A5015745631- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Genetic Neurodegenerative Diseases
- COVID-19 and Mental Health
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Stroke Rehabilitation and Recovery
- Cognitive Functions and Memory
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Long-Term Effects of COVID-19
- Ginkgo biloba and Cashew Applications
- Brain Tumor Detection and Classification
- Neural dynamics and brain function
- Neurobiology of Language and Bilingualism
- COVID-19 Pandemic Impacts
- Traumatic Brain Injury Research
- GDF15 and Related Biomarkers
- Neurological diseases and metabolism
University of Padua
2015-2025
IRCCS San Camillo Hospital
2016-2020
Ospedale generale di zona San Camillo Treviso
2015-2018
Abstract Dynamic functional connectivity captures temporal variations of during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson’s disease. In this study, we evaluated 118 patients with disease matched for age, sex education 35 healthy control subjects. Patients were classified normal cognition (n = 52), mild impairment 46), dementia 20) based on an extensive neuropsychological evaluation. Resting state sliding-window approach used study the dynamic...
The COVID-19 pandemic and government imposed social restrictions like lockdown exposed most individuals to an unprecedented stress, increasing mental health disorders worldwide. We explored subjective cognitive functioning changes their possible interplay related COVID-19-lockdown. also investigated potential risk factors identify more vulnerable groups. Across Italy, 1215 respondents completed our Qualtrics-based online-survey during the end of a seven 10-week home confinement (from April...
ABSTRACT Background Asymmetric hemispheric loss of dopaminergic neurons is one the characteristic features Parkinson's disease (PD). However, it still debated if right or left asymmetry differently affects cognitive and motor progression. Objectives The objective this study was to investigate, for first time, relevance dopamine transporter (DAT) on manifestations at onset 4‐year progression in drug‐naïve PD. Methods From Progression Markers Initiative multicenter cohort, we identified 249...
Differentiating progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) is clinically challenging.This study aimed to develop an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm distinguish PSP-P PD and validate its diagnostic performance in two large independent cohorts.We enrolled 676 participants: a training cohort (n = 346; 43 PSP-P, 194 PD, 109 control subjects) our center testing 330; 62 171 97 international research group. We developed...
Abstract Background The Magnetic Resonance Parkinsonism Index is listed as one of the most reliable imaging morphometric markers for diagnosis progressive supranuclear palsy (PSP). However, use this index in diagnostic workup has been limited until now by low generalizability published results because small monocentric patient cohorts, lack data validation independent series, and manual measurements used calculation. objectives study were to investigate performance validating previously...
Abstract Background Higuchi's fractal dimension (FD) captures brain dynamics complexity and may be a promising method to analyze resting‐state functional magnetic resonance imaging (fMRI) data detect the neuronal interaction underlying Parkinson's disease (PD) cognitive decline. Objectives The aim was compare FD with more established index of spontaneous neural activity, fractional amplitude low‐frequency fluctuations (fALFF), identify through machine learning (ML) models which could best...
Abstract The International Parkinson’s and Movement Disorder Society (MDS) criteria for progressive supranuclear palsy (PSP) have broadened the clinical spectrum of disease established phenotypic characterization according to predominant manifestation at onset. objective this study is describe clinical/cognitive imaging features a monocentric cohort PSP patients, highlighting different patterns functional disability assigned phenotype. We retrospectively reviewed clinical/imaging data 53...
Early detection of Parkinson's Disease (PD) progression remains a challenge. As remote patient monitoring solutions (RMS) and artificial intelligence (AI) technologies emerge as potential aids for PD management, there's gap in understanding how end users view these technologies. This research explores neurologist perspectives on AI-assisted RMS.
Background Remote monitoring solutions (RMS) have the potential to improve Parkinson's disease (PD) management by enabling continuous symptom tracking and personalized care. Understanding patient preferences for RMS features is essential successful implementation. Objective This study aimed investigate of people with (PwP) identify preference heterogeneity across distinct subgroups. Methods From November 2023 February 2024, a discrete choice experiment (DCE) was conducted among PwP in...
Both errorless learning (EL) and Goal Management Training (GMT) have been shown effective cognitive rehabilitation methods aimed at optimizing the performance on everyday skills after brain injury. We examine whether a combination of EL GMT is superior to traditional for training complex daily tasks in brain-injured patients with executive dysfunction. This was an assessor-blinded randomized controlled trial conducted 67 impairments due injury non-progressive nature (minimal post-onset time:...
The pathological processes underlying cognitive impairment in Parkinson's disease (PD) are heterogeneous and the contribution of cerebral amyloid deposits is poorly defined, particularly early stages disease. To investigate regional [18F]florbetaben binding to amyloid-β (Aβ) its dysfunction stage PD. A multicenter cohort 48 PD patients from Progression Marker Initiative (PPMI) underwent positron emission tomography (PET) scanning. Clinical features, including demographic characteristics,...
ABSTRACT Background Enlargement of the third ventricle has been reported in atypical parkinsonism. We investigated whether measurement width could distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP). Methods assessed a new MR T1‐weighted (third width/internal skull diameter) training cohort 268 participants (98 PD, 73 PSP, 98 controls our center) and testing 291 (82 de novo PD patients 133 Progression Markers Initiative, 76 early‐stage PSP an international research...
Abstract Dementia in Lewy Body Diseases (Parkinson’s disease and dementia with Bodies) affects progression of disabilities, quality life well-being. Understanding its pathogenetic mechanisms is critical to properly implement disease-modifying strategies. It has been hypothesized that synuclein- amyloid-pathology act synergistically aggravating cognitive decline elderly patients but their precise contribution debated. In this study, we aimed at exploring if presence amyloid deposits...
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson's disease (PD) lies the notable decrease functioning due to impairment. The Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed assess functional limitations caused by impairment, while reducing influence of motor aim this multicenter study (i) validate Italian version PD-CFRS PD, (ii) determine optimal cut-off scores for detecting MCI (iii) compare its performances with most...