A5033408989- Cannabis and Cannabinoid Research
- Crystallization and Solubility Studies
- Gastrointestinal motility and disorders
- Pain Mechanisms and Treatments
- X-ray Diffraction in Crystallography
- Microbial Inactivation Methods
- Pharmaceutical Economics and Policy
- 3D Printing in Biomedical Research
- Health Systems, Economic Evaluations, Quality of Life
- Psychedelics and Drug Studies
- Circadian rhythm and melatonin
- Economic and Financial Impacts of Cancer
- Cellular Mechanics and Interactions
- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Inflammatory mediators and NSAID effects
- Cancer Research and Treatments
- Planarian Biology and Electrostimulation
- Saffron Plant Research Studies
- Pancreatic function and diabetes
- Click Chemistry and Applications
- Restless Legs Syndrome Research
- Prenatal Substance Exposure Effects
- Cancer, Lipids, and Metabolism
- Flavonoids in Medical Research
University of Huddersfield
2016-2025
Kharazmi University
2021
University of Bradford
1999-2020
Baqiyatallah University of Medical Sciences
2016
To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting enhance 5-HT(1A) receptor activation in animal models.We investigated effect CBDA on (i) lithium chloride (LiCl)-induced conditioned gaping a flavour (nausea-induced behaviour) or context (model anticipatory nausea) rats; (ii) saccharin palatability (iii) motion-, LiCl- cisplatin-induced house musk shrews (Suncus murinus); (iv) rat brainstem by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) mouse whole...
Abstract Parkinson’s disease (PD) is a complex, progressive neurodegenerative disorder with high heterogeneity, making early diagnosis difficult. Early detection and intervention are crucial for slowing PD progression. Understanding PD’s diverse pathways mechanisms key to advancing knowledge. Recent advances in noninvasive imaging multi-omics technologies have provided valuable insights into underlying causes biological processes. However, integrating these data sources remains challenging,...
Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity transcription factor nuclear erythroid 2-related 2 (Nrf2) by stalling its ubiquitination and degradation. This enhances expression genes encoding proteins involved in drug detoxification, redox homeostasis, mitochondrial function. Nrf2 activation offers a potential therapeutic approach for conditions including Alzheimer's Parkinson's diseases, vascular inflammation, chronic obstructive airway disease....
Abstract: The effect of cannabinoids on motion‐induced emesis is unknown. present study investigated the action phytocannabinoids against in Suncus murinus . were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Δ 9 ‐tetrahydrocannabinol (Δ ‐THC; 0.5, 3, 5 10 mg/kg) or vehicle 45 min. before exposure to a 10‐min. horizontal motion stimulus (amplitude mm, frequency 1 Hz). In further investigations, CB receptor antagonist, N‐...
Depression is one of the most frequent psychiatric disorders in world with occurs higher incidence women. In present study, effect water-alcoholic extract Papaver rhoeas L. on forced swimming test (FST) Swiss-Webster mice were examined.We used (20-25 g) to execute FST them. The plant (1, 10, 30, and 100 mg/kg) was injected animals 30 minutes before each session. Fluoxetine (20 as standard antidepressant drug. another group animals, after administration, blood samples taken from retro-orbital...
Crocus sativus and its bioactive constituent crocin are well known for anti-tumor potential in different models. However, the efficacy of on in-vivo melanoma metastasis is not yet reported. In this study, metastatic model was developed by tail vein injection B16F-10 cells to C57BL/6 mice. Metastatic mice treated with two doses (250 500 μg/kg bodyweight) 10 days parameters such as lung inhibition, mean survival time, hydroxyproline, uronic acid hexosamine levels were analyzed after 21...
Ovarian cancer represents the seventh most commonly diagnosed worldwide. Herein, we report on development of a withaferin A (WA)-silyl ether library with 30 analogues reported for first time. Cytotoxicity assays human epithelial ovarian carcinoma cisplatin-sensitive and -resistant cell lines identified eight displaying nanomolar potency (IC50 ranging from 1 to 32 nM), higher than that lead compound reference drug. This cytotoxic is also coupled good selectivity index nontumoral line. Cell...
Colon cancer is the most aggressive form of cancers, that causes 0.5 million deaths per year around globe. Targeting colon by conventional therapeutic options elicits toxicity. Traditional medicines take a lead to alleviate existing clinical challenges.To investigate antibacterial activity against Helicobacter Pylori and in vitro anti-colon Acacia nilotica extract (ACE) its active constituent pyrogallol.Pyrogallol isolated from A. column chromatography HPLC structure was elucidated spectral...
Abstract This paper reports on the development of an entirely new intestinal smooth muscle cell (ISMC) culture model using rat neonates for use in pharmacological research applications. Segments duodenum, jejunum and ileum were obtained from Sprague‐Dawley neonates. The extraction technique consisted ligating both ends intestine incubating (37 ºC) 0.25% trypsin periods 30–90 min. Isolated cells suspended DMEM‐HEPES, plated allowed to proliferate 7 days. Cell quality was assessed via a series...
We describe the synthesis and evaluation of Strathclyde Minor Groove Binders (S-MGBs) as selective anti-cancer agents which act through a non-alkylating mechanism.
Abstract Cannabinoids have been shown to induce anti‐tumor activity in a variety of carcinoma cells such as breast, prostate, and brain. The aim the present study is investigate cannabinoids, CBD (cannbidiol), CBG (cannabigerol) ovarian sensitive resistant chemotherapeutic drugs. Sensitive A2780 A2780/CP70 non‐carcinoma were exposed varying concentrations CBD, CBG, carboplatin or CB 1 2 receptor antagonists, AM251 AM630, respectively, alone combination, at different exposure times...
Isothiazoles (I) reacted with 1,3-dipoles or NaN<sub>3</sub> to give cycloadducts (II) thiazete (III). Thiazete (III) rearranged 1,2,3-oxathiazoline (IV).