A5060036331- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Glycogen Storage Diseases and Myoclonus
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- Cardiac electrophysiology and arrhythmias
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Lysosomal Storage Disorders Research
- Tryptophan and brain disorders
- Carbohydrate Chemistry and Synthesis
- RNA regulation and disease
- Neurological and metabolic disorders
- Sleep and Wakefulness Research
- Medical Imaging and Pathology Studies
- Restless Legs Syndrome Research
- Autism Spectrum Disorder Research
Magna Graecia University
2007-2024
National Research Council
2013-2023
Institute of Molecular Bioimaging and Physiology
2014-2023
Universidad Complutense de Madrid
2021-2022
Research Institute Hospital 12 de Octubre
2022
Centro de Investigación Biomédica en Red de Salud Mental
2021-2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022
National Academies of Sciences, Engineering, and Medicine
2010-2016
Nuovo Ospedale San Giovanni di Dio
2016
Monash University
2016
Our aim was to investigate the presence of brain gray matter (GM) abnormalities in patients with different forms essential tremor (ET).We used optimized voxel-based morphometry (VBM) and manually traced single region-of-interest analysis 50 familial ET 32 healthy subjects. Thirty had arms (a-ET), whereas remaining 20 both arm head (h-ET).VBM showed marked atrophy cerebellar vermis h-ET respect subjects (P(corrected) < .001). Patients a-ET a trend toward vermal GM volume loss that did not...
The aim of our study was to investigate the microstructural integrity brain regions functionally involved in tremor loop patients with familial essential (FET), using diffusion tensor imaging (DTI).Twenty-five FET, 15 Parkinson disease (PD), and healthy subjects were studied. DTI performed measure fractional anisotropy (FA) mean diffusivity (MD) various interest: red nucleus, dentate nucleus (DN), cerebellar white matter, middle (MCP) superior peduncle (SCP), ventrolateral thalamus.In FA...
Objective: It is well known that the hippocampus presents significant asymmetry in Alzheimer's disease (AD) and difference volumes between left right exists varies with progression. However, few works investigated whether degree of subfields changes through continuum from Mild Cognitive Impairment (MCI) to AD. Thus, aim present work was evaluate Asymmetry Index (AI) hippocampal substructures as possible MRI biomarkers Dementia. Moreover, we aimed assess presented peculiar differences...
Essential tremor (ET) is a slowly progressive disorder characterized by postural and kinetic tremors most commonly affecting the forearms hands. Several lines of evidence from physiologic neuroimaging studies point toward major role cerebellum in this disease. Recently, voxel-based morphometry (VBM) has been proposed to quantify cerebellar atrophy ET. However, VBM was not originally designed study subcortical structures, complicated anatomy may hamper automatic processing VBM. The aim...
Essential tremor is a common neurological disorder characterized by motor and cognitive symptoms including working memory deficits. Epidemiological research has shown that patients with essential are at higher risk to develop dementia relative age-matched individuals; this demonstrates impairments reflect specific, although poorly understood, disease mechanisms. Neurodegeneration of the cerebellum been implicated in pathophysiology itself; however, whether cerebellar dysfunctions relate...
The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant multiple system atrophy (MSA-P). Conventional MRI can help in differentiating disorders but its diagnostic accuracy is still unsatisfactory. On basis pathological demonstration superior cerebellar peduncle (SCP) patients PSP, we assessed SCP apparent diffusion coefficient (ADC)...
Combined measurements on conventional magnetic resonance imaging (MRI), such as midbrain area/pons area or parkinsonism index (MRPI) (pons area/midbrain × middle cerebellar peduncle width/superior width), have been proposed powerful tools in the differential diagnosis between progressive supranuclear palsy (PSP) and Parkinson disease (PD). In this study, we evaluated accuracy of MRPI, compared with midbrain/pons ratio, distinguishing PSP from probable possible PD.Forty-two patients, 170 PD...
Parkinson disease (PD) can be considered as a brain multisystemic arising from dysfunction in several neural networks. The principal aim of this study was to assess whether large-scale structural topological network changes are detectable PD patients who have not been exposed yet dopaminergic therapy (de novo patients). Twenty-one drug-naïve and thirty healthy controls underwent 3T MRI. Next, Diffusion Tensor Imaging (DTI) graph theoretic analyses compute individual white-matter (WM)...
Levodopa-induced dyskinesias represent disabling complications from long-term therapy with dopaminergic drugs for treating Parkinson's disease (PD). Although several neuroimaging studies have reported altered striatofrontal function that contributes to the emergence of these motor complications, neuroanatomical correlates this disorder are still unknown. Optimized voxel-based morphometry (VBM) was applied MRI brain images 36 PD patients levodopa-induced dyskinesias, without and 32 age-...
Abstract Recent studies have reported an association between the glucocerebrosidase ( GBA ) gene and Parkinson's disease (PD). To elucidate role of this in our population, we screened 395 PD patients 483 controls from southern Italy for N370S L444P mutations. We found 11 (2.8%) carrying a heterozygous mutant allele, whereas only one control subject (0.2%) had substitution P = 0.0018). These results strongly suggest that Italian carriers mutation increased risk developing PD. © 2007 Movement...
<h3>Objective:</h3> Magnetic resonance parkinsonism index (MRPI) has been proposed as a powerful tool to discriminate patients with progressive supranuclear palsy (PSP) from those Parkinson disease (PD) or other parkinsonisms, on an individual basis. We investigated the usefulness of MRPI in predicting clinical evolution PSP clinically unclassifiable (CUP), i.e., not fulfilling established diagnostic criteria for any parkinsonian disorders, using cohort study. <h3>Methods:</h3> Forty-five...
Abstract Levodopa‐induced dyskinesia represents disabling complication of long‐term therapy with dopaminergic drugs in treating Parkinson's disease (PD). Recently, our group demonstrated that PD patients levodopa‐induced were characterized by abnormal volumetric changes the inferior prefrontal gyrus. In this study, functional relevance structural abnormality was explored using magnetic resonance imaging. Ten dyskinetic and 10 nondyskinetic studied OFF phase imaging while performing...
Motor phenotypes of Parkinson's disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown.The main aim study was compare differences in structural connectivity metrics motor network between tremor-dominant nontremor PD (TD-PD NT-PD, respectively) using probabilistic tractography-based analysis.A total 63 patients (35 TD-PD 28 NT-PD patients) 30 healthy controls underwent a 3 T MRI.Next,...
To identify a biomarker for predicting the appearance of vertical supranuclear gaze palsy (VSGP) in patients affected by progressive palsy-parkinsonism (PSP-P).Twenty-four with PSP-P were enrolled current study. Patients clinically followed up every 6 months until VSGP or end follow-up (4 years). Participants underwent MRI at baseline and follow-up. Magnetic resonance parkinsonism index (MRPI), an imaging measure useful diagnosing PSP, was calculated.Twenty-one completed follow-up, 3 dropped...
Abstract The cooccurrence of rest and postural tremor (mixed tremor) as the predominant clinical manifestation in patients who do not fulfill diagnostic established criteria for essential (ET) or Parkinson's disease (PD) poses a challenge. Twenty‐two with mixed additional mild extrapyramidal features, such bradykinesia rigidity, 20 probable PD, 10 ET, 18 controls were investigated through combined use dopamine transporter 123 I‐FP‐CIT‐single‐photon emission tomography (DAT‐SPECT) cardiac...