A5102776629- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Bacterial Genetics and Biotechnology
- Cancer-related Molecular Pathways
- Bacteriophages and microbial interactions
- DNA and Nucleic Acid Chemistry
- Amino Acid Enzymes and Metabolism
- RNA Research and Splicing
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Cancer Treatment and Pharmacology
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Microbial Natural Products and Biosynthesis
- Synthesis and Reactions of Organic Compounds
- Trypanosoma species research and implications
- Synthesis and Characterization of Pyrroles
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Asymmetric Synthesis and Catalysis
- Antimicrobial Peptides and Activities
Ohio University
2010-2024
Wayne State University
2022
Henry Ford Health System
2022
Legacy Health
2022
Biotechnology Institute
2012
University of Montana
2001
University of Michigan
1991-2000
The Ohio State University
1999
Lawrence Berkeley National Laboratory
1996
University of California, Berkeley
1993-1995
The functional and therapeutic importance of the Warburg effect is increasingly recognized, glycolysis has become a target anticancer strategies. We recently reported identification group novel small compounds that inhibit basal glucose transport reduce cancer cell growth by deprivation-like mechanism. hypothesized Glut1 are efficacious in vivo as agents. Here, we report representative compound WZB117 not only inhibited lines but also nude mouse model. Daily intraperitoneal injection at 10...
Abstract Background Cancer cells drastically increase the uptake of glucose and metabolism by overexpressing class I transporters (GLUT1-4) to meet their energy biomass synthesis needs are very sensitive vulnerable deprivation. Although targeting via GLUTs has been an attractive anticancer strategy, relative efficacy multi-GLUT or single GLUT is unclear. Here, we report DRB18, a synthetic small molecule, potent compound whose pan-class inhibition superior targeting. Methods Glucose...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-amino-.alpha.-hydroxy acids via aldol condensation a chiral glycolate enolate. A synthesis (-)-bestatinWilliam H. Pearson and Jennifer V. HinesCite this: J. Org. Chem. 1989, 54, 17, 4235–4237Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00278a050https://doi.org/10.1021/jo00278a050research-articleACS PublicationsRequest reuse...
The enantiomers and the cis isomers of two previously studied 4,5-disubstituted oxazolidinones have been synthesized, their binding to T-box riboswitch antiterminator model RNA has investigated in detail. Characterization ligand affinities site localization indicates that there is little stereospecific discrimination for alone. This similarity between likely due surface binding, which accommodates conformations result comparable ligand-antiterminator contacts. These results significant...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-Proton Scalar Couplings in RNA: 3D Heteronuclear and 2D Isotope-Edited NMR of a 13C-Labeled Extra-stable HairpinJennifer V. Hines, Stacy M. Landry, Gabriele Varani, Ignacio Tinoco Jr.Cite this: J. Am. Chem. Soc. 1994, 116, 13, 5823–5831Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June...
The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the binding a series 4,5-disubstituted 2-oxazolidinones bind to highly conserved bulge region bacterial RNA. This biological T box antitermination system, which found mainly Gram-positive bacteria, regulates expression several amino acid related genes. In an effort amplify our library, we have prepared library 1,4-disubstituted 1,2,3-triazole analogs...
Three approaches were examined for the synthesis of 3-(hydroxymethyl)pyrrolizidines, a class compounds that includes polyhydroxylated pyrrolizidine alkaloids alexine (1), australine (2), and various stereoisomers thereof. In first approach, intramolecular cycloaddition an azide onto electron-rich 1,3-diene bearing terminal alkoxymethyl substituent (i.e., 21) afforded dehydropyrrolizidines 22a 22b, with predominating. A rationale this stereoselectivity was proposed. Transformation major...
The intramolecular dipolar cycloaddition of an azide with alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the ring and oxazolidin-2-one system. requisite azido-alkynes have been prepared via two-step sequence from aziridines. A series 6–12 membered rings oxazolidinone prepared. These systems designed as conformationally restrained analogs RNA-binding oxazolidinones.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe stereospecific assignment of H5' and H5'' in RNA using the sign two-bond carbon-proton scalar couplingsJennifer V. Hines, Gabriele Varani, Stacy M. Landry, Ignacio Tinoco Jr.Cite this: J. Am. Chem. Soc. 1993, 115, 23, 11002–11003Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00076a073https://doi.org/10.1021/ja00076a073research-articleACS...
RNA thermometers are cis-acting riboregulators that mediate the posttranscriptional regulation of gene expression in response to environmental temperature. Such is conferred by temperature-responsive structural changes within thermometer directly result differential ribosomal binding regulated transcript. The significance controlling bacterial physiology and pathogenesis becoming increasingly clear. This study combines silico, molecular genetics, biochemical analyses characterize both...
The T box riboswitch controls bacterial transcription by structurally responding to tRNA aminoacylation charging ratios. Knowledge of the thermodynamic stability difference between two competing structural elements within riboswitch, terminator and antiterminator, is critical for effective box-targeted drug discovery. ΔG aminoacyl synthetase (aaRS) terminators antiterminators was predicted using DINAMelt resulting ΔΔG (ΔGTerminator - ΔGAntiterminator) values were compared. Average did not...