A5006527217- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease and Spinal Disorders
- Systemic Lupus Erythematosus Research
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Acute Lymphoblastic Leukemia research
- Nerve injury and regeneration
- Ocular Diseases and Behçet’s Syndrome
- Carcinogens and Genotoxicity Assessment
- COVID-19 and healthcare impacts
- Autism Spectrum Disorder Research
- Hereditary Neurological Disorders
- Fetal and Pediatric Neurological Disorders
Ospedale Vito Fazzi
2021-2024
Magna Graecia University
2013-2020
Université Toulouse III - Paul Sabatier
2015
Université de Toulouse
2015
Inserm
2015
Background Parkinson's disease (PD) and multiple system atrophy (MSA) are two neurodegenerative alpha-synucleinopathies characterized by severe impairment of the nigro-striatal pathway. Based on T1-, T2*-, diffusion-weighted magnetic resonance imaging (MRI), macro-structural micro-structural abnormalities in these diseases can be detected. Objective This study was undertaken to compare changes that occur patients with PD those both variants MSA (the parkinsonian variant, MSA-P, cerebellar...
Abstract Background: Multimodal MRI approach is based on a combination of parameters sensitive to different tissue characteristics (eg, volume atrophy, iron deposition, and microstructural damage). The main objective the present study was use multimodal identify brain differences that could discriminate between matched groups patients with multiple system Parkinson's disease, healthy controls. We assessed 2 MSA variants, namely, MSA‐P, predominant parkinsonism, MSA‐C, more prominent...
Parkinson disease (PD) can be considered as a brain multisystemic arising from dysfunction in several neural networks. The principal aim of this study was to assess whether large-scale structural topological network changes are detectable PD patients who have not been exposed yet dopaminergic therapy (de novo patients). Twenty-one drug-naïve and thirty healthy controls underwent 3T MRI. Next, Diffusion Tensor Imaging (DTI) graph theoretic analyses compute individual white-matter (WM)...
Motor phenotypes of Parkinson's disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown.The main aim study was compare differences in structural connectivity metrics motor network between tremor-dominant nontremor PD (TD-PD NT-PD, respectively) using probabilistic tractography-based analysis.A total 63 patients (35 TD-PD 28 NT-PD patients) 30 healthy controls underwent a 3 T MRI.Next,...
Background/Objectives: Osteoporosis is a skeletal disorder characterized by reduced bone mineral density (BMD) and increased fracture risk. Chronic inflammation implicated in osteoporosis pathogenesis, with inflammatory mediators promoting resorption. The neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) are markers of systemic have emerged as potential indicators health. This study’s aim was to highlight the role NLR PLR health postmenopausal women affected or osteopenia...
ABSTRACT Background Idiopathic normal pressure hydrocephalus and PSP share several clinical radiological features, making differential diagnosis, at times, challenging. Objectives To differentiate idiopathic from using MR volumetric linear measurements. Methods Twenty‐seven patients, 103 probable 43 control subjects were consecutively enrolled. Automated ventricular volumetry was performed Freesurfer 6 on T 1 ‐weighted images. Linear measurements, such as callosal angle a new measure, termed...
ABSTRACT Imaging measurements, such as the ratio of midsagittal areas midbrain and pons (midbrain/pons) Magnetic Resonance Parkinsonism Index (MRPI), have been proposed to differentiate progressive supranuclear palsy (PSP) from Parkinson's disease (PD). However, abnormal midbrain/pons values suggestive PSP also reported in elderly individuals patients with PD. We investigated effect aging on single or combined imaging measurements brainstem. calculated MRPI (the multiplied by middle...
To explore the usefulness of histogram analysis mean diffusivity (MD) derived from diffusion-weighted imaging large infratentorial structures to distinguish parkinsonian syndromes.Local research ethics committee approval and informed consent were obtained. Ten patients with Parkinson disease (PD), nine variant multiple system atrophy (MSA-P), seven cerebellar MSA (MSA-C), 17 progressive supranuclear palsy-Richardson syndrome (PSP-RS), 10 healthy subjects recruited. Histograms MD values...
Dopamine transporter (DaT) imaging (DaTSCAN) is useful for the differential diagnosis of parkinsonian syndromes. Visual evaluation DaTSCAN images represents generally accepted diagnostic method, but it strongly dependent on observer's experience and shows inter- intra-observer variability. A reliable automatic method can provide objective quantification; desirable longitudinal studies, allows a better follow-up control. Moreover, crucial an automated to produce coherent measures related...
ABSTRACT Background No prospective study of patients with Parkinson's disease (PD) has investigated the appearance vertical gaze abnormalities, a feature suggestive progressive supranuclear palsy (PSP). Objective To identify, within cohort an initial diagnosis PD, those who developed abnormalities during 4‐year follow‐up, and to investigate performance new imaging biomarkers in predicting abnormalities. Methods A total 110 initially classified as PD 74 controls were enrolled. All underwent...
The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in a selected population with Alzheimer disease (AD). We evaluated 87 subjects (37 males 50 females, mean age 70 (±6) years old) AD. All them were subjected TSH, fT3 fT4 assay cerebrospinal fluid amyloid...
Several neuroimaging studies have been carried out to gain insight on the pathological processes that cause PD, but literature findings are inconsistent. The aim of this study was combine information by functional imaging with DA transporter ligands and structural MRI.Forty-two untreated, de novo-PD patients 30 control subjects were involved in study. Patients divided subgroups according presence uni- or bilateral reduction ligand uptake putamen, as observed single-photon emission...