A5061895478- Heme Oxygenase-1 and Carbon Monoxide
- Alcohol Consumption and Health Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Folate and B Vitamins Research
- Neonatal Health and Biochemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Cancer, Lipids, and Metabolism
- Photoreceptor and optogenetics research
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Corrosion Behavior and Inhibition
- Trace Elements in Health
- Cardiac Ischemia and Reperfusion
- Helicobacter pylori-related gastroenterology studies
- Genomics and Rare Diseases
- Aldose Reductase and Taurine
- Hydrogen embrittlement and corrosion behaviors in metals
- Structural Integrity and Reliability Analysis
- Lipid metabolism and disorders
Xinxiang Medical University
2012-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Nanjing University of Chinese Medicine
2024
Henan Psychiatric Hospital
2002-2022
Xi'an University of Architecture and Technology
2020
Childhood absence epilepsy (CAE) is a subtype of idiopathic (genetic) generalized epilepsies (IGEs). In this study, four heterozygous variants in CLCN2 were found 10 CAE patients using whole exome sequencing (WES). We used genetics, bioinformatics, molecular biology, and electrophysiology to study the variants. Bioinformatics analysis showed that probably damaging, c.1141C > G (p.Pro381Ala) c.1885C T (p.Arg629Cys) affected tertiary structure ClC-2 chloride channel. Functional studies variant...
To investigate the influence of Helicobacter pylori (HP) infection on carotid atherosclerosis (AS) in physical examination population. This study included patients from First Affiliated Hospital Xinjiang Medical University (May 2021-May 2023). Participants underwent a carbon-13 urea breath test (13C-UBT), HP antibody detection, and AS assessment via colour Doppler ultrasound. The were divided into HP-infected group non-infected based 13C-UBT results, with further subdivided high-risk...
Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is more characteristic of anoxic than other types anoxia. Those who have the same degree and are similar age gender a greater risk getting DEACMP. This has made it clear that there obvious personal differences. Genetic factors may play very important role. The authors performed genome-wide association study involving pooling DNA obtained from 175 patients 244 matched without delayed controls. Illumina HumanHap 660 Chip...
The aim of the present study was to identify effect heme oxygenase (HO)-1 gene on cerebral ischemia-reperfusion injury. Sprague-Dawley rats were divided randomly into four groups: Sham group, vehicle empty adenovirus vector (Ad) group and recombinant HO-1 (Ad-HO-1) transfection group. Rats in vehicle, Ad Ad-HO-1 groups respectively injected with saline, or for 3 days prior Subsequently, middle artery occlusion method used establish model Following assessment neurological function,...
The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) provide a theoretical basis for DEACMP pathogenesis, diagnosis, prognosis. To investigate relationship, we screened 6 NSE single nucleotide polymorphisms (SNPs), based on results previous genome-wide association studies (GWAS). A total 1,201 patients, including 416 in group 785 (ACMP) group, were detected by...
Delayed neuropsychological sequelae (DNS) are the most severe and clinically intractable complications following acute carbon monoxide (CO) poisoning. Symptoms of DNS often resemble those Parkinson’s disease (PD), suggesting shared neurological deficits. Furthermore, Parkinson protein 2 (PARK2) mutations associated with PD other neurodegenerative diseases. The association signal was detected between PARK2 after CO poisoning in our DNA pooling base genome-wide study. Two single nucleotide...
There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP).In order assess role genetic factors this mechanism, we studied association between tumor necrosis factor-α308 (TNF-α308) basic protein (MBP) 5ꞌ-side tetranucleotide repetitive sequence (TGGA) n gene polymorphism DEACMP.We selected 109 DEACMP patients from Han population Northern Henan Province as case group, 115 without (called CO...
目的 探讨急性一氧化碳中毒后迟发性脑病(delayed encephalopathy after acute carbonmonoxide poisoning,DEACMP)患者血清中白细胞介素(IL)-1β、IL-8、IL-10水平的动态变化,为进一步研究DEACMP的发病机制提供线索.方法 用日常生活能力量表(ADL)、常识-记忆-注意测验(IMCT)、长谷川痴呆量表(HDS)动态检查DEACMP患者的病情变化,同时应用酶联免疫吸附法(ELISA)动态测定其血清中IL-1β、IL-8、IL-10水平,并与28例急性一氧化碳中毒后未发生迟发性脑病患者、23例其他原因痴呆患者和26例正常对照者进行比较.结果 DEACMP患者发病初期血清中lL-1β、IL-8、IL-10水平明显高于急性一氧化碳中毒组、其他原因痴呆组和正常对照组,差异有统计学意义(P<0.05);DEACMP患者恢复期血清中IL-1β、IL-8、IL-10水平明显低于发病初期,差异有统计学意义(P<0.01).结论 DEACMP的发生机制与神经免疫损伤有关,细胞因子参与了疾病的病理生理学机制。
Antiepileptic drugs are the first choice of treatment for patients with epilepsy. However, withdrawal antiepileptic after seizure-free remains a significant focus majority epilepsy and their families. In this study, we evaluated risk factors associated relapse drug in seizure free 2 years. We aimed to guide assess withdrawal.Through screening, 452 were included study.Patients followed up at least years or more. Analyzed clinical data by applying χ2-test, Kaplan-Meier survival analysis...
Parkinson's disease (PD) is a common neurological degenerative that cannot be completely cured, although drugs can improve or alleviate its symptoms. Optogenetic technology, which stimulates inhibits neurons with excellent spatial and temporal resolution, provides new idea approach for the precise treatment of disease. However, neural mechanism photogenetic regulation remains unclear. In this paper, we want to study nonlinear features EEG signals in striatum globus pallidus through...
Objective: To investigate the association of WWP2 single nucleotide polymorphism (rs3790088, rs4247109) with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) , and explore influences DEACMP genetic predisposition. Methods: From November 2006 to December 2017, 235 cases 429 (ACMP) were selected. All ACMP patients followed up for more than 90 days without DEACMP. The DNA in all blood samples extracted Genome Extraction Kit. method Sequenom Mass Array SNP technique was used...
Objective. The purpose of this study was to analyze the relationship between cadherin gene single-nucleotide polymorphisms (SNPs) and risk delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Materials Methods. A total 416 patients with DEACMP 754 (ACMP) were recruited. We used Sequenom MassARRAY® system detect SNPs related DEACMP. Using different genetic analysis models, we evaluated Results. found that rs1944294 in N-cadherin (CDH2) showed significant differences genotype...
Abstract Background Increasing evidence reveals that delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) results from the combined effects of environmental and genetic factors. The main pathological feature DEACMP was generalized demyelination cerebral white matter. Myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) serum samples patients were elevated. Objectives This study investigated association MBP single nucleotide polymorphisms(SNPs) (rs470555, rs470724,...