A5064978943- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Essential Oils and Antimicrobial Activity
- Trypanosoma species research and implications
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Phytochemistry and Biological Activities
- Chemical Synthesis and Reactions
- Natural product bioactivities and synthesis
- Click Chemistry and Applications
- Fluorine in Organic Chemistry
- Botany, Ecology, and Taxonomy Studies
- Agricultural and Food Sciences
- Synthesis and Reactivity of Heterocycles
- Inflammatory mediators and NSAID effects
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Synthesis of heterocyclic compounds
- Catalysis and Oxidation Reactions
- Food Science and Nutritional Studies
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Traditional and Medicinal Uses of Annonaceae
Universidade Estadual de Maringá
2017-2024
Universidade Estadual do Centro-Oeste
2015-2020
An alternative highly regioselective synthetic method for the preparation of 3,5-disubstituted 4-formyl-N-arylpyrazoles in a one-pot procedure is reported. The methodology developed was based on regiochemical control cyclocondensation reaction β-enamino diketones with arylhydrazines. Structural modifications diketone system allied to Lewis acid carbonyl activator BF3 were strategically employed this control. Also 4-hydroxymethyl-N-arylpyrazole derivatives from and arylhydrazine substrates described.
A simple and efficient methodology for highly regioselective synthesis of azomethine pyrazoles isoxazoles containing a trifluoromethyl group is reported. The cyclocondensation trifluoromethylated β-enamino diketones (TBED) with phenylhydrazine hydroxylamine hydrochloride, in the presence BF3, provided 5-aryl-4-[(tert-butyl)iminomethyl]-3-trifluoromethylazoles by aza-Michael-type 1,2-addition. scope reaction was expanded transimination arylamines one-pot method starting from TBED. Thus, 83...
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated isothiosemicarbazone and 2-amino-1,3,4-thiadiazole hybrids were synthesised evaluated in vitro against the promastigote form Leishmania amazonensis epimastigote Trypanosoma cruzi, pathogens causing neglected tropical diseases leishmaniasis Chagas disease, respectively. The results show potential these compounds regarding their antiparasitic properties. Studies on structure-activity relationship demonstrated that...
The new pyrido[2,3- d ]pyridazine-2,8-dione 7c showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.
A simple, efficient and highly regioselective method for the preparation of 3,4- 4,5-disubstituted N-methylpyrazoles in a one-pot procedure is reported. The methodology developed was based on regiochemical control reaction 4-acyl-1H-pyrrole-2,3-diones methylhydrazine with an influence addition or absence acid substrate structure.
An efficient and controlled site-selective annulation of 3,5-diethoxycarbonyl 4-hydrazonyl pyrazoles is described. The relative proportion the products affected by hydrazone intermediate configuration, reaction temperature, Lewis acid employed. At a temperature 110-120 °C, preferentially afforded 1H-pyrazolo[3,4-d]pyridazin-7(6H)-ones, whereas using Yb(OTf)3 in MeCN reflux, 2H-pyrazolo[3,4-d]pyridazin-7(6H)-ones were favored. Computational investigations performed to clarify mechanism origin...
Natural extracts present antioxidant activity and can replace synthetic antioxidants. This study aimed to extract essential oil from Pitanga (Eugenia uniflora L.) leaves evaluate its chemical composition, as well antibacterial activities. The was obtained by hydrodistillation for 3 hours with a yield of 1.34 ± 0.18 %. total evaluated the DPPH phosphomolybdenum methods. presented an IC50 value 100.96 µL mL‑1 1503.44 29.48 mg α‑tocopherol mL-1 oil. major compounds identified GC-MS were...
Verbena minutiflora (Verbenaceae) is popularly consumed as an infusion for the treatment of various diseases. However, so far there no pharmacological or chemical validation to support its therapeutic applications. Therefore, analysis composition and activities V. crucial. In this study, extracts infusions aerial parts (leaves, flowers stems) were analyzed during four consecutive years. Extracts leaves had significantly higher phenolic content antiradical capacity than stems regardless year...
Resumo: Algumas espécies de plantas do gênero Bauhinia são medicinais com relevantes propriedades diuréticas, digestivas, anti-inflamatórias, analgésicas, sendo popularmente usadas no tratamento da hipertensão e diabetes.As deste conhecidas como "pata-de-vaca" devido ao formato suas folhas; essa similaridade morfológica entre e/ou subespécies torna sua diferenciação taxonômica um desafio.Buscando uma ferramenta auxiliar para discriminar Bauhinia, as impressões digitais espectroscópicas...
A series of 60 4-aminomethyl 5-aryl-3-substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis Chagas disease, respectively. Thirteen compounds exhibited a selective index greater than 10. The 3-N-acylhydrazone isoxazole derivatives bearing bithiophene core best antiparasitic effects.
Herein we report for the first time levels of phenylpropanoids and iridoids in extracts infusions V. minutiflora consumed Brazil to treat urinary infectious disorders. An house validation study demonstrated good accuracy precision determine bioactive compounds by HPLC-DAD. Phenylpropanoids varied (leaves 139.70 221.20 mg g-1, flowers 106.43 227.22 stems 42.18 56.48 g-1). Verbascoside occurred higher concentration leaves (87.66 - 136.16) g-1 (58.12 148.96) than (19.24 24.62) g-1. Iridoids...
Invited for this month's cover picture is the group of Prof. Fernanda Andreia Rosa at State University Maringá (Brazil). The shows contribution SINTHET research to synthesis and discovery new antiprotozoal compounds. synthetic methodology allowed construction 60 isoxazole derivatives with structural variations on 3-, 4-, 5-positions. authors acknowledge Ms. Jeniffer do Nascimento Ascencio Camargo Julia Caroline Manzano Willig Cover creation. Read full text their Full Paper 10.1002/open.202100141.
Medicinal herbs move about US$ 22 billion a year worldwide.In chamomile we can find cyclic sesquiterpenoids as alpha-bisabolol, the farnesene, chamazulene, and matricina.As approximately 50-65% of total composition oil consist in farnesenes Bisabolol type molecules.Considering value chamomile's essential oils components, this study aimed to evaluate how different types sterilization, which are autoclaving, microwave ultraviolet, interfere with composition.Our results allow us conclude that...