A5054709008- Sleep and Wakefulness Research
- Antibiotics Pharmacokinetics and Efficacy
- Zebrafish Biomedical Research Applications
- Pneumonia and Respiratory Infections
- Tryptophan and brain disorders
- Sleep and related disorders
- Anesthesia and Pain Management
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Circadian rhythm and melatonin
- Sphingolipid Metabolism and Signaling
- Heart Failure Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Bacterial Infections and Vaccines
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Cardiac pacing and defibrillation studies
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- Exercise and Physiological Responses
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Antibiotic Resistance in Bacteria
- Advanced Drug Delivery Systems
University of Helsinki
1988-2025
Orion Corporation (Finland)
1988-2023
Finnish Institute for Health and Welfare
2011-2015
National Institutes of Health
2013
Public Health Institute
1996
Similarity between influenza nucleoprotein and hypocretin receptor 2 may trigger vaccine-associated narcolepsy.
The emergence of resistant pneumococci makes the treatment pneumococcal diseases difficult. currently available polysaccharide vaccines have very limited efficacy in young children. immunogenicity can be improved by covalent coupling to protein carriers as has been shown with Haemophilus influenzae type b.Thirty healthy infants were immunized a conjugate vaccine at 2, 4 and 6 months age. Oligosaccharides derived from capsular polysaccharides types 6B, 14, 18C, 19F 23F conjugated nontoxic...
Background Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood. Vaccine-attributable risk narcolepsy reported so far with AS03 adjuvanted H1N1 vaccination Pandemrix has been manifold compared to Arepanrix, which contained differently produced viral antigen preparation. Hence, antigenic differences antibody response these vaccines were investigated. Methods Findings Increased...
Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data available on fungal in the children at risk type 1 diabetes (T1D). We hypothesized that co-occurrence and contributes to intestinal inflammation autoimmune destruction insulin-producing beta-cells T1D. Fecal blood samples were collected from 26 tested positive for least one diabetes-associated autoantibody (IAA, GADA, IA-2A or ICA) matched autoantibody-negative with HLA-conferred susceptibility...
Abstract Narcolepsy type 1 (NT1) is a chronic neurological disorder having strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among children or adolescents vaccinated AS03 adjuvant-supplemented pandemic H1N1 influenza A vaccine, Pandemrix. Here we show that pediatric Pandemrix-associated patients have enhanced T-cell immunity against the viral epitopes, neuraminidase 175–189 (NA ) and nucleoprotein 214–228 (NP ), but...
<title>Abstract</title> The appearance of diabetes-associated autoantibodies is the first detectable sign disease process leading to type 1 diabetes (T1D). Evidence suggests that T1D a heterogenous disease, where antibodies formed imply subtypes. Here, we followed 49 children, who subsequently presented with and matched controls, profiling single-cell epigenomics at different time points development. Quantitation cell nuclei populations as well transcriptome open-chromatin states indicated...
Background Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02. A sudden increase in the incidence of childhood narcolepsy was observed after vaccination AS03-adjuvanted Pandemrix influenza vaccine Finland at beginning 2010. Here, we analysed whether coinciding H1N1pdm pandemic contributed, together vaccination, to increased The analysis based on presence or absence...
Exercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects molecular pathways associated with immune function, especially in overweight individuals. However, prolonged intense exercise training periods without sufficient recovery energy intake aiming to accomplish very low levels of body fat may lead temporary immunodepression. Here, we applied high-throughput systems biology approach better characterize potential key system modulation...
ABSTRACT The production of bacteriocin-like inhibitory substances, mutacins, by mutans streptococci varies among isolates. To find if the degree mutacin activity an isolate was related to its transmission between mother and her child, 19 mothers their 18-month- 3-year-old children were sampled for oral streptococci. In addition, stability studied with isolates from five unrelated 5-year-old in 5- 7-year follow-up studies. A total 145 streptococcal serotyped immunodiffusion, ribotyped, typed...
Several lines of research support immune system dysregulation in psychotic disorders. However, it remains unclear whether the immunological marker alterations are stable and how they associate with brain glial cell function. This longitudinal study aimed at investigating peripheral functions altered early phases disorders, changes associated core symptoms, remission, function, persist a one-year follow-up. Two independent cohorts comprising total 129 first-episode psychosis (FEP) patients...
Levosimendan (LS), a Ca<sup>2+</sup> sensitizer, is presently limited to i.v. administration. The dose-related pharmacodynamic effects of newly developed oral LS remain undetermined. We assessed the dose-response relationship in nine normal and seven pacing-induced heart failure (HF), conscious, chronically instrumented mongrel dogs. Animals received placebo capsule on day 1, then was administered at single doses 0.025 (day 2), 0.05 4), 0.1 8) mg/kg. serially measured plasma concentrations,...
Absorption of erythromycin acistrate (EA) and two base (EB) preparations (enterotablet A B) taken after an overnight fast or immediately before a standard breakfast was studied in 29 healthy volunteers three separate studies, cross-over, randomized design. In Study I, the absorption single dose (400 mg) EA similar fasting non-fasting state. There was, however, more interindividual variation subjects markedly impaired presence food. Cimetidine given at doses + 800 had no effect on...
The kinetics of erythromycin acistrate (EA). a new ester prodrug erythromycin, were studied in three comparative, randomized, cross-over studies 29 healthy volunteers. A mass-spectrometric method was used to assay separately 2′-acetyl and their anhydro (spiroketal) forms. In Part I, the total antibiotic concentration higher after EA than stearate (ES; 1.8-fold) enterocoated pellets base (EB, enterocapsules; 1.4-fold). plasma, however, only about one third hydrolysed active erythromycin....
Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence of childhood adolescent narcolepsy was observed after a vaccination campaign AS03-adjuvanted Pandemrix influenza vaccine Nordic several other countries 2010 2011. Previously, it has been suggested that surface-exposed region nucleoprotein, structural...
The drug concentration in plasma, suction skin blister fluid (SBF), urine and saliva after repeated dosage of either erythromycin acistrate (EA) or enterocoated pellets base (EB) was studied young healthy volunteers with a cross-over design two separate studies. In Study I, the total (erythromycin +2′-acetyl erythromycin) EA (400 mg tid) slightly higher than EