugs (PIEDs) or life-style as an easy way to control weight. Preliminary data from online sources (e.g. websites, drug forums, e-newsletters) suggest increased use of cannabis amongst general population PIED due its putative weight-loss properties. The and/or cannabis-related products lose weight may represent new substance-use trend that should be carefully...