A5002384063- Heme Oxygenase-1 and Carbon Monoxide
- Amyotrophic Lateral Sclerosis Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Hedgehog Signaling Pathway Studies
- Iron Metabolism and Disorders
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Oral and gingival health research
- Aldose Reductase and Taurine
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Genetics and Neurodevelopmental Disorders
Shanxi Medical University
2010-2024
Second Hospital of Shanxi Medical University
2015-2022
First Affiliated Hospital of Zhengzhou University
2017
The Sonic Hedgehog (SHH) signaling pathway is related to the progression of various tumors and nervous system diseases. Still, its specific role in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), remains studied. This research investigates SHH PI3K/AKT proteins on ALS development a SOD1-G93A transgenic mouse model. After injection inhibitors or agonists hSOD1-G93A (9 weeks age) mice, we studied skeletal muscle pathology using immunohistochemical staining Western blot...
The aim of the present study was to identify effect heme oxygenase (HO)-1 gene on cerebral ischemia-reperfusion injury. Sprague-Dawley rats were divided randomly into four groups: Sham group, vehicle empty adenovirus vector (Ad) group and recombinant HO-1 (Ad-HO-1) transfection group. Rats in vehicle, Ad Ad-HO-1 groups respectively injected with saline, or for 3 days prior Subsequently, middle artery occlusion method used establish model Following assessment neurological function,...
Amyotrophic lateral sclerosis (ALS) is an irreversible neurodegenerative disease that involves the spinal cord and then causes reduced function of extremities, eventually often respiratory muscles leads to death, 10% cases are related family inheritance, most frequent gene mutation SOD1. In hSOD1G93A transgenic mice using Western Blot immunohistochemistry techniques we found expression SHH, FAK, ERK, p-FAK, p-ERK was progressively decreased in tissue hSOD1 over time. By stimulating SHH with...
Objective:The study aimed to investigate the efficacy of sublingual immunotherapy(SLIT) in treatment adult allergic rhinitis, and explore predictive role baseline serum cytokine levels its therapeutic effect.Method:Sixty patients with moderatesevere perennial AR sensitized house dust mites were treated for 2 years. The SLIT group(n=30) standardized mite vaccine conventional drugs, control placebo drugs. combined symptom medication score(CSMS) compared between two groups evaluate at year...
Abstract Amyotrophic lateral sclerosis (ALS) is an irreversible neurodegenerative disease that involves the spinal cord and then causes reduced function of extremities, eventually often respiratory muscles leads to death, 10% cases are related family inheritance, most frequent gene mutation SOD1. In hSOD1G93A transgenic mice using Western Blot immunohistochemistry techniques we found expression SHH, FAK, ERK, p-FAK, p-ERK was progressively decreased in tissue hSOD1 over time. By stimulating...