Abstract Extracorporeal Membrane Oxygenation (ECMO) serves as a crucial intervention for patients with severe pulmonary dysfunction by facilitating oxygenation and carbon dioxide removal. While traditional ECMO systems are effective, their large priming volumes significant blood-contacting surface areas can lead to complications, particularly in neonates pediatric patients. Microfluidic offer promising alternative miniaturizing the technology, reducing blood volume requirements, minimizing...

Rotating Detonation Engines (RDE’s) or Combustors (RDC's) are a detonation based combustion method that shows potential capability of high efficiency, compact geometry, and continuous operation. Pressure losses due to friction, flow turning, shock strength could cause loss the efficiency advantages RDEs have over conventional combustion. Some recent numerical studies shown it is possible ignite an RDE has only outer wall, with air going through center instead centerbody. These centerbodiless...

Severity of thoracic aortic disease in Turner syndrome (TS) patients is currently described through measures aorta size and geometry at discrete locations. The objective this study to develop an improved measurement tool that quantifies changes over time, continuously along the length aorta. Cardiovascular magnetic resonance (CMR) scans for 15 TS [41 ± 9 years (mean age standard deviation (SD))] were acquired a 10-year period compared with ten healthy gender age-matched controls....

Microfluidic devices promise to overcome the limitations of conventional hemodialysis and oxygenation technologies by incorporating novel membranes with ultra-high permeability into portable low blood volume. However, characteristically small dimensions these contribute both non-physiologic shear that could damage components laminar flow inhibits transport. While many studies have been performed empirically computationally study hemolysis in medical devices, such as valves pumps, little is...

The pressure gain of detonation has great potential to increase efficiency cycles involving combustion. Rotating engines (RDEs) have a deal promise as based combustor. RDE’s advantages over current pulsed include needing only single initiation, having more uniform exhaust pressure, compact design, and capability process high flow rates. However, without consideration for losses due friction or shock strength, it is possible lose the RDEs conventional Some recent numerical studies shown may...

An experimental investigation was carried out to study the propagation of a shock wave through crossover tube for purpose causing shock-initiated detonation. A pulse detonation engine used as driver source propagate into second, adjacent (that is, driven). Results showed transferred achieved detonation, and specific geometries, there maximum effective length which event possible. This strongly correlated strength shock. Initiation performance in driven declined when incident decreased below...

To address the unmet clinical need for pediatric circulatory support, we are developing an operationally versatile, hybrid, continuous-flow, total artificial heart ("Dragon Heart"). This device integrates a magnetically levitated axial and centrifugal blood pump. Here, utilized validated flow pump, focused on development of A motor was integrated to drive achieving 50% size reduction. The design simulated by finite element analysis, pump improvement attained computational fluid dynamics....

Computational fluid dynamics (CFD) analysis on detonations, and the resulting exhaust are studied. Specifically seeks to quantify relative ability of cycles refill with unburned air that can be mixed fuel for pulsed detonation. The magnitude effects ignition location, basic tube geometry this self-aspiration first investigated in smaller, more time-efficient simulations. From these, additional variables, such as ejectors, different inlet shapes tested most promising configuration overall...

A new air-breathing ethylene-burning Pulse Detonation Engine (PDE) facility has been constructed at the University of Cincinnati (UC). This supports up to six twoinch or three-inch detonation tubes driven by an automotive-derived valving and ignition system Shchelkin-type spirals for deflagration transition (DDT). The PDE is also mated axial-flow power turbine with each tube supplying a one-sixth sector inlet so that efficiency may be studied under partial admission pulsing flow detonating...

Shock wave propagation within a pulse detonation engine–crossover system is investigated, examining the properties and mechanisms of transfer process. A shock transferred through crossover tube that connects spark-ignited driver engine to secondary, driven engine. Detonations in develop from shock-initiated combustion, as strong reflection can cause ignition reactive mixture. decrease deflagration-to-detonation transition length while employing single spark source initiate consisting...

