A5019721311- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- X-ray Diffraction in Crystallography
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- Australian History and Society
- Neurological Disease Mechanisms and Treatments
- Mormonism, Religion, and History
- Chinese history and philosophy
- Synthesis and Catalytic Reactions
- Prion Diseases and Protein Misfolding
- Organophosphorus compounds synthesis
- Computational Drug Discovery Methods
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Oxidative Organic Chemistry Reactions
Normandie Université
2023
University of Bath
2020-2023
Academy of Scientific and Innovative Research
2023
Humboldt-Universität zu Berlin
2023
Central University of Punjab
2023
Central Drug Research Institute
2023
Indian Institute of Engineering Science and Technology, Shibpur
2023
Toronto Metropolitan University
2023
Dr. B. R. Ambedkar National Institute of Technology Jalandhar
2023
Université de Rouen Normandie
2023
Catalytic, intermolecular hydroaminoalkylation (HAA) of styrenes provides a powerful disconnection for pharmacologically relevant γ-arylamines, but current methods cannot utilize unprotected primary alkylamines as feedstocks. Metal-catalyzed HAA protocols are also highly sensitive to α-substitution on the amine partner, and no catalytic solutions exist α-tertiary γ-arylamine synthesis via this approach. We report solution these problems using organophotoredox catalysis, enabling direct,...
Abstract The ubiquity of carboxylic acids as naturally derived or man-made chemical feedstocks has spurred the development powerful, decarboxylative C–C bond-forming transformations for organic synthesis. Carboxylic benefit not only from extensive commercial availability, but are stable surrogates organohalides organometallic reagents in transition-metal-catalysed cross-coupling. Open shell reactivity (or derivatives thereof) to furnish carbon-centred radicals is proving transformative...
We report a Chan–Lam coupling reaction of benzylic and allylic boronic esters with primary secondary anilines to form valuable alkyl amine products. Both tertiary can be used as partners, mono-alkylation the aniline occurring selectively. This is rare example transition-metal-mediated transformation alkylboron reagent. Initial investigation into mechanism suggests that transmetalation from B Cu occurs through single-electron, rather than two-electron process.
The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atmosphere air as terminal oxidant and notably chemoselective. Oxidation C–B bond occurs selectively, even in presence unprotected alcohols. Initial investigation suggests reaction proceeds through alkylboron Cu transmetalation, peroxide formation, rearrangement give carbonyl.
Abstract With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light recent discoveries placing cellular prion protein (PrP C ) as a key player in amyloid β oligomer (Aβo)-induced neurodegeneration, we investigated whether neuroprotective potential nature-inspired flavonoids against Aβ-promoted toxicity would translate into ability to disrupt PrP -Aβo interactions. Hence, synthesized small...
A new approach combining virtual screening,<sup>19</sup>F and STD NMR, biochemical assays using hiPSC targetting multiple pathways involving Aβ, PrP<sup>C</sup>and Tau provides a more effective strategy for Alzheimer's disease drug discovery than Aβ only approach.
Hydroaminoalkylation (HAA) of alkenes is one the most appealing methods for construction α-alkylated amines, and impressive advances in intermolecular HAA non-electrophilic have been made secondary tertiary alkylamine substrates. We recently developed a general catalytic solution with unprotected primary alkylamines using combination organophotoredox catalysis hydrogen atom transfer (HAT) catalysis. Our reaction couples electronically unbiased styrenes alkylamines. The cycle begins...
The Cu-catalysed coupling of arylboronic acids with amines, known as the Chan-Lam reaction, is used widely to prepare aryl amines. In contrast, alkyl variants this while highly desirable, are underdeveloped. Herein, we report a reaction benzylic boronic esters primary and secondary anilines form valuable amine products. Both tertiary can be partners, mono-alkylation aniline occurring selectively. This rare example transition metal-mediated transformation alkylboron reagent. method...
The Cu-catalysed coupling of arylboronic acids with amines, known as the Chan-Lam reaction, is used widely to prepare aryl amines. In contrast, alkyl variants this while highly desirable, are underdeveloped. Herein, we report a reaction benzylic boronic esters primary and secondary anilines form valuable amine products. Both tertiary can be partners, mono-alkylation aniline occurring selectively. This rare example transition metal-mediated transformation alkylboron reagent. method...
The Cu-catalysed coupling of arylboronic acids with amines, known as the Chan-Lam reaction, is used widely to prepare aryl amines. In contrast, alkyl variants this while highly desirable, are underdeveloped. Herein, we report a reaction benzylic boronic esters primary and secondary anilines form valuable amine products. Both tertiary can be partners, mono-alkylation aniline occurring selectively. This rare example transition metal-mediated transformation alkylboron reagent. method...