A5003380664- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Amino Acid Enzymes and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Skin Protection and Aging
- Heat shock proteins research
- Osteoarthritis Treatment and Mechanisms
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Antioxidant Activity and Oxidative Stress
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Physiological and biochemical adaptations
- Nitric Oxide and Endothelin Effects
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- RNA modifications and cancer
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Bioactive Compounds and Antitumor Agents
- melanin and skin pigmentation
- Free Radicals and Antioxidants
Nationwide Children's Hospital
2023-2025
Biotechnology Institute
2013-2023
Ohio University
2013-2023
Tsinghua University
2015-2018
The functional and therapeutic importance of the Warburg effect is increasingly recognized, glycolysis has become a target anticancer strategies. We recently reported identification group novel small compounds that inhibit basal glucose transport reduce cancer cell growth by deprivation-like mechanism. hypothesized Glut1 are efficacious in vivo as agents. Here, we report representative compound WZB117 not only inhibited lines but also nude mouse model. Daily intraperitoneal injection at 10...
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) affecting more than 2.5 million patients worldwide. Chronic demyelination in CNS has important role perpetuating axonal loss increases difficulty promoting remyelination. Therefore, regenerative, neuroprotective strategies are essential to overcome this impediment rescue integrity function. Neurotrophin 3 (NT-3) immunomodulatory anti-inflammatory properties,...
Sarcopenia is progressive loss of muscle mass and strength, occurring during normal aging with significant consequences on the quality life for elderly. Neurotrophin 3 (NT-3) an important autocrine factor supporting Schwann cell survival differentiation stimulating axon regeneration myelination. NT-3 involved in maintenance neuromuscular junction (NMJ) integrity, restoration impaired radial growth fibers through activation Akt/mTOR pathway. We tested efficacy gene transfer therapy wild type...
Abstract Carnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, anti-cancer properties. In this report, we evaluated the therapeutic potential elucidated mechanism of action carnosol in chemoprevention ultraviolet B-light (UVB) induced non-melanoma skin cancer formation. Our data indicated that could partially reduce UVB-induced reactive oxygen species (ROS) elevation thus DNA damage. It also formation cyclobutane...
NF-κB is a transcription factor involved in many signaling pathways that also plays an important role UV-induced skin tumorigenesis. UV radiation can activate NF-κB, but the detailed mechanism remains unclear. In this study, we provided evidence activation of constitutive nitric-oxide synthase regulation IκB reduction and human keratinocyte HaCaT cells early phase (within 6 h) post-UVB. Treating with l-NAME, selective inhibitor (cNOS), partially reverse inhibit DNA binding activity as well...
Cartilage damage and wear can lead to severe diseases, such as osteoarthritis, thus, many studies on the cartilage process have already been performed better understand mechanism. However, most characterization methods focus surface or total extent. With advantages of high spatial resolution easy characterization, Raman microspectroscopy was employed for first time characterize full-depth changes in extracellular matrix (ECM) after test. Sections from samples were compared with sections...
Human homolog double minute 2 (hdm2), an oncoprotein, which binds to tumor suppressor p53 facilitate its degradation, has been known contribute tumorigenesis. Its splicing variants are reported be highly expressed in many cancers and can induced by ultraviolet B light (UVB). However, the mechanisms of how UVB radiation induces hdm2 alternative still remain unclear. In this study, we investigated roles two common factors, heterogeneous nuclear ribonucleoproteins (hnRNP) A1...
Abstract Cold‐inducible RNA binding protein ( CIRP ) is a stress‐inducible protein, which could be activated by various cellular stresses, such as hypothermia, hypoxia and UV irradiation. Our previous study indicated that UVB radiation (3 mJ cm −2 induces expression, promotes keratinocytes growth, survival eventually transformation via activation of STAT 3‐Bag‐1/S signaling cascade. However, the mechanism(s) in regulating p‐ 3 Bag‐1/S expression have not been fully elucidated. In this study,...
Alternative splicing plays an important role in proteasome diversity and gene expression regulation eukaryotic cells. Hdm2, the human homolog of mdm2 (murine double minute oncogene 2), is known to be as its suppression p53. Hdm2 alternative splicing, occurs both tumor normal tissues, believed a response cells for cellular stress, thus modulate p53 activity. Therefore, understanding hdm2 critical elucidating mechanisms development progression. In this study, we determined effect ultraviolet B...
BACKGROUND: Knee osteoarthritis (OA) is suggested to be induced by multi-factors, and mechanical environment regarded as a risky factor.OBJECTIVE: To investigate the effect of isolated factor on cartilage.METHODS: An active wear test system was designed perform parameters-controlled in vitro tests rat knee joints with specific load magnitude, flexion-extension angle, movement frequency.Six hind limbs 9-month-old male Sprague-Dawley rats, an additional spring medial side, were worn using...
Cold inducible RNA binding protein (CIRP), also named A18 hnRNP or CIRBP, is a cold-shock RNA-binding which can be induced upon various cellular stresses. Its expression level in cancer tissues relative to adjacent normal tissues; this believed play critical role development and progression. In study, we investigated the of CIRP cells exposed ionizing radiation. Our data show that reduction causes cell colony formation viability after irradiation. addition, knockdown demonstrated higher DNA...
Abstract Increased dependence on glycolysis and glucose metabolism, known as the Warburg effect, is a near-universal hallmark of cancer. The functional therapeutic importance effect has been increasingly recognized become new target anticancer strategies. We recently reported identification group novel small compounds that inhibit basal transport reduce cancer cell growth by using deprivation-like mechanism. Based these other results, we hypothesized targeting Glut1 they are efficacious in...
Abstract Cancer cells switch from highly efficient mitochondrial oxidative phosphorylation (OXPHOS) to low efficiency glycolysis for ATP synthesis even when oxygen is abundant, a phenomenon called the Warburg effect. Because of higher rates cell growth and proliferation, cancer need more than normal same tissues. However, counterintuitive since but prefer use pathway produce ATP. How secure all their needs not well understood. On other hand, extracellular concentration in (intratumoral...