A5006152429- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Various Chemistry Research Topics
- Crystallography and molecular interactions
- Supramolecular Chemistry and Complexes
- Innovative Teaching Methods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Computational Drug Discovery Methods
- Synthesis and Catalytic Reactions
- Malaria Research and Control
- RNA and protein synthesis mechanisms
- Supramolecular Self-Assembly in Materials
- Magnetism in coordination complexes
- Experimental and Theoretical Physics Studies
- Biomedical and Engineering Education
- Genomics, phytochemicals, and oxidative stress
- Forensic and Genetic Research
- Trypanosoma species research and implications
- Metal-Organic Frameworks: Synthesis and Applications
- Engineering Education and Curriculum Development
- Science Education and Pedagogy
- Cancer, Lipids, and Metabolism
- Education and Critical Thinking Development
- Online and Blended Learning
- Problem and Project Based Learning
University of Edinburgh
2013-2024
University of Strathclyde
2018-2024
University of Bath
2024
International Union of Pure and Applied Chemistry
2011-2019
The development of new antimalarial compounds remains a pivotal part the strategy for malaria elimination. Recent large-scale phenotypic screens have provided wealth potential starting points hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared real time, anyone was able to participate, patents not sought. chemical subseries found exhibit oral activity but contained labile ester that could be replaced...
Cobalt(iii) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(ii) precursor and readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in non-equilibrium state. A preliminary investigation into host-guest chemistry of water-soluble derivative shows it can bind differentiate range different neutral organic molecules. The stability this ensemble also...
The X-ray crystal structure of a previously reported extremely strong quadruple NH···N AAAA-DDDD hydrogen-bond array [5·4] (K(a) = 1.5 × 10(6) M(-1) in CH3CN; K(a) > 3 10(12) CH2Cl2) features four short linear hydrogen bonds. Changing the two benzimidazole groups DDDD unit to triazole replaces bonds with CH···N interactions (complex [5·6]), but only reduces association constant CH3CN by 2 orders magnitude 2.6 10(4) 1 10(7) CH2Cl2). Related complexes without range from 18 270 CH3CN,...
The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved uptake mitochondrial targeting might have increased potential as antitumour agents. studied the effect of a second-generation flavonoid analogue Oncamex panel seven breast lines, applying western blotting, gene expression analysis, fluorescence microscopy immunohistochemistry xenograft tissue to...
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class drug-like physical parameters and synthetically accessible scaffold. We show that the exemplar, OSM-S-106, has potent activity against parasite cultures, mammalian cell toxicity propensity for development. In...
Redox potential is of key importance in the control and regulation cellular function lifecycle, previous approaches to measuring biological redox noninvasively real time are limited areas hypoxia or normoxia. In this paper, we extend our work on nanoparticle-based intracellular nanosensors cover a much wider range -470 +130 mV vs NHE, which includes occupied by cells state oxidative stress. The rationally designed target different monitored surface-enhanced Raman spectroscopy, will permit...
This work further implements the "elements of inquiry" approach in a first-year undergraduate laboratory course, two-part inquiry sequence. In first part sequence, students iteratively develop "best-practice" TLC procedure. second part, optimize simple organic reaction using TLC, making experimental design choices within controlled environment. The has been well-received by and instructors, as reflection real-world research challenges introduced at level.
A polarimeter can be constructed using a document camera as visualizer and standard smartphone screen source of polarized light. pair 3D glasses used polarizing filter, the optical rotation angle liquids measured any free compass app. Consequently, demonstration conducted with no preparation time or specialized equipment.
Employability skills training is an important aspect of undergraduate chemistry degrees to ensure good graduate outcomes for students. In response changes in the employability literature and maintain outcomes, we redeveloped our Year 1 curriculum include a dedicated (GEST) set activities. They were designed created invoke transformative approaches learning, peer group working self-reflection on developing attributes skills. Our assessment effectiveness GEST focused year students' perceptions...
Like most higher education institutions in the U.K., Department of Pure and Applied Chemistry at University Strathclyde Bath adopted online open-book assessment during COVID-19 pandemic, before returning to on-campus hall-based exams several years later. Recognizing potential for issues caused by a lack student familiarity with closed-book exam techniques, we limited form support, inviting students prepare single page notes bring into each exam. The impact this open-note support on anxiety...
Abstract Many pupils who study chemistry in Scotland and intend to progress university undertake a final capstone practical research project as part of their Advanced Higher qualification. This work was suspended for several years due COVID-19, then reintroduced 2023/24. We surveyed 47 Scottish teachers during this first year using mixed-methods survey, found that resource availability had the biggest impact on projects, with over half respondents reporting they asked buy materials third...
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class drug-like physical parameters and synthetically accessible scaffold. We show that the exemplar, OSM-S-106, has potent activity against parasite cultures, mammalian cell toxicity propensity for development. In...
e14071 Background: Clinical trials now underway will assess the use of flavonoids (natural polyphenols) as anticancer agents. Previous work has shown promising antitumor activity Oncamex (a novel myricetin-derived flavonoid with redox properties and mitochondrial targeting) on preclinical breast cancer models suggested role reactive oxygen species (ROS) modulation in these effects. Methods: We evaluated effect at gene level treatment (10µM for 6 h) cell lines representing ER+,...