A5035620467- Trigeminal Neuralgia and Treatments
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Research Studies
- Spinal Cord Injury Research
- Sexual function and dysfunction studies
- Spine and Intervertebral Disc Pathology
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cardiac Health and Mental Health
- Surgical Simulation and Training
- Trauma and Emergency Care Studies
- HIV/AIDS Research and Interventions
- Vascular Malformations Diagnosis and Treatment
- Trauma Management and Diagnosis
- Spinal Dysraphism and Malformations
- Cerebral Venous Sinus Thrombosis
- Intracranial Aneurysms: Treatment and Complications
- Nursing care and research
Johns Hopkins Hospital
2022-2025
Johns Hopkins Medicine
2020-2025
Johns Hopkins University
2020-2025
University of Wyoming
2019-2020
The clinical utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies remains undefined.
Oligodendrogliomas present challenges in management despite their favorable prognosis. Optimal therapeutic strategies are not well-established. We aimed to characterize current practice patterns and identify areas of discordance oligodendroglioma management. A 20-question survey was distributed February-July 2023 four professional neurosurgery/neuro-oncology societies assess practices The collected data on demographics, diagnostic practices, treatment decisions. Data analysis performed using...
BACKGROUNDRapid diagnosis to facilitate urgent intervention is critical for treatment of acute spinal cord injury (SCI). We hypothesized that a multi-analyte blood biomarker would support point-of-care SCI diagnosis, correlate with severity, and predict long-term neurologic outcomes.METHODSDroplet digital PCR (ddPCR) assays were designed amplify differentially hypomethylated genomic loci in tissue. An optimized ddPCR assay was applied cell-free DNA (cfDNA) from plasma samples collected...
INTRODUCTION: Physical examination and neuroimaging are essential components of acute spinal cord injury (SCI) management, yet they have limited spatiotemporal resolution do not capture molecular features SCI. Recent advances in methylation profiling cell-free DNA (cfDNA) allow for detection cell death a tissue specific fashion, raising the possibility developing cord-specific biomarkers. METHODS: We performed methylome human (N=6 subjects via rapid autopsy program) integrated these profiles...
OBJECTIVE Brain metastases (BMs) are the most common CNS tumors, yet their prevalence is difficult to determine. Most studies only report synchronous metastases, which make up a fraction of all BMs. The authors incidence and prognosis patients with metachronous BMs over decade. METHODS Study data were obtained from TriNetX Research Network. Patients included if they had primary cancer diagnosis BM diagnosis, occurring between January 1, 2013, 2023. Metachronous was defined as diagnosed more...
NK cells regulate CD4+ and CD8+ T in acute viral infection, vaccination, the tumor microenvironment. also become exhausted chronic activation settings. The mechanisms causing these ILC responses their impact on adaptive immunity are unclear. cell exhaustion develops during Toxoplasma gondii (T. gondii) infection resulting parasite reactivation death. How T. impacts compartment is not known. We demonstrate that do exhibit hallmarks of exhaustion. Their numbers stable they express high PD1 or...
The extent of resection has been shown to improve outcomes in patients with meningiomas. However, can be complicated by constraining local anatomy, leading subtotal resections. An understanding the natural history residual tumors is necessary better guide postsurgical management and minimize recurrence. This study seeks identify predictors recurrence high growth rate following intracranial
It is often challenging to distinguish cancerous from non-cancerous lesions in the brain using conventional diagnostic approaches. We introduce an analytic technique called Real-CSF (repetitive element aneuploidy sequencing CSF) detect cancers of central nervous system evaluation DNA cerebrospinal fluid (CSF). Short interspersed nuclear elements (SINEs) are PCR amplified with a single primer pair, and products evaluated by next-generation sequencing. assesses genome-wide copy-number...
Brain metastases (BM) constitute a significant cause of oncological mortality. Statistics on the incidence BM are limited because lack systematic nationwide reporting. We report synchronous brain (sBM), defined as identified at time primary cancer diagnosis from 2015 to 2019 using National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End Results Program database.We 1,872,057 patients with malignancies diagnosed between SEER 17 Registries database, including 35,986 (1.9%) sBM....
The extracorporeal telescope (exoscope) presents a novel digital camera system as versatile alternative to traditional optical microscopy for microsurgery and minimally invasive neurosurgical operations. Recent innovations in exoscope technology offer 4K-definition multiscreen outputs, pneumatic robot arms, 3-dimensional depth perception, greater illumination, focus, magnification powers enhanced intraoperative visualization. authors present their initial institutional experience using...
BACKGROUND AND OBJECTIVES: Oligodendrogliomas are defined by IDH1/2 mutation and codeletion of chromosome arms 1p/19q. Although previous studies identified CIC , FUBP1 TERTp as frequently altered in oligodendrogliomas, the clinical relevance these molecular signatures is unclear. Moreover, predominantly used research panels that not readily available to providers patients. Accordingly, we explore genomic alterations molecularly oligodendrogliomas using clinically standardized next-generation...
Whether the total number of compressive vessels in trigeminal neuralgia (TN) affects outcomes after microvascular decompression (MVD) is unknown.To investigate whether associated with MVD.We retrospectively reviewed all patients TN who underwent MVDs at our institution from 2007 to 2020. The and identity on nerve were recorded. Preoperative postoperative pain numbness Barrow Neurological Institute scores compared. Factors recurrence assessed using survival analyses multivariate...
Internal neurolysis (IN) and intraoperative glycerin rhizotomy (ioGR) are emerging surgical options for patients with trigeminal neuralgia without neurovascular contact. The objective of this study was to compare the neurological outcomes who underwent IN those ioGR.
All people with HIV who screen negative for active tuberculosis (TB) should receive isoniazid preventive therapy (IPT). IPT implementation remains substantially below the 90% WHO target. This study sought to further understanding of prescription by piloting a simplified prescribing approach.Primary care clinics in Matlosana, South Africa.This was mixed-methods study.Nine providers were recruited and underwent training on 2018 guidelines. A tool containing antiretroviral (ART) prescriptions...
While the central nervous system (CNS) tumor classification has increasingly incorporated molecular parameters, there is a paucity of literature reporting alterations found in intraventricular glioblastoma (IVGBM), which are rare. We present case series nine IVGBMs, including standardized next-generation sequencing (NGS). queried clinical charts, operative notes, pathology reports, and radiographic images patients with histologically confirmed IVGBM treated at our institution (1995-2021)....
Acute spinal cord injury (SCI) requires prompt diagnosis and intervention to minimize the risk of permanent neurologic deficit. Presently, SCI interventional planning rely on magnetic resonance imaging (MRI), which is not always available or feasible for severely injured patients. Detection disease-specific biomarkers in biofluids via liquid biopsy may provide a more accessible objective means evaluating patients with suspected SCI. Cell-free DNA, has been used diagnosing monitoring...
Placing screws in the high cervical spine can be challenging because of vital anatomical structures located that region. Precision and accuracy with screw placement is needed. The use robotics has been described before; however, here authors describe a new robotic setup.The 2 cases robot-assisted C2 pars C1-2 transarticular screws. operative plans for each patient were as follows: C2-4 fusion hangman's fracture degenerative disease. Intraoperative computed tomography (CT) was used to plan...