A5077872946- Spatial Cognition and Navigation
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Hemispheric Asymmetry in Neuroscience
- Memory and Neural Mechanisms
- Child and Animal Learning Development
- Spatial Neglect and Hemispheric Dysfunction
- Dementia and Cognitive Impairment Research
- Motor Control and Adaptation
- Children's Physical and Motor Development
- Action Observation and Synchronization
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
- Migraine and Headache Studies
- Brain Tumor Detection and Classification
- Vestibular and auditory disorders
- Cognitive Abilities and Testing
- Radiomics and Machine Learning in Medical Imaging
- Cognitive Science and Mapping
- Neural and Behavioral Psychology Studies
Université Toulouse III - Paul Sabatier
2013-2024
Inserm
2013-2024
Université de Toulouse
2013-2024
Fondazione Santa Lucia
2011-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2020
Karolinska Institutet
2014-2019
Imagerie et Cerveau
2018-2019
Imaging Center
2019
Sapienza University of Rome
2011-2014
Centre Hospitalier Universitaire de Toulouse
2013-2014
Background Parkinson's disease (PD) and multiple system atrophy (MSA) are two neurodegenerative alpha-synucleinopathies characterized by severe impairment of the nigro-striatal pathway. Based on T1-, T2*-, diffusion-weighted magnetic resonance imaging (MRI), macro-structural micro-structural abnormalities in these diseases can be detected. Objective This study was undertaken to compare changes that occur patients with PD those both variants MSA (the parkinsonian variant, MSA-P, cerebellar...
Abstract Background: Multimodal MRI approach is based on a combination of parameters sensitive to different tissue characteristics (eg, volume atrophy, iron deposition, and microstructural damage). The main objective the present study was use multimodal identify brain differences that could discriminate between matched groups patients with multiple system Parkinson's disease, healthy controls. We assessed 2 MSA variants, namely, MSA‐P, predominant parkinsonism, MSA‐C, more prominent...
Recently, developmental topographical disorientation (DTD) was described (Bianchini et al ., 2010, J Clin Exp Neuropsychol, 20, 807–27; Iaria & Barton, Brain Res , 206 189–96; Iaria, Bogod, Fox, 2009, Neuropsychologia, 47 30–40) as a navigational deficit in the absence of neurological or psychiatric disorders. Here, we reported case healthy subject who presented this disorder. Dr. WAI 29‐year‐old right‐handed man with normal development and no clinical history diseases affected by very...
Visual mental imagery is a complex process that may be influenced by the content of images. Neuropsychological evidence from patients with hemineglect suggests in domain environments and objects represented separately selectively affected brain lesions. In present study, we used functional magnetic resonance imaging (fMRI) to assess possibility neural segregation among images depicting parts an object, environment (imagined first-person perspective), geographical map, using both mass...
Mathematical performance is highly correlated with several general cognitive abilities, including working memory (WM) capacity. Here we investigated the effect of numerical training using a number-line (NLT), WM (WMT), or combination two on composite score mathematical ability. The aim was to investigate if contributed outcome, and determine baseline neuroimaging predict magnitude improvement. We randomly assigned 308, 6-year-old children WMT, NLT, WMT+NLT control intervention. Overall,...
Florbetapir (AV-45) has been shown to be a reliable tool assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 the ability bind early stages of AD. In this study, we investigated binding and its relation cognitive performance group prodromal stage disease, recruited according strict inclusion criteria. We AD matched control subjects. was assessed using an innovative extraction method allowing quantifying uptake cortex...
AbstractDevelopmental topographical disorientation (DTD) is the presence of navigational deficits in context normal intellectual ability and absence any perinatal, neurological, or psychiatric disorder. As only three cases DTD have been fully described thus far, we are still unable to draw definitive conclusions about its nature relationship with other visuospatial competencies, such as mental rotation. The case Mr. L.A., a 38-year-old man no history neurological disorders, sheds some light...
Abstract There is a long-standing interest in the determinants of successful learning children. “Grit” an individual trait, reflecting ability to pursue long-term goals despite temporary setbacks. Although grit known be predictive future success real-world situations, understanding underlying neural basis and mechanisms still lacking. Here we show that sample 6-year-old children (n = 55) predicts working memory improvement during 8 weeks training on tasks (p .009). In separate neuroimaging...
Developmental topographical disorientation (DTD) causes impaired spatial orientation and navigation from early childhood with no evidence of cerebral damage. Using fMRI a landmark sequencing task, we investigated the hypothesis that Dr Wai's abnormal activation pattern was related to his peculiar behavioral profile. Although Wai able correctly perform sequencing, he showed lack activity in regions activated all control subjects areas were not any subject. These results are discussed light...
One objective of modern neuroimaging is to identify markers that can aid in diagnosis, monitor disease progression, and impact long-term drug analysis. In this study, physiopathological modifications seven subcortical structures patients with mild cognitive impairment (MCI) due Alzheimer's (AD) were characterized by simultaneously measuring quantitative magnetic resonance parameters are sensitive complementary tissue characteristics (e.g., volume atrophy, shape changes, microstructural...
A decline in navigational abilities is a consistent feature of aging. Although many studies focused on recall information, the impact time and type learning has received little attention. We submitted older adults young participants to an extensive training ecological environment, from both route survey perspectives. Then, we tested participants' using benefit training, they did not reach same performance participants. Despite this main effect age, was two groups. Congruence between led...
Introduction: The hippocampus plays a key role in depressive disorder, and the amygdala is involved disorder through that it emotional regulation. Electroconvulsive therapy (ECT) may alter microstructure of these two regions. Since mean diffusivity (MD), known to be an indirect marker microstructural integrity can derived from diffusion tensor imaging (DTI) scans, we aim test hypothesis treatment-resistant depression (TRD) patients undergoing bilateral (BL) ECT exhibit decrease MD their...
Florbetapir (AV-45) has been shown to be a reliable tool for assessing in vivo amyloid load patients with Alzheimer's disease from the early stages. However, nonspecific white matter binding reported healthy subjects as well disease. To avoid this issue, cortical quantification might increase reliability of AV-45 PET analyses. In study, we compared two methods binding, classical method relying on template registration (route 1), and MRI-based 2) quantification.We recruited 22 at prodromal...
Spatial navigation is one of the cognitive functions known to decline in both normal and pathological aging. In present study, we aimed assess neural correlates topographical memory patients with amnestic mild impairment (aMCI). Patients aMCI age-matched controls were engaged an intensive learning paradigm, lasting for 5 days, during which they had encode 1 path from egocentric perspective allocentric perspective. After period, asked retrieve each these paths using or frame reference while...
Recovery from coma might critically depend on the structural and functional integrity of frontoparietal networks. We aimed to measure this in traumatic brain injury anoxo-ischemic (cardiac arrest) patients by using an original multimodal MRI protocol.