A5069679392- RNA Research and Splicing
- RNA modifications and cancer
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
University of British Columbia
2018-2024
British Columbia Children's Hospital
2018
Parkinson disease (PD) is the second most common neurodegenerative disorder and leading cause of motor disability. Pathologic accumulation aggregated alpha synuclein (AS) protein in brain, imbalance nigrostriatal system due to loss dopaminergic neurons substantia nigra- pars compacta, are hallmark features PD. AS aggregation propagation considered trigger neurotoxic mechanisms PD, including mitochondrial deficits oxidative stress. The eukaryotic elongation factor-2 kinase (eEF2K) mediates...
R package pathlinkR is designed to aid transcriptomic analyses by streamlining and simplifying the process of analyzing interpreting differentially expressed genes derived from human RNA-Seq data. It provides an integrated approach performing pathway enrichment network-based analyses, while also producing publication-quality figures summarize these results, allowing users more efficiently interpret their findings extract biological meaning large amounts available install software repository...
Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains need for early biomarkers to facilitate timely intervention. Our objective was identify neonatal gene expression that could predict at birth, prior presentation.