A5015306072- Dental materials and restorations
- Oral microbiology and periodontitis research
- Endodontics and Root Canal Treatments
- Antimicrobial agents and applications
- Mesenchymal stem cell research
- Dental Erosion and Treatment
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Silicone and Siloxane Chemistry
- Diatoms and Algae Research
- Orthodontics and Dentofacial Orthopedics
- biodegradable polymer synthesis and properties
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Dental Implant Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Polyoxometalates: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Facial Nerve Paralysis Treatment and Research
- Force Microscopy Techniques and Applications
- Industrial Vision Systems and Defect Detection
- Mesoporous Materials and Catalysis
Tongji Hospital
2014-2025
Huazhong University of Science and Technology
2014-2025
Wuhan University
2018-2024
Hubei Zhongshan Hospital
2021-2024
Infected bone defects are a major challenge in orthopedic treatment. Native tissue possesses an endogenous electroactive interface that induces stem cell differentiation and inhibits bacterial adhesion activity. However, traditional substitutes have difficulty reconstructing the electrical environment of bone. In this study, we develop self-promoted mineralized scaffold (sp-EMS) generates weak currents via spontaneous electrochemical reactions to activate voltage-gated Ca2+ channels, enhance...
Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized by persistently high incidence and mortality rate. The extracellular matrix (ECM) plays crucial role in the initiation, progression, diverse biological behaviors OSCC, facilitated mechanisms such as providing structural support, promoting migration invasion, regulating morphology, modulating signal transduction. This study investigated involvement ECM-related genes, particularly THBS1, prognosis...
Periodontitis is a bacteria-induced inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells (PDLSCs) are capable differentiating into osteoblasts, which an important cell source for endogenous tissue regeneration. Lysine lactylation (Kla) novel post-translational modification proteins that recently thought to be associated with osteogenic differentiation. Here, we found levels reduced both in rats periodontitis and...
Traditional bone regeneration strategies relied on supplementation of biomaterials constructs with stem or progenitor cells growth factors. By contrast, cell homing employ chemokines to mobilize from host marrow and tissue niches injured sites. Although silica-based exhibit osteogenic angiogenic potentials, they lack capability. Stromal cell-derived factor-1 (SDF-1) plays a pivotal role in mobilization tissues. In this work, we demonstrated that 3-dimensional collagen scaffolds infiltrated...
Global increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins removable appliances and retainers. Orthodontic appliance wearers have higher risk oral infections that are caused by formation bacterial fungal biofilms on surface. Here, we present synthetic route an antibacterial antifungal organically-modified silicate (ORMOSIL) has multiple methacryloloxy functionalities attached to siloxane backbone (quaternary ammonium methacryloxy silicate, or...
Abstract Objective This study describes a new approach to regenerate bone defect using autogenous tooth. Materials and methods Freshly extrac‐ted teeth were used as grafts. Teeth sectioned, cut into desired shape, disinfected. The grafts rigidly fixed the mandibular defects in eighteen rabbits titanium screws achieve good stability. Every six stochastically sacrificed at 1, 3, 6 months after implantation, respectively. For all specimens, clinical, radiographical, histological measurements...
Abstract Controlling and reducing the formation of pathogenic biofilm on tooth surface is key to prevention treatment biofilm-associated oral diseases. Antimicrobial peptides (AMPs), considered as possible future alternatives for conventional antibiotics, have been extensively studied control bacterial infection. Due rapid dilution degradation by human saliva, AMP preparations designed use with longer retention higher efficacy are in urgent need. To this end, a hydroxyapatite (HAp)-binding...
Abstract Quaternary ammonium methacryloxy silicate (QAMS)-containing acrylic resin demonstrated contact-killing antimicrobial ability in vitro after three months of water storage. The objective the present double-blind randomised clinical trial was to determine vivo efficacy QAMS-containing orthodontic by using custom-made removable retainers that were worn intraorally 32 human subjects create 48-hour multi-species plaque biofilms, a split-mouth study design. Two control QAMS-free disks...
To evaluate the antibiofilm effect of proanthocyanidin (PA) solution as an irrigant against Enterococcus faecalis (E. faecalis) and its influence on mechanical properties biodegradation resistance demineralized root dentine.Enterococcus were introduced into human dentine tubules by a serial centrifugation method grown for 1 week. Dentine blocks infected with 1-week-old E. biofilms treated following irrigants: sterile water (control), 2% chlorhexidine (CHX), PA, 5% PA 10% PA. After treatment,...
This study aimed to investigate the effect of proanthocyanidin (PA) on osteogenesis mediated by periodontal ligament stem cells (PDLSCs) and endogenous alveolar bone regeneration.Leveraging osteogenic potential resident is a promising strategy for regeneration. PA has been reported be effective in osteogenesis. However, mechanism differentiation PDLSCs remain elusive.Human were treated with various doses assess cell proliferation using Cell Counting Kit-8. The ability was detected qRT-PCR...
With recent developments of molecular biomimetics that combine genetic engineering and nanotechnology, peptides can be genetically engineered to bind specifically inorganic components execute the task collagen matrix proteins. In this study, using biogenous tooth enamel as binding substrate, we identified a new heptapeptide (enamel high-affinity peptide, EHBP) from linear 7-mer peptide phage display library. Through output/input affinity test, it was found EHBP has highest with an ratio...
Autophagy serves an important role in numerous diseases, as well infection and inflammation. Irreversible pulpitis (IP) is one of the most common inflammatory endodontic autophagy has been reported to regulate IP vitro. However, level pathogenic process vivo remains unknown. The aim current study was, thus, investigate levels autophagy‑associated proteins rats with vivo. A rat dental model was successfully constructed, five different time points (0, 1, 3, 5 7 days) were investigated....
Organically modified silicates represent an excellent example of organic–inorganic hybrids in materials science. The routes to achieve incorporation organic functionalities include grafting and co-condensation (one-pot synthesis). Compared with the method, advantage one-pot synthesis manifests as tunability both mechanical biological properties. Herein, we report a silsesquioxane–silica hybrid (SqSH) dual functional groups (alkylammonium methacrylate chains) synthesized by hydrolytic one...
The structural integrity of a dentin matrix that has been demineralized by the clinical use etchants or calcium-depleting endodontic irrigants, such as ethylenediaminetetraacetic acid (EDTA), is often deteriorated due to collagenolytic activities reactivated endogenous enzymes well infiltration extrinsic bacteria. Therefore, biomodification collagen with improved stability and antibacterial activity holds great promise in conservative dentistry. purpose this study was evaluate effects...