A5018182814- Research on Leishmaniasis Studies
- X-ray Diffraction in Crystallography
- Trypanosoma species research and implications
- Crystallization and Solubility Studies
- Higher Education and Employability
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Various Chemistry Research Topics
- Crystallography and molecular interactions
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Antimicrobial agents and applications
- Chemistry and Chemical Engineering
- Mathematics Education and Programs
- Helminth infection and control
- Tuberculosis Research and Epidemiology
- Engineering Education and Curriculum Development
- Career Development and Diversity
- Science Education and Pedagogy
- Legionella and Acanthamoeba research
- Higher Education Learning Practices
- HIV/AIDS drug development and treatment
- Parasites and Host Interactions
- Student Assessment and Feedback
University of Strathclyde
2014-2024
International Union of Pure and Applied Chemistry
2011-2020
Glasgow Life
2019-2020
University of Huddersfield
2017-2019
University of Lincoln
2017
Hamilton Health Sciences
1990
In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases the continuing identification defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed these organisms. We approached this matter in a novel manner by synthesizing library drug-like small molecules based upon phosphorylcholine, active moiety Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is...
Recognising the importance of graduates being equipped with appropriate employability skills alongside their subject-specific skills, we have had transferable training embedded throughout our degree programmes for 30 years. More recently, a specific module final-year honours students has been created. This consists programme activities supporting which was delivered to undergraduate from 2012 2015. A key feature in development and delivery these involvement external experts. Detailed...
We describe the evaluation of Cyrene™ as an alternative to DMSO a vehicle for antibacterial susceptibility testing.
For many years, a key driver for Higher Education Institutions (HEIs) has been ensuring that students are prepared employment post-graduation. This often resulted in HEIs providing specific modules of study focussing on employability and soft skills. The existing research literature presents variety strategies embedding within curricula, focusing frameworks to review the provision opportunities degree programme. authors have previously investigated an module Undergraduate Chemistry Programme...
Mathematical ability is a major contributory factor to the success of student in any science course. This paper aims determine source difficulty that students often find when performing calculations chemistry. Through design and analysis set chemistry questions analogous mathematics questions, Standard Grade context, it revealed basic grasp missing.
A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in nanomolar range, and represent hits further optimisation towards novel treatments Human Animal African Trypanosomiases. Moreover, SAR indicates that head group linking moiety is a modulator biological activity.
MGB-BP-3 is a potential first-in-class antibiotic, Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides difficile associated disease. Its precise mechanism action and origin limited activity against Gram-negative pathogens are relatively unknown. Herein, with alone significantly inhibited bacterial growth Gram-positive, but not Gram-negative, bacteria as expected. Synergy assays revealed inefficient...
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based minor groove binders (MGBs), such as the diamidines, which have been used decades, now lost efficacy in some places emergence resistant parasites. Consequently, need new chemotherapies urgent. Here, we describe structurally distinct class MGBs, Strathclyde MGBs (S-MGBs), display excellent vitro activities...
The slow development of major advances in drug discovery for the treatment Mycobacterium tuberculosis (Mtb) infection suggests a compelling need evaluation more effective therapies against TB. New classes drugs are constantly being evaluated anti-mycobacterial activity with currently very limited number new approved TB treatment. Minor groove binders (MGBs) have previously revealed promising antimicrobial various infectious agents; however, they not yet been screened Mtb.The mycobactericidal...
Acanthamoeba spp. is the causative agent of keratitis and granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a promising new class anti-infective that have been shown to be effective against many infectious organisms.
Riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine pyrophosphate (TPP), involved in the regulation of metabolism numerous bacteria. As these regulatory RNAs often modulating essential biosynthesis pathways they have become increasingly interesting as promising antibacterial targets. Here, we describe analogs containing a central 1,2,3-triazole group induce repression thiM-riboswitch...
We describe the synthesis and evaluation of Strathclyde Minor Groove Binders (S-MGBs) as selective anti-cancer agents which act through a non-alkylating mechanism.
Abstract Background Previously, we evaluated the intracellular mycobactericidal activity of minor groove binder, S-MGB-364 against clinical Mycobacterium tuberculosis (Mtb) strain HN878 in macrophages. Objectives To assess Mtb-infected mice. Further, investigated a plausible DNA binding mechanism action S-MGB-364. Methods The anti-TB and host immune effects intranasal or encapsulated non-ionic surfactant vesicles (NIV) were assessed mice by cfu enumeration, ELISA, histology, flow cytometry....
Like most university learners, students in the Department of Pure and Applied Chemistry at University Strathclyde, experienced hybrid learning environments from March 2020 transitioning into approaches for full academic year 21/22. As who were early years their programme this time, a shift traditional education practices are soon to graduate, short research project was undertaken better understand perception employers on impact remote current, future, graduate skills, competencies. Several...
There were an estimated 249 million cases of malaria globally in 2022, causing approximately 608 000 deaths. Most these are attributed to infection by
An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up 80 °C an anti-parallel, head-to-tail orientation as found binding duplex oligomers.