A5056461712- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Lysosomal Storage Disorders Research
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
University of Freiburg
2023-2025
Autophagy is a catabolic process during which cytosolic material enwrapped in newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation lytic compartment of cell. The fusion autophagosomes with tightly regulated step involves membrane-bound SNARE proteins. These play crucial role as they promote lipid mixing opposing membranes. Among proteins implicated autophagy, essential protein YKT6 only that evolutionarily conserved from yeast to humans....
The majority of mitochondrial precursor proteins are imported through the Tom40 β-barrel channel translocase outer membrane (TOM). sorting and assembly machinery (SAM) is essential for protein insertion into thus required TOM complex. Here, we demonstrate that α-helical Mco6 co-assembles with distribution morphology Mdm10 as part SAM machinery. MCO6 MDM10 display a negative genetic interaction, mco6-mdm10 yeast double mutant displays reduced levels Cells lacking affect show defects Thus,...