A5026640568- Malaria Research and Control
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- Coccidia and coccidiosis research
- Helminth infection and control
- Complement system in diseases
- Drug Transport and Resistance Mechanisms
University of Basel
2017-2021
Swiss Tropical and Public Health Institute
2017-2021
Radboud University Nijmegen
2020
Bernhard Nocht Institute for Tropical Medicine
2020
Radboud University Medical Center
2020
University Medical Center
2020
Transmission represents a population bottleneck in the Plasmodium life cycle and key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective mosquito vector. Gametocyte production rates vary depending on environmental conditions, but external stimuli remain obscure. Here, we show that host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by...
Our current understanding of mitochondrial functioning is largely restricted to traditional model organisms, which only represent a fraction eukaryotic diversity. The unusual mitochondrion malaria parasites validated drug target but remains poorly understood. Here, we apply complexome profiling map the inventory protein complexes across pathogenic asexual blood stages and transmissible gametocyte Plasmodium falciparum. We identify remarkably divergent composition clade-specific additions all...
Abstract The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion parasites commits to sexual development and differentiates into gametocytes, which are essential for transmission via mosquito vector. Detailed molecular investigation gametocyte biology has been hampered by difficulties generating large numbers these highly specialised cells. Here, we engineer P. NF54 inducible producer (iGP)...
Fascioliasis is a zoonotic infection of humans and, more commonly, ruminants. It caused by 2 liver fluke species, Fasciola hepatica and gigantica, which differ in size. The traditional morphological methods used to distinguish the species can be unreliable, particularly presence hybrids between species. development advanced molecular has allowed for definitive identification including their hybrids. Hybrids are concern, as it thought that they could acquire advantageous traits such increased...
Abstract The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion parasites commits to sexual development and differentiates into gametocytes, which are essential for transmission other human hosts via mosquito vector. Detailed molecular investigation gametocyte biology has been hampered by difficulties generating large numbers these highly specialized cells. Here, we engineered marker-free P....
Abstract Our current understanding of mitochondrial functioning is largely restricted to traditional model organisms, which only represent a fraction eukaryotic diversity. The unusual mitochondrion malaria parasites validated drug target but remains poorly understood. Here, we apply complexome profiling map the inventory protein complexes across pathogenic asexual blood stages and transmissible gametocyte Plasmodium falciparum . We identify remarkably divergent composition clade-specific...
Abstract The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion parasites commits to sexual development and differentiates into gametocytes, which are essential for transmission other human hosts via mosquito vector. Detailed molecular investigation gametocyte biology has been hampered by difficulties generating large numbers these highly specialized cells. Here, we engineered marker-free P....