A5103133080- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive natural compounds
- Diverse Scientific Research Studies
- Advanced Drug Delivery Systems
- COVID-19 epidemiological studies
- Phytochemistry and Biological Activities
- Curcumin's Biomedical Applications
- Animal Disease Management and Epidemiology
- Medical and Biological Ozone Research
- Medicinal Plants and Bioactive Compounds
- Toxin Mechanisms and Immunotoxins
- Research on Leishmaniasis Studies
- Echinoderm biology and ecology
- Polysaccharides and Plant Cell Walls
- Synthesis and Biological Evaluation
- Hops Chemistry and Applications
- Seaweed-derived Bioactive Compounds
- Antibiotic Use and Resistance
National Research Centre
2020-2025
National Water Research Center
2022-2023
Al-Azhar University
2020
(1) Background: Drug repositioning is an unconventional drug discovery approach to explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue alleviate the COVID-19 pandemic disease. (2) Methods: Herein, we tested antiviral activity anti-microbial and anti-inflammatory Food Administration (FDA)-approved drugs, commonly prescribed relieve respiratory symptoms, against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), viral causative agent pandemic....
Flavonoids are important secondary plant metabolites that have been studied for a long time their therapeutic potential in inflammatory diseases because of cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from the hydrolyzed aqueous methanol extracts Anastatica hierochuntica L., Citrus reticulata Blanco, Kickxia aegyptiaca (L.) Nabelek. They as taxifolin (1), pectolinarigenin (2), tangeretin (3), gardenin B (4), hispidulin (5). These structures elucidated...
Abstract During the current coronavirus disease 2019 (COVID-19) pandemic, symptoms of depression are commonly documented among both symptomatic and asymptomatic quarantined COVID-19 patients. Despite that many FDA-approved drugs have been showed anti-SARS-CoV-2 activity in vitro remarkable efficacy against clinical trials, no pharmaceutical products yet declared to be fully effective for treating COVID-19. Antidepressants comprise five major drug classes treatment depression, neuralgia,...
Since the emergence of SARS-CoV-2 at end 2019, 64 candidate vaccines are in clinical development and 173 pre-clinical phase. Five types currently approved for emergency use many countries (Inactivated, Sinopharm; Viral-vector, Astrazeneca, Gamaleya Research Institute; mRNA, Moderna, BioNTech/Pfizer). The main challenge this pandemic was availability to produce an effective vaccine be distributed world’s population a short time. Herein, we developed whole virus NRC-VACC-01 inactivated tested...
SARS CoV-2 is still considered a global health issue, and its threat keeps growing with the emergence of newly evolved strains. Despite success in developing some vaccines as protective measure, finding cost-effective treatments urgent. Accordingly, we screened number phenolic natural compounds for their vitro anti-SARS activity. We found sinapic acid (SA) selectively inhibited viral replication an half-maximal inhibitory concentration (IC50) value 2.69 µg/mL significantly low cytotoxicity...
Several natural products recovered from a marine-derived
We detected highly pathogenic avian influenza A(H5N1) virus in wild rats collected from a rural area Giza, Egypt, near poultry farms, markets, and backyard flocks. Sequence phylogenetic analyses indicated that the belonged to clade 2.3.4.4b, which has been predominant genotype circulating Egypt worldwide since 2021-2022. Active surveillance of viruses domestic mammals is recommended prevent further spread humans.
Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt, June 2024. Genomic phylogenetic analyses revealed a novel genotype produced by reassortment of an A(H5N1) 2.3.3.4b virus with A(H9N2) G1-like virus. Monitoring the spread this is important.
Unexpected mutations in SARS-CoV-2 produce unique variations. While numerous vaccines and antiviral medications are available for SARS-CoV-2, their use controlling preventing COVID-19 is restricted some areas countries due to accessibility cost issues. This study investigated polysaccharides produced from two brown seaweed (Padina boergesenii Sargassum euryphyllum) capacity inhibit SARS-CoV-2. The were characterized identified using ultraviolet visible (UV/VIS) Fourier transform infrared...
