A5029079426- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
University of California, San Diego
2021-2025
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-coupled receptors (GPCRs). 2-Br-LSD shows partial agonism several GPCRs, including 5-HT2A, and does not induce head-twitch response (HTR) in mice, supporting its classification a 5-HT2A agonist. Unlike LSD, lacks 5-HT2B agonism, an effect linked to cardiac...
The psychopharmacological properties of the psychedelic drug lysergic acid diethylamide (LSD) have attracted interest several generations scientists. While further explorations involving novel LSD-type compounds are needed to assess their potential as medicinal drugs, emergence derivatives recreational drugs has also been observed. 1-Valeroyl-LSD (also known 1-valeryl-LSD, 1-pentanoyl-LSD, 1V-LSD, or "Valerie") is a new N1 -acylated LSD derivative that recently appeared on online market, and...
Despite improved life expectancy of people with HIV (PWH), HIV-associated neurocognitive impairment (NCI) persists, alongside deficits in sensorimotor gating and neuroinflammation. PWH exhibit high smoking rates, possibly due to neuroprotective, anti-inflammatory, cognitive-enhancing effects nicotine, suggesting potential self-medication.