A5091782550- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Cerebrospinal fluid and hydrocephalus
- Glycogen Storage Diseases and Myoclonus
- Neurological and metabolic disorders
- EEG and Brain-Computer Interfaces
- Restless Legs Syndrome Research
- Cellular Automata and Applications
- Neuroscience and Neural Engineering
- Obstructive Sleep Apnea Research
- Migraine and Headache Studies
- RNA regulation and disease
- Fetal and Pediatric Neurological Disorders
- Sleep and Wakefulness Research
- MicroRNA in disease regulation
- Transcranial Magnetic Stimulation Studies
- Neuroscience of respiration and sleep
- Bioinformatics and Genomic Networks
- Ophthalmology and Eye Disorders
- Advanced X-ray and CT Imaging
- Spinal Dysraphism and Malformations
Institute of Molecular Bioimaging and Physiology
2013-2024
National Research Council
2014-2024
Magna Graecia University
2010-2024
National Academies of Sciences, Engineering, and Medicine
2016
Ospedale Annunziata di Cosenza
2016
Nuovo Ospedale San Giovanni di Dio
2016
Monash University
2016
Heart rate variability (HRV) is commonly used to assess autonomic functions and responses environmental stimuli. It usually derived from electrocardiographic signals; however, in the last few years, photoplethysmography has been successfully evaluate beat-to-beat time intervals changes human heart under several conditions. The present work describes a simple design of photoplethysmograph, using wearable earlobe sensor. Beat-to-beat were evaluated as between subsequent pulses, thus generating...
Differentiating progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) is clinically challenging.This study aimed to develop an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm distinguish PSP-P PD and validate its diagnostic performance in two large independent cohorts.We enrolled 676 participants: a training cohort (n = 346; 43 PSP-P, 194 PD, 109 control subjects) our center testing 330; 62 171 97 international research group. We developed...
To identify a biomarker for predicting the appearance of vertical supranuclear gaze palsy (VSGP) in patients affected by progressive palsy-parkinsonism (PSP-P).Twenty-four with PSP-P were enrolled current study. Patients clinically followed up every 6 months until VSGP or end follow-up (4 years). Participants underwent MRI at baseline and follow-up. Magnetic resonance parkinsonism index (MRPI), an imaging measure useful diagnosing PSP, was calculated.Twenty-one completed follow-up, 3 dropped...
Introduction Differential diagnosis of rest tremor (RT) disorders is challenging, often requiring 123I-ioflupane single-photon-emission-computed tomography (DaTscan), an expensive technique not available worldwide. In the current study, we investigated performance a new wearable mobile device termed “RT-ring” in predicting DaTscan result patients presenting with RT based on inertial features. Methods Consecutive underwent RT-ring analysis, surface electromyography (sEMG), and DaTscan. The...
ABSTRACT Background Idiopathic normal pressure hydrocephalus and PSP share several clinical radiological features, making differential diagnosis, at times, challenging. Objectives To differentiate idiopathic from using MR volumetric linear measurements. Methods Twenty‐seven patients, 103 probable 43 control subjects were consecutively enrolled. Automated ventricular volumetry was performed Freesurfer 6 on T 1 ‐weighted images. Linear measurements, such as callosal angle a new measure, termed...
ABSTRACT Background Enlargement of the third ventricle has been reported in atypical parkinsonism. We investigated whether measurement width could distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP). Methods assessed a new MR T1‐weighted (third width/internal skull diameter) training cohort 268 participants (98 PD, 73 PSP, 98 controls our center) and testing 291 (82 de novo PD patients 133 Progression Markers Initiative, 76 early‐stage PSP an international research...
Involuntary tremor at rest is observed in patients with Parkinson’s disease (PD) or essential (ET). Electromyography (EMG) studies have shown that phase displacement between antagonistic muscles prevalent frequency can accurately differentiate resting PD from detected ET. Currently, evaluation qualitative most cases. The aim of this study to develop and validate a new mobile tool for the automated quantitative characterization (resting pattern) ambulatory clinical settings. A low-cost,...
ABSTRACT Imaging measurements, such as the ratio of midsagittal areas midbrain and pons (midbrain/pons) Magnetic Resonance Parkinsonism Index (MRPI), have been proposed to differentiate progressive supranuclear palsy (PSP) from Parkinson's disease (PD). However, abnormal midbrain/pons values suggestive PSP also reported in elderly individuals patients with PD. We investigated effect aging on single or combined imaging measurements brainstem. calculated MRPI (the multiplied by middle...
ABSTRACT Background No prospective study of patients with Parkinson's disease (PD) has investigated the appearance vertical gaze abnormalities, a feature suggestive progressive supranuclear palsy (PSP). Objective To identify, within cohort an initial diagnosis PD, those who developed abnormalities during 4‐year follow‐up, and to investigate performance new imaging biomarkers in predicting abnormalities. Methods A total 110 initially classified as PD 74 controls were enrolled. All underwent...
Differentiating Progressive supranuclear palsy-Richardson's syndrome (PSP-RS) from PSP-Parkinsonism (PSP-P) may be extremely challenging. In this study, we aimed to distinguish these two PSP phenotypes using MRI structural data.Sixty-two PSP-RS, 40 PSP-P patients and 33 control subjects were enrolled. All underwent brain 3 T-MRI; cortical thickness cortical/subcortical volumes extracted Freesurfer on T1-weighted images. We calculated the automated MR Parkinsonism Index (MRPI) its second...
Most patients with idiopathic REM sleep behavior disorder (iRBD) present peculiar repetitive leg jerks during in their clinical spectrum, called periodic movements (PLMS). The differentiation of iRBD and without PLMS is challenging, polysomnographic confirmation. aim this study to develop a new Machine Learning (ML) approach distinguish between phenotypes. Heart rate variability (HRV) data were acquired from forty-two consecutive (23 19 PLMS). All participants underwent video-polysomnography...
The objective of this article is to determine whether cutaneous allodynia (CA) influences the response treatment with occipital transcutaneous electrical stimulation (OTES) in chronic migraine (CM) and tension-type headache (CTTH).One hundred sixty consecutive patients CM or CTTH were randomized be treated real sham OTES three times a day for two weeks. All completed validated 12-item symptom checklist assessing presence severity CA during attack. Primary end-point was change (≥50%) number...
Rest tremor (RT) is observed in subjects with Parkinson's disease (PD) and Essential Tremor (ET). Electromyography (EMG) studies have shown that PD exhibit alternating contractions of antagonistic muscles involved tremors, while the contraction pattern synchronous ET subjects. Therefore, RT can be used as a potential biomarker for differentiating from In this study, we developed new wearable device method using inertial data. The novelty our approach relies on fact evaluation or patterns...