Acoustic-resolution photoacoustic micro-scopy (AR-PAM) is an emerging biomedical imaging modality that combines superior optical sensitivity and fine ultrasonic resolution in quasi-diffusive regime (~1-3 mm tissues). AR-PAM has been explored for anatomical, functional, molecular information biological tissues. Heretofore, systems have suffered from a limited field-of-view (FOV) and/or slow speed, which precluded them routine preclinical clinical applications. Here, we demonstrate advanced...

Photoacoustic computed tomography (PACT) has become a premier preclinical and clinical imaging modality. Although PACT's image quality can be dramatically improved with large number of ultrasound (US) transducer elements associated multiplexed data acquisition systems, the high system cost and/or slow temporal resolution are significant problems. Here, deep learning-based approach is demonstrated that qualitatively quantitively diminishes limited-view artifacts reduce improves resolution....

Photoacoustic computed tomography (PACT), an emerging imaging modality in preclinical cancer research, can provide multiparametric 3D information about structures, physiological functions, and pharmacokinetics. Here, we demonstrate the use of high-definition PACT both primary metastatic tumors living mice to noninvasively monitor angiogenesis, carcinogenesis, hypoxia, The system with a 1024-element hemispherical ultrasound transducer array provides isotropic spatial resolution 380 μm,...

Recent study has demonstrated that Sasa quelpaertensis (Korean name, Jeju-Joritdae) extracts inhibit cellular melanogenesis implicating potential use in the control of skin pigmentation.The purpose present was to elucidate active constituents this plant inhibiting and associated mechanism.The effect plant-derived materials on melanin production and/or tyrosinase expression examined murine melanoma B16/F10 cells neonatal human melanocytes.When tested treated with alpha-melanocyte stimulating...

Photoacoustic imaging (PAI), recognized as a promising biomedical modality for preclinical and clinical studies, uniquely combines the advantages of optical ultrasound imaging. Despite PAI's great potential to provide valuable biological information, its wide application has been hindered by technical limitations, such hardware restrictions or lack biometric information required image reconstruction. We first analyze limitations PAI categorize them seven key challenges: limited detection,...

The X-ray free-electron laser (XFEL) has remarkably advanced imaging technology and enabled important scientific achievements. XFEL's extremely high power, short pulse width, low emittance, coherence make possible such diverse techniques as absorption/emission spectroscopy, diffraction imaging, scattering imaging. Here, we demonstrate a novel XFEL-based modality that uses the induced acoustic (XA) effect, which call microscopy (XFELAM). Initially, verified XA effect by detecting signals from...

<title>Abstract</title> Large-scale 3D photoacoustic (PA) imaging has become increasingly important for both clinical and pre-clinical applications. Limited by cost system complexity, only systems with sparsely-distributed sensors can be widely implemented, which desires advanced reconstruction algorithms to reduce artifacts. However, high computing memory time consumption of traditional iterative (IR) is practically unacceptable large-scale PA imaging. Here, we propose a point cloud-based...

Abstract Single-element transducer based ultrasound (US) imaging offers a compact and affordable solution for high-frequency preclinical clinical because of its low cost, complexity, high spatial resolution compared to array-based US imaging. To achieve B-mode imaging, conventional approaches adapt mechanical linear or sector scanning methods. However, due speed, cannot acceptable temporal real-time the method requires specialized low-load transducers that are small lightweight. Here, we...

X-ray acoustic imaging is a hybrid biomedical technique that can acoustically monitor absorption distribution in biological tissues through the induced effect. In this study, we developed 3D volumetric X-ray-induced computed tomography (XACT) system with portable pulsed source and an arc-shaped ultrasound array transducer. XACT images are reconstructed via back-projection algorithm, accelerated by custom-developed graphics processing unit (GPU) software. Compared CPU-based software, GPU...

Exogenous contrast agents in photoacoustic imaging help improve spatial resolution and penetration depth enable targeted molecular imaging. To screen efficient signaling materials as agents, we propose a light absorption-weighted figure of merit (FOM) that can be calculated using material data from the literature numerically simulated absorption cross-sections. The FOM shows Ti nanodisc has conversion performance similar to an Au better than Pt nanodisc. results Ti, Au, nanodiscs, which are...

T HE tiltrotor configuration was selected as the unmanned aerial vehicle (UAV) platform for Smart UAV (SUAV) development program, which is one of 21st Frontier research and programs supported by Korean government [1]. Some subsystems SUAV, such rotor system, drive andflight control were especially challenging Korea Aerospace Research Institute to develop, due lack previous experience. To reduce risk failure during development, ironbird test system flight simulation conducted. Although...

Abstract To understand complex biological process and disease progression, it is essential to comprehensively track biodynamics across entire organisms. The invaluable tracking tool, photoacoustic computed tomography (PACT), provides insights into structural, functional, molecular aspects of living tissues. However, current small‐animal PACT systems suffer from low temporal/spatial resolution a restricted field view, they are limited in the information can provide, hindering research on...

Abstract Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By collateral circulation neovascularization after ischemic stroke, natural recovery process can be better understood, optimize further treatment strategies, improve prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality captures multiparametric high‐resolution images vessel structures, well suited for evaluating...

Abstract X-ray induced acoustic imaging (XAI) is an emerging biomedical technique that can visualize absorption contrast at ultrasound resolution with less ionizing radiation exposure than conventional computed tomography. So far, medical linear accelerators or industrial portable tubes have been explored as excitation sources for XAI. Here, we demonstrate the first feasible synchrotron XAI (sXAI). The generates X-rays, a dominant energy of 4 to 30 keV, pulse-width ps, pulse-repetition...

The development of a tilt-duct UAV is presented herein. In order to develop UAV, the power-train characteristics vehicles during helicopter-to-airplane conversion are investigated. full-scale model reflects tethered hover test information and realistic data from scaled down model. prop governor maneuvers handled by proportional–integral controller in both main-prop tail-prop. This provides stable control forces forward backward conversions ducts. path between flight speed tilt angle defined...

Smart TVs provide various forms of entertainment including live TV, games, messaging and web search. Though a smart TV is usually shared by all family members, personalization also necessary. For example, social network service (SNS), e-mail require privacy, channel navigation will be efficient if each user's preference separately managed. This paper presents personalized interface for with multiple users. A platform developed integrating hardware software systems, then an on that designed...

X-ray-induced acoustic computed tomography (XACT) has shown great potential as a hybrid imaging modality for real-time non-invasive x-ray dosimetry and low-dose three-dimensional (3D) imaging. While promising, one drawback of the XACT system is underlying low signal-to-noise ratio (SNR), limiting its in vivo clinical use. In this Letter, we propose first use conventional contrast agent, Gastrografin, improving SNR situ We obtained 3D volumetric images mouse's stomach with orally injected...