Choice of solvent is used to direct the formation either hydrogen bonds or halogen in competitive self-assembly.

In contrast to strong hydrogen bonds, halogen bonds are not disrupted by polar solvents.

A previously reported dinuclear DNA imaging probe has been converted into a phototherapeutic through the incorporation of Ru^II(TAP)₂ fragments (TAP = 1,4,5,8-3 tetraazaphenanthrene).

The X-ray crystal structure of a previously reported extremely strong quadruple NH···N AAAA-DDDD hydrogen-bond array [5·4] (K(a) = 1.5 × 10(6) M(-1) in CH3CN; K(a) > 3 10(12) CH2Cl2) features four short linear hydrogen bonds. Changing the two benzimidazole groups DDDD unit to triazole replaces bonds with CH···N interactions (complex [5·6]), but only reduces association constant CH3CN by 2 orders magnitude 2.6 10(4) 1 10(7) CH2Cl2). Related complexes without range from 18 270 CH3CN,...

In previous studies we reported that specific dinuclear RuII complexes are particularly active against pathogenic Gram-negative bacteria and, unusually for this class of compounds, appeared to display lowered activity Gram-positive bacteria. With the aim identifying resistance mechanisms bacteria, uptake and antimicrobial lead complex Staphylococcus aureus SH1000 other isolates, including MRSA was investigated. This revealed differential, strain specific, sensitivity complex. Exploiting...

Advances in supramolecular chemistry are often underpinned by the development of fundamental building blocks and methods enabling their interconversion. In this work, we report use an underexplored dynamic covalent reaction for synthesis stimuli-responsive [2]rotaxanes. The formamidinium moiety lies at heart these mechanically interlocked architectures, because it enables both exchange binding simple crown ethers. We demonstrated that rotaxane self-assembly follows a unique pathway complex...

Within the growing family of strained carbon nanohoops and nanobelts, [10]CPP arguably offers best compromise between synthetic accessibility strong binding affinity for C60. In this work, we report synthesis two nitrogen-containing analogues systematically compare structure, optoelectronic properties C60 affinities small set structurally similar macrocycles. While Aza[10]CPP outcompetes parent compound by approximately one order magnitude with respect to binding, found that reverse was true...

The three stereoisomers of a previously reported dinuclear ruthenium( ii ) complex have been quantitatively separated and it has found the one can be used to track changes in quadruplex DNA content within live cells through its luminescence.

With the aim of developing photostable near-infrared cell imaging probes, a convenient route to synthesis heteroleptic OsII complexes containing Os(TAP)2 fragment is reported. This method was used synthesize dinuclear complex, [{Os(TAP)2}2tpphz]4+ (where tpphz = tetrapyrido[3,2-a:2′,3′-c:3″,2′′-h:2‴,3′′′-j]phenazine and TAP 1,4,5,8- tetraazaphenanthrene). Using combination resonance Raman time-resolved absorption spectroscopy, as well computational studies, excited state dynamics new complex...

Herein we report the separation of three stereoisomers DNA light-switch compound [{Ru(bpy)2}2(tpphz)]4+ (tpphz = tetrapyrido[3,2-a:2',3'-c:3″,2″-h:2‴,3‴-j]phenazine) by column chromatography and characterization each stereoisomer X-ray crystallography. The interaction these compounds with a octanucleotide d(GCATATCG).d(CGATATGC) has been studied using NMR techniques. Selective deuteration bipyridyl rings was needed to provide sufficient spectral resolution characterize structures....

We report a Chan–Lam coupling reaction of benzylic and allylic boronic esters with primary secondary anilines to form valuable alkyl amine products. Both tertiary can be used as partners, mono-alkylation the aniline occurring selectively. This is rare example transition-metal-mediated transformation alkylboron reagent. Initial investigation into mechanism suggests that transmetalation from B Cu occurs through single-electron, rather than two-electron process.

This work demonstrates photocatalytic CO2 reduction by a noble-metal-free photosensitizer-catalyst system in aqueous solution under red-light irradiation. A water-soluble Mn(I) tricarbonyl diimine complex, [MnBr(4,4'-{Et2O3PCH2}2-2,2'-bipyridyl)(CO)3] (1), has been fully characterized, including single-crystal X-ray crystallography, and shown to reduce CO following photosensitization tetra(N-methyl-4-pyridyl)porphyrin Zn(II) tetrachloride [Zn(TMPyP)]Cl4 (2) 625 nm is the first example of 2...

The biological properties of two water-soluble organic cations based on polypyridyl structures commonly used as ligands for photoactive transition metal complexes designed to interact with biomolecules are investigated. A cytotoxicity screen employing a small panel cell lines reveals that both show toward cancer cells but reduced noncancerous HEK293 the more extended system being notably active. Although it is not singlet oxygen sensitizer, active cation also displayed enhanced potency...

