1. The present experiment was undertaken to investigate the influence of oral creatine supplementation, shown previously increase total content human skeletal muscle (Harris RC, Soderlund K, Hultman E. Clin Sci 1992; 83: 367-74), on isokinetic torque and accumulation plasma ammonia blood lactate during five bouts maximal exercise. 2. Twelve subjects undertook 30 voluntary contractions, interspersed with 1 min recovery periods, before after 5 days placebo (4 x 6 g glucose/day, n = 6) or plus...

Nine male subjects performed two bouts of 30-s maximal isokinetic cycling before and after ingestion 20 g creatine (Cr) monohydrate/day for 5 days. Cr produced a 23.1 +/- 4.7 mmol/kg dry matter increase in the muscle total (TCr) concentration. Total work production during 1 2 increased by approximately 4%, cumulative increases both peak over exercise were positively correlated with TCr. Cumulative loss ATP was 30.7 12.2% less ingestion, despite production. Resting phosphocreatine (PCr) type...

The aim of this study was to determine whether consumption a diet containing 8.5 g carbohydrate (CHO) x kg(-1) day(-1) (high CHO; HCHO) compared with 5.4 CHO (control; Con) during period intensified training (IT) would result in better maintenance physical performance and mood state. In randomized cross-over design, seven trained runners [maximal O(2) uptake (Vo(2 max)) 64.7 +/- 2.6 ml min(-1)] performed two 11-day trials consuming either the Con or HCHO diet. last week both consisted IT....

We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following control days, day 4, subjects 60 min running at 55%, 65%, 75% Vo(2max). Markers resorption [COOH-terminal telopeptide region collagen type 1 (β-CTX)] formation [NH(2)-terminal propeptides procollagen (P1NP),...

This study investigated the effect of carbohydrate (CHO) ingestion on postexercise glycogen resynthesis, measured simultaneously in liver and muscle ( n = 6) by 13 C magnetic resonance spectroscopy, subsequent exercise capacity 10). Subjects cycled at 70% maximal oxygen uptake for 83 ± 8 min six separate occasions. At end exercise, subjects ingested 1 g/kg body mass (BM) glucose, sucrose, or placebo (control). Resynthesis over a 4-h period after treatment was first three occasions, occasions...

Strenuous exercise increases bone resorption but not formation. The effect of improved training status is unknown.Our objective was to examine the metabolic response strenuous running in recreationally active (RA) and endurance-trained (ET) men.Eleven RA, 10 ET, control (CON) subjects completed one 8-d trial. On d 4, RA ET an exhaustive treadmill run. Blood obtained at baseline (BASE), during exercise, 2 h recovery, on four follow-up (FU) days (FU1-FU4). CON rested throughout, providing...

Summary and Conclusions1. Mammary carcinoma Eo771 was inoculated into 529 C-57 black mice in three series of experiments. Tumor growth 109 control (12 experiments) injected with one Bar Harbor mammary strain averaged 2.7 cc at 19-20 days, 41 the same (4 previously heterologous XYZ material 2.5 days. An additional 106 11 experiments a second received from about 1 year later 20 indicating great uniformity 2 different strains this tumor Carworth Farms C57 mice, there being no statistically...

The Brown-Pearce rabbit tumor is a transplantable malignant epithelioma carried in this laboratory for more than 100 generations by intratesticular inoculation. It has been used extensively the study of animal constitution and it found possible to alter susceptibility or resistance animals various surgical environmental procedures. About year half ago attempts were made inoculation with use material derived from itself. essential feature concerned preparation conjunction regular first...

This study investigated the effect of insulin on plasma and muscle creatine accumulation limb blood flow in humans after administration. Seven men underwent a 300-min euglycemic clamp combined with administration four separate occasions. Insulin was infused at rates 5, 30, 55, or 105 mU ⋅ m −2 min −1 , each occasion 12.4 g administered. During infusion 55 total concentration increased by 4.5 ± 1.4 ( P < 0.05) 8.3 1.0 mmol/kg dry mass 0.05), concentrations were lower specific time points...

Nine male subjects performed two bouts of 30-s maximal isokinetic cycling. Each bout exercise was at 80 revolutions/min and separated by 4 min recovery. Mixed-muscle phosphocreatine (PCr) resynthesis during recovery (88.1 +/- 6.1%) positively correlated with the restoration total work production 2 (r = 0.80, P < 0.05). During 1, ATP PCr utilization were greater in type II compared I fibers (P 0.01 0.05, respectively). The subsequent 4-min period insufficient to allow fibers, but almost...

Background —The use of creatine (Cr) as a nutritional supplement to aid athletic performance has gained widespread popularity among athletes. However, concerns have recently been expressed over potentially harmful effects short and long term Cr supplementation on health. Methods —Forty eight young healthy subjects were randomly allocated three experimental protocols aimed at elucidating any potential health risks associated with five days (20 g/day) nine weeks (3 supplementation. Venous...

We compared the effects of exercise intensity (EI) on cytokine response to an acute bout running.Ten males (mean ± SD VO(2max)= 56.2 8.1 mL·min(-1)·kg(-1)) completed three, counterbalanced, 8-d trials. After three control days, day 4, participants 60 min running at 55%, 65%, and 75% VO(2max). The cytokines tumor necrosis factor (TNF)-α, interleukin-1β (IL-1β), IL-6, IL-1 receptor antagonist (ra), creatine kinase were measured during for 3 h after four follow-up days (FU1-FU4).RER was higher...

The aim of this work was to investigate the effect a daily mixed nutritional supplement upon body composition, physical performance, and circulating anabolic hormones in soldiers undergoing arduous training. Thirty males received either habitual diet alone (CON, n = 15) or with addition (SUP, ∼5.1 MJ·d –1 during 8 weeks Body composition (DEXA), maximal dynamic lift strength (MDLS), vertical jump (VJ) were assessed, resting blood samples collected before after Blood analysis included...

Muscle glycogen availability can limit endurance exercise performance. We previously demonstrated 5 days of creatine (Cr) and carbohydrate (CHO) ingestion augmented post-exercise muscle storage compared to CHO feeding alone in healthy volunteers. Here, we aimed characterise the time-course this Cr-induced response under more stringent controlled experimental conditions identify potential mechanisms underpinning phenomenon. Fourteen healthy, male volunteers cycled exhaustion at 70 % VO2peak....

The use of supplements is widespread at all levels civilian sport and a prevalence 60-90 % reported among high-performance UK athletes, including juniors. supplement UK-based British Army personnel not known. aim the present study was to establish point in soldiers under training (SuTs) associated staff. A cross-sectional anonymous survey carried out 3168 SuTs soldiers, equating 3·1 regular strength, based eleven Phase 1, 2 3 sites. Overall, 38 respondents current supplements, but varied...

1. Studies investigating muscle glycogen resynthesis in man have usually examined mixed-fibred biopsies or used histochemical methods to estimate single fibre resynthesis. Since the accuracy of latter is open debate, this study investigated type I and II fibres using biochemical analysis. 2. Seven subjects performed one-legged cycling exercise exhaustion. During initial 2 h recovery, consumed 3 g glucose (kg body mass (BM))-1, a high carbohydrate diet thereafter. Muscle biopsy samples were...