A5072743983- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Congenital heart defects research
- Cardiac electrophysiology and arrhythmias
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Parasites and Host Interactions
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Silicon Carbide Semiconductor Technologies
- Nonlinear Dynamics and Pattern Formation
- Parasite Biology and Host Interactions
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Muscle activation and electromyography studies
- Eosinophilic Disorders and Syndromes
- Chromosomal and Genetic Variations
University of Aberdeen
2017-2020
Longwood University
2017
Drexel University
2010
UCLA Health
2006-2008
A.T. Still University
2002
Repolarization alternans is a harbinger of sudden cardiac death, particularly when it becomes spatially discordant. Alternans, beat-to-beat alternation in the action potential duration (APD) and intracellular Ca (Cai), can arise from either tissue heterogeneities or dynamic factors. Distinguishing between these mechanisms normal difficult because inherent complex three-dimensional heterogeneities. To evaluate repolarization simpler two-dimensional substrate, we optically recorded voltage...
Summary Adoptive transfer of T cells is a promising cancer therapy and expression chimeric antigen receptors can enhance tumour recognition T‐cell effector functions. The programmed death protein 1 ( PD 1) receptor prospective target for because ligands are expressed on many types, including lymphoma. Therefore, we developed murine (ch consisting the extracellular domain fused to cytoplasmic CD 3ζ. Additionally, therapies use various co‐stimulatory domains efficacy. Hence, inclusion Dap10 or...
The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA genome-wide transcriptomics analysis. gata4 particularly interesting because GATA4 is able to induce beating cardiomyocytes Xenopus mammalian systems. Among the gata4-regulated transcripts we two SoxF family members, sox7 sox18. Experimental...
Cancer cluster investigations rarely receive significant public health resource allocations due to numerous inherent challenges and the limited success of past efforts. In 2008, a polycythemia vera, rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A multidisciplinary group federal state agencies, academic institutions, local healthcare providers subsequently developed multifaceted research portfolio designed better understand cause cluster. This agenda...
The transcription factors GATA4, GATA5 and GATA6 play important roles in heart muscle differentiation. data presented this article are related to the research entitled "Genome-wide transcriptomics analysis identifies sox7 sox18 as specifically regulated by gata4 cardiomyogenesis" (Afouda et al., 2017) [1]. present study genes these individual cardiogenic GATA using genome-wide analysis. We have that each of them, well those either them. gene ontology terms (GO) associated with differentially...
The support of skeletal muscle work is critically dependent upon the precise matching convective oxygen delivery (QO2) and consumption (VO2). Controversy exists whether QO2 or VO2 constitute a limiting factor in transition from rest to work. Skeletal microvascular PO2 (PO2m) reflects dynamic balance between VO2. At onset contractions, there characteristic time delay (TD) 12–20 s before PO2m changes. We reasoned that if this TD due relatively slower increase oxidative metabolism (metabolic...