A5042248372- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Blood groups and transfusion
- Blood transfusion and management
- Global Health Workforce Issues
- Complement system in diseases
- Infective Endocarditis Diagnosis and Management
- Erythrocyte Function and Pathophysiology
- Dental Education, Practice, Research
- Mosquito-borne diseases and control
- Cultural Competency in Health Care
- Streptococcal Infections and Treatments
- Ethics in Clinical Research
- Diabetes and associated disorders
- Acute Myeloid Leukemia Research
- Marine Invertebrate Physiology and Ecology
- Bioactive Natural Diterpenoids Research
- Cardiac Arrest and Resuscitation
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Erythropoietin and Anemia Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diversity and Career in Medicine
- Hematopoietic Stem Cell Transplantation
- Sepsis Diagnosis and Treatment
Charles Darwin University
2019-2024
Menzies School of Health Research
2019-2024
Royal Darwin Hospital
2019-2024
Flinders University
2019-2024
Flinders Medical Centre
2023
Government of Western Australia Department of Health
2021
Royal Adelaide Hospital
2009
Snakebite-associated thrombotic microangiopathy (TMA) occurs in a subset of patients with venom-induced consumption coagulopathy (VICC) following snakebite. Acute kidney injury (AKI) is the commonest end-organ manifestation TMA. The epidemiology, diagnostic features, outcomes, and effectiveness interventions including therapeutic plasma-exchange (TPE), snakebite-associated TMA are poorly understood.We reviewed all suspected or confirmed snakebite recruited to Australian Snakebite Project...
To assess the accuracy and marginal value of quantitative D-dimer testing for diagnosing venom-induced consumption coagulopathy (VICC) in people bitten by Australian snakes.Analysis data suspected confirmed cases snakebite collected prospectively Snakebite Project, 2005-2019, from 200 hospitals across Australia.1363 patients whom was quantitatively assessed within 24 hours or snakebite.Diagnostic performance detecting systemic envenoming with VICC (area under receiver operating...
Thrombotic microangiopathy is an uncommon complication of snake envenoming associated with a subset snakebite cases presenting venom-induced consumption coagulopathy. It presents microangiopathic haemolytic anaemia and thrombocytopenia. Available studies are predominantly small retrospective observational only. Renal end organ injury appears common. has variably been likened to either thrombotic thrombocytopenic purpura or atypical uraemic syndrome. Many report acute kidney injury, dialysis...
Schistocytosis is the morphological hallmark of microangiopathic haemolytic anaemia thrombotic microangiopathy (TMA). Consensus guidelines for manual schistocyte quantitation are available, but limited research has evaluated them. The 2012 International Council Standardization in Haematology (ICSH) recommends a 1% as robust cut-off significance, with including helmet, crescent, triangle and keratocyte poikilocytes; microspherocytes only presence helmets, crescents/triangles, keratocytes. We...
The major systemic manifestation of hemotoxicity in human snakebite envenoming is venom-induced consumption coagulopathy (VICC). A subset patients with VICC develop thrombotic microangiopathy (TMA), which acute kidney injury (AKI) occurs. We aimed to investigate the association between schistocytosis and AKI, compared non-envenomed patients.Serial blood films collected from a prospective cohort (Australian Snakebite Project) were examined. Cases classified priori as snakebites (normal...
The Northern Territory (NT) is characterised by major health inequalities. A high proportion of the population Indigenous, with poor socioeconomic conditions and a burden disease. small NT - 1% total Australian dispersed over one-sixth Australia's land mass. Given this very low density geographical isolation many communities, access to services often difficult. Medical workforce recruitment retention have been persistent problems. Prior 2011, residents who aspired study medicine had leave...
Red cell (RC) alloantibodies occur on exposure to non-self RC antigens in transfusion and pregnancy (typically IgG clinically significant) or association with non-RC immune environmental factors IgM not significant). In Australia, the risk of alloimmunisation First Nations peoples is unknown. We assessed epidemiology, specificity, antecedents via a data linkage retrospective cohort study Northern Territory (NT) intensive care unit (ICU) patients (2015–2019). Of 4183 total patients, 50.9%...
Limited evidence exists on the distribution of ABO RhD blood groups and prevalence specificity red cell (RBC) alloantibodies in Aboriginal Torres Strait Islander peoples Australia. We investigated RBC alloantibody patients undergoing cardiac surgery at a South Australian (SA) tertiary hospital, major surgical referral centre for Northern Territory (NT) METHODS: Retrospective analysis all consecutive Flinders Medical Centre (FMC) between January 2014 June 2019. groups, prevalence,...
Background and Objective: Limited evidence exists on the distribution of ABO RhD blood groups less prevalence specificity red cell (RC) alloantibodies in Aboriginal Torres Strait Islander peoples Australia. The study aimed to determine RC patients undergoing cardiac surgery at a South Australian tertiary hospital.Materials Methods: Retrospective analysis group alloantibody data time until 2021 for all consecutive Flinders Medical Centre (FMC) between January 2014 June 2019. Incidence,...
The Northern Territory of Australia has a high proportion First Nations peoples living in remote communities and burden chronic autoimmune diseases. epidemiology clinical outcomes antiphospholipid syndrome (APS) Australians are poorly characterized.