A5046781412- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Musculoskeletal pain and rehabilitation
- Suicide and Self-Harm Studies
- Pharmaceutical studies and practices
- Mental Health Research Topics
- Synthesis and Biological Evaluation
- Mental Health Treatment and Access
- Optimism, Hope, and Well-being
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Spinal Cord Injury Research
- Child and Adolescent Psychosocial and Emotional Development
- Pharmacogenetics and Drug Metabolism
- Chemical Synthesis and Analysis
- Resilience and Mental Health
- Sleep and related disorders
- Neuropeptides and Animal Physiology
- Exercise and Physiological Responses
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
Emory University
2020-2024
Franciscan Hospital for Children
2019-2021
Cincinnati Children's Hospital Medical Center
2021
University of Kentucky
2021
McLean Hospital
2018-2021
Arena Pharmaceuticals (United States)
2018-2019
Harvard University
2018-2019
University of Florida
2005-2014
Florida College
2012-2014
Bristol-Myers Squibb (Germany)
2012
Objective To identify psychological profiles in persons with knee osteoarthritis (OA) and to determine the relationship between these specific pain sensory characteristics, including temporal summation conditioned modulation. Methods Individuals OA (n = 194) completed psychological, health, assessments. Hierarchical cluster analysis was used derive that were compared across several clinical pain/disability experimental responses. Results Cluster 1 had high optimism low negative affect,...
Historically, researchers have proposed higher-order factors to explicate the structure of psychopathology, including Externalizing, Internalizing, Fear, Distress, Thought Disorder, and a general factor. Despite extensive research in this domain, underlying psychopathology remains unresolved. Here, we examine several issues adjudicating among structural models psychopathology. Using simulations analyses extant literature, contrast model-based reliability alternative highlight shortcomings...
The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid 11cc is described (AM803, now GSK2190915). Building upon AM103 (1) (Hutchinson et al. J. Med Chem.2009, 52, 5803-5815; Stock Bioorg. Med. Chem. Lett. 2010, 20, 213-217; Lett.2010, 4598-4601), SAR studies centering around the pyridine moiety led to discovery of compounds that exhibit significantly...
Background: Rodent models of orofacial pain typically use methods adapted from manipulations to hind paw; however, limitations these include animal restraint and subjective assessments behavior by the experimenter. In contrast methods, assessment operant responses painful stimuli has been shown overcome expand breadth interpretation behavioral responses. current study, we used an model based on a reward-conflict paradigm assess nociceptive in three strains mice (SKH1-Hr hr , C57BL/6J, TRPV1...
The potent and selective 5-lipoxygenase-activating protein leukotriene synthesis inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (11j) is described. Lead optimization was designed to afford compounds with superior in vitro vivo inhibition of addition having excellent pharmacokinetics safety rats dogs. key structural features these new are incorporation heterocycles on the indole N-benzyl substituent...
To describe and understand varieties characteristics of sensitization contributing to hyperalgesia in participants with chronic pain conditions.
Age-dependent changes in thermal sensitivity were evaluated with reflex- and operant-based assessment strategies animals ranging age from 8 to 32 months. The impact of inflammatory injury on was also determined different ages. results showed that operant measures escape behavior are needed demonstrate significant across the life span female Long-Evans rats. Increased both heat (44.5°C) cold (1.5°C–15°C) observed for older animals, a greater relative increase cold. Physical performance...
In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing thereby affecting perception by brain. Conventionally, activity evoked is believed be driven glutamate, principle excitatory neurotransmitter in primary afferent fibers. Substance P (SP), prototypic neuropeptide released from fibers horn, regarded as a pain substance mammalian system due its action on nociceptive projection neurons. Here we...
To assess the pharmacokinetics, pharmacodynamics, safety and tolerability of 5-lipoxygenase-activating protein inhibitor, GSK2190915, after oral dosing in two independent phase I studies, one Western European Japanese subjects, utilizing different formulations.Western subjects received single (50-1000 mg) or multiple (10-450 doses GSK2190915 placebo a dose-escalating manner. three four (10-200 plus once period crossover design. Blood samples were collected for concentrations blood urine to...
Few studies in healthy subjects have examined the neuroimmune responses associated with specific experimental pain stimuli, while none has measured multiple biomarkers simultaneously. The aim of present study was to compare neuro-immune following two common stimuli: cold pressor test (CPT) and focal heat (FHP). Eight adults participated counterbalanced sessions FHP or CPT continuous ratings blood sampling before 30 minutes after sessions. Despite similar intensity (FHP = 42.2 ± 15.3; 44.5...
Background The review of collateral information is an essential component patient care. Although this standard practice, minimal research has been done to quantify collection and understand how translates clinical decision making. To address this, we developed piloted a novel measure (the McLean Collateral Information Clinical Actionability Scale [M-CICAS]) evaluate the types number sources viewed resulting actions made in psychiatric setting. Objective This study aims test feasibility...