The association constants and enthalpies for the binding of hydrogen bond donors to group 10 transition metal complexes featuring a single fluoride ligand (trans-[Ni(F)(2-C5NF4)(PR3)2], R = Et 1a, Cy 1b, trans-[Pd(F)(4-C5NF4)(PCy3)2] 2, trans-[Pt(F){2-C5NF2H(CF3)}(PCy3)2] 3 4 difluorides (Cp2MF2, M Ti 4a, Zr 5a, Hf 6a; Cp*2MF2, 4b, 5b, 6b) are reported. These measurements allow placement these ligands on scales organic H-bond acceptor strength. capability β (Hunter scale) fluorides is far...

Photoelectrochemical devices integrate the processes of light absorption, charge separation, and catalysis for chemical synthesis. The monolithic design is interesting space applications, where weight volume constraints predominate. Hindered gas bubble desorption lack macroconvection in reduced gravitation, however, limit its application space. Physico-chemical modifications electrode surface are required to induce ensure continuous device operation. A detailed investigation electrocatalyst...

A small network of synthetic replicators is capable responding to instructional inputs such that the output an excess one whenever input contains either or both replicators, mirroring OR boolean logic operation.

A reciprocal replication system is constructed from four building blocks, A, B, C, and D, which react in a pairwise manner through either 1,3-dipolar cycloaddition or the condensation reaction between an amine aldehyde to create two templates, trans-TAB TCD. These templates are equipped with complementary recognition sites—two carboxylic acids (trans-TAB) 4,6-dimethylamidopyridines (TCD)—that enable each template direct formation of its partner mutually reinforcing cross-catalytic pathways,...

A new series of chiral 4,5-dihydro-1H-[1,2,4]-triazoline molecules, featuring a β-ᴅ-glucopyranoside appendage, were synthesized via 1,3-dipolar cycloaddition reaction between various hydrazonyl chlorides and carbohydrate Schiff bases. The isolated enantiopure triazolines (8a–j) identified through high-resolution mass spectrometry (HRMS) vibrational spectroscopy. Subsequently, their solution structures elucidated NMR spectroscopic techniques. Single-crystal X-ray analysis derivative 8b...

X-ray structures of the halo-substituted complexes [FeIII (5-X-salMeen)2 ]ClO4 (X=F, Cl, Br, I) [salMeen=N-methyl-N-(2-aminoethyl)salicylaldiminate]at RT have revealed presence two discrete HS complex cations in crystallographic asymmetric unit with perchlorate counter ions linking them by N-Hamine ⋅⋅⋅Operchlorate interactions. At 90 K, are distinctly and LS, a rare observation this coexistence FeIII -salRen (R=alkyl) spin-crossover (SCO) system. both temperatures, crystal packing shows...

A simple complex of copper immobilised on silica exemplifies how lighter transition metal complexes can efficiently kill both Gram-positive and Gram-negative bacteria in water – some cases only 15 min under visible light.

Novel molecular Re and Mn tricarbonyl complexes bearing a bipyridyl ligand functionalised with sterically hindering substituents in the 6,6'-position, [M(HPEAB)(CO)3(X)] (M/X = Re/Cl, Mn/Br; HPEAB 6,6'-{N-(4-hexylphenyl)-N(ethyl)-amido}-2,2'-bipyridine) have been synthesised, fully characterised including by single crystal X-ray crystallography, their propensity to act as catalysts for electrochemical photochemical reduction of CO2 has established. Controlled potential electrolysis showed...

2-Aminoisoindoline-1,3-dione functionalized by Fe3O4@chloro-silane core-shell nanoparticles, then a green and convenient approach for the synthesis of series 4H-pyrans reaction aryl aldehydes, malononitrile methyl acetoacetate in ethanol/60 °C under using magnetic nanoparticles (MNPs) Fe3O4@SiO2-NH-isoindoline-1,3-dione is described. The characterization was performed variety conventional analytical instruments such as Fourier transform infrared spectra, field emission scanning electron...

Synthesis, crystal structures, spectroscopy and magnetic properties of three new bpcam-containing complexes are presented here.

The dithiolene transfer reaction between the nickel bis(dithiolene) complex [Ni(S2C2Ph2)2] and iron carbonyls has been re-investigated, conditions for production of dinuclear product [Fe2(μ-S2C2Ph2)(CO)6] have optimized. Interception a purple intermediate, thought to be [Fe(CO)3(S2C2Ph2)], in [Fe(CO)5] with by addition PPh3 affords new dark blue mononuclear [Fe(CO)2(PPh3)(S2C2Ph2)] good yield. fate fragments these reactions also established crystallographic characterization hexamer...

Tetrahydroisoquinolines are found in many natural products and drug compounds a convenient method to access 1‐substituted derivatives is carry out the lithiation at C‐1 followed by trapping with an electrophile. Here we explore feasibility of C‐3 using substrate benzylic proton on both sides nitrogen atom such that n BuLi could occur either or tetrahydroisoquinoline. The regioselectivity was determined N ‐ tert ‐butoxycarbonyl (Boc)‐3‐phenyltetrahydroisoquinoline. be situ ReactIR...