The pressure gain of detonation has great potential to increase efficiency cycles involving combustion. Rotating engines (RDEs) have a deal promise as based combustor. RDE’s advantages over current pulsed include needing only single initiation, having more uniform exhaust pressure, compact design, and capability process high flow rates. With very few exceptions, premixed operation an RDE proven difficult, with the flame igniting supply upstream RDE. As consequence, much energy been put...

A numerical study is performed to characterize the mixing mechanisms and flowfield within a rotating detonation engine system. An axisymmetric baseline domain created as surrogate for Shank 2012 RDE The original design produces poor species in immediate injection zone due low fuel penetration into thick, crossflowing air stream. As stream enters annulus, it turns sharp corner, forming small recirculation region. While peak turbulent diffusion occurs high shear produced by two jets, large...

A University of Cincinnati computational fluid dynamic study is being carried out to investigate obstacles in a Rotating Detonation Engine configuration. two-dimensional periodically bounded simulation used test walls and ramps the path Engine, with respect its ability stabilize flow prevent reversed detonation waves that can cause blowout RDE systems. Data have shown direct initiation near ramp followed by step propagate only direction away from step, if initiated next step. Additional...

A University of Cincinnati experimental study was carried out on a Multi-Pulse Detonation Engine (PDE) crossover system. tubes were connected through varying lengths that allow shockwave to from one PDE another. Only the driving ignited. The current aims investigate effect tube entrance locations operability driven PDE. Results suggest shock initiated detonation is more prevalent when originating in headwall tube, considerable improvement previous results 11,14 . Furthermore, have shown...

The pressure gain of rotating detonation engines has great potential to increase efficiency cycles involving combustion. RDE’s advantages over current pulsed include needing only a single initiation, having more uniform exhaust pressure, compact design, and capability process high flow rates. With very few exceptions, premixed operation an RDE proven difficult, with the flame igniting supply upstream RDE. As consequence, much energy been put toward design mixing system that occurs near or at...

Background: Risks of extracorporeal membrane oxygenation (ECMO) therapy can directly be attributed to large areas and blood circuit volume. These are particularly problematic in neonates with low total volumes. To address this, we developing a miniaturized prototype microfluidic ECMO using versatile 3D printing technologies highly porous membranes. Hemolytic O2 transport assessments geometrical variants the design have been performed vitro silico. Methods: 3D-printed flow paths device...

A University of Cincinnati experimental study was carried out on a Multi-Pulse Detonation Engine (PDE) crossover system. tubes were connected through to allow shockwave transfer from one PDE another. Only the driving ignited. The current aimed investigate effect sustainability an annular array shock initiated detonation in tandem. Various parameters studied optimize array. Results suggest that driver length depends DDT run-length driven PDE. Furthermore, results have shown performance is...

A study has been done on the potential to ignite a detonation by reflected shock in Pulse Detonation Engine (PDE) from another PDE over wider range of crossover tube lengths with dual tubes carrying generated detonation. Frequency firing was also varied test viability at high frequencies and dependence frequency. Two main configurations 2-crossover-tube were tested. One configuration parallel tubes, one downstream other. The other consisted same driver configuration, but modified fitting...

Experiments are carried out as a follow-up to simulation study of potential valveless, self-aspirating, static condition pulse detonation engine designs without pressurized purge. The computational described configuration that after would self-aspirate, evacuating the hot exhaust from (PDE) tube, reducing internal temperature below autoignition fuel and bringing fresh air in. This allows for additional injection shock initiation second cycle. A PDE has been built with geometry was determined...

Background: Risks of extracorporeal membrane oxygenation ECMO therapy can directly be attributed to large area and blood circuit volume. These are particularly problematic in neonates with low To address this, we developing a miniaturized prototype microfluidic using ultrathin highly porous silicone membranes. Hemolytic O2 transport assessment geometrical variants the design have been performed vitro silico. Methods: Flow paths device housings were 3D printed stereolithography (SLA) printer...

A series of experiments are conducted to characterize the effects pulse frequency on performance an axial turbine under pulsating flow. steady flow map is generated over range interest for comparison pulsed results. An investigation partial admission provides additional explanation trends in case. High response probes implemented obtain time-resolved temperature, static pressure, and total pressure across stage. Various formulations efficiency as well other figures merit from these data...