A5086674513- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Posttraumatic Stress Disorder Research
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Memory Processes and Influences
- Hormonal Regulation and Hypertension
- Child Abuse and Trauma
- Cardiac Arrest and Resuscitation
- Identity, Memory, and Therapy
- Olfactory and Sensory Function Studies
- Child and Adolescent Psychosocial and Emotional Development
- Early Childhood Education and Development
- Biochemical effects in animals
- Cardiac Health and Mental Health
- Human Health and Disease
- Diverse academic research themes
- Alkaloids: synthesis and pharmacology
- Ferroelectric and Negative Capacitance Devices
- Menstrual Health and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Creativity in Education and Neuroscience
- Psychedelics and Drug Studies
Ohio Northern University
2015-2024
University of South Florida
2006-2008
AdventHealth Tampa
2008
Wheeling Jesuit University
2003
We have studied the effects of an acute predator stress experience on spatial learning and memory in adult male female Sprague-Dawley rats. All rats were trained to learn location a hidden escape platform radial-arm water maze (RAWM), hippocampus-dependent task. In control (non-stress) condition, superior males accuracy consistency their performance tested over multiple days training. exposed cat for 30 min immediately before or after learning, 24-h test. Predator dramatically increased...
People who are exposed to horrific, life-threatening experiences at risk for developing post-traumatic stress disorder (PTSD). Some of the symptoms PTSD include persistent anxiety, exaggerated startle, cognitive impairments and increased sensitivity yohimbine, an α2-adrenergic receptor antagonist. We have taken into account conditions known induce PTSD, as well factors responsible long-term maintenance disorder, develop animal model PTSD. Adult male Sprague–Dawley rats were administered a...
Abstract We have studied the effects of spatial learning and predator stress‐induced amnesia on expression calcium/calmodulin‐dependent protein kinase II (CaMKII), brain‐derived neurotrophic factor (BDNF) calcineurin in hippocampus, basolateral amygdala (BLA), medial prefrontal cortex (mPFC). Adult male rats were given a single training session radial‐arm water maze (RAWM) composed 12 trials followed by 30‐min delay period, during which either returned to their home cages or inescapable...
Agomelatine, a novel antidepressant with established clinical efficacy, acts as melatonin receptor agonist and 5-HT2C antagonist. As stress is significant risk factor in the development of depression, we sought to determine if chronic agomelatine treatment would block stress-induced impairment memory rats trained radial-arm water maze (RAWM), hippocampus-dependent spatial task. Moreover, since neural cell adhesion molecule (NCAM) known be critically involved consolidation synaptic...
We have studied the influence of pre-training psychological stress on expression c-fos mRNA following long-term spatial memory retrieval. Rats were trained to learn location a hidden escape platform in radial-arm water maze, and then their for was assessed 24 h later. Rat brains extracted 30 min after 24-h test trial analysis mRNA. Four groups tested: (1) given standard training (Standard); (2) cat exposure (Predator Stress) prior (Pre-Training Stress); (3) only (Water Yoked); (4) no (Home...
The development of effective pharmacotherapy for major depression is important because it such a widespread and debilitating mental disorder. Here, we have reviewed preclinical clinical studies on tianeptine, an atypical antidepressant which ameliorates the adverse effects stress brain memory. In animal studies, tianeptine has been shown to prevent stress-induced morphological sequelae in hippocampus amygdala, as well from impairing synaptic plasticity prefrontal cortex hippocampus....
Over a century of behavioral research has shown that stress can enhance or impair learning and memory. In the present review, we have explored complex effects on cognition propose they are characterized by linear non-linear dose-response functions, which together reveal hormetic relationship between learning. We suggest initially enhances hippocampal function, resulting from amygdala-induced excitation synaptic plasticity, as well excitatory several neuromodulators, including...
Childhood maltreatment may alter fear neurocircuitry, which results in pathological anxiety and depression. One alteration of fear-related behaviors that has been observed several psychiatric populations is an overgeneralization fear. Thus, we examined the association between childhood generalization a non-clinical sample young adults. Two hundred ninety-one participants underwent differential conditioning fear-potentiated startle paradigm. visual stimulus (CS+), but not another (CS-), was...
Individuals with post-traumatic stress disorder (PTSD) experience many debilitating symptoms, including intrusive memories, persistent anxiety and avoidance of trauma-related cues. PTSD also results in numerous physiological complications, increased risk for cardiovascular disease (CVD). However, characterization PTSD-induced alterations is lacking, especially preclinical models the disorder. Thus, we examined impact a psychosocial predator-based animal model on myocardial sensitivity to...