SARS-CoV-2 virus is transmitted in closed settings to people contact with COVID-19 patients such as healthcare workers and household contacts. However, person-to-person transmission studies are limited. Households participating an ongoing cohort study of influenza incidence prevalence rural Egypt were followed. Baseline enrollment was done from August 2015 March 2017. The protocol amended April 2020 allow seroprevalence studies. A total 290 households including 1598 participants enrolled...
Coronaviruses emerged three times in the last two decades and became a source of concern globally. Humulus lupulus plant has been used widely medical science. Our objective this study was to determine effects crude extract H. inhibiting MERS-CoV SARS-CoV-2 viruses' replication vitro using Vero E6 cell lines predict antiviral activity its identified compounds against receptor binding (RBD) protein both viruses silico. We determined concentration that induced less than 50% toxicity (CC50),...
The anti-MERS-CoV activities of three medicinal plants (Azadirachta indica, Artemisia judaica, and Sophora tomentosa) were evaluated. highest viral inhibition percentage (96%) was recorded for S. tomentosa. Moreover, the mode action both tomentosa A. judaica showed 99.5% 92% inhibition, respectively, with virucidal as main action. Furthermore, anti-SARS-CoV-2 measured. Notably, activity very high (100%) slightly lower (96%). Therefore, phytochemical investigation promising L. led to...
Abstract 3,5‐Di[( E )‐arylidene]‐1‐[3‐(4‐methylpiperazin‐1‐yl)alkyl]piperidin‐4‐ones 7 a−k were synthesized through dehydrohalogenation of 1‐(2‐chloroacyl)piperidin‐4‐ones 5 with N ‐methylpiperazine ( 6 ). High antiproliferation potencies observed by most the agents against both HCT116 (colon) and MCF7 (breast) cancer cell lines relative to standard references (sunitinib 5‐fluorouracil). The are dual activity topoisomerases I IIα however, higher efficacy topoisomerase rather than I....
Abstract Owing to its high interest as prolific source of diverse bioactive compounds referred in our previous research work, we have scaled-up the fermentation marine Aspergillus terreus LGO13 on a liquid culture medium isolate and identify very minor/further promising secondary metabolites study their antibacterial, cytotoxic, antiviral properties. Twenty-three known metabolites, including recently discovered microbial natural product N -benzoyl-tryptophan ( 1 ), were obtained herein....
Abstract The search for new molecules targeting SARS-CoV-2 has been a priority since 2020. continuous evolution of mutants increases the need more research in area. One way to find leads is repurpose existing drugs and against required target. Here, we present vitro silico screening ten previously synthesized reported compounds as anti-COVID 19 agents. were screened VERO-E6 cells their Cytotoxic Concentration (CC 50 ) Inhibitory (IC ). Compounds 1 , 2 5 revealed promising anti-SARS-CoV-2 =...
Since its first isolation from migratory birds in Egypt 2016, highly pathogenic avian influenza (HPAI) H5N8 has caused several outbreaks among domestic poultry various areas of the country affecting health and production systems. However, genetic biological properties HPAI viruses have not been fully elucidated yet. In this study, we aimed to monitor evolution circulating identify pathogenicity mammalian adaptation vitro vivo . Three were used study isolated 2021–2022 wild during our routine...
During the past two decades, several human infections with avian influenza H5N1 virus have been reported. An increase in recorded cases of viral led to more public health concern, because their potential pandemic proportions human's society. Moreover, an drug-resistant A has brought urgent need for alternative anti-influenza drugs. In present study, water extracts from eight commonly available medicinal and nutritive plants Apiaceae family including; Dill, Celery, Caraway, Coriander, Cumin,...
Reported laboratory-confirmed COVID-19 cases underestimate the true burden of disease as without laboratory confirmation, and asymptomatic mild are missed by local surveillance systems. Population-based seroprevalence studies can provide better estimates taking into account infections that were Additionally, little is known about determinants seroconversion in community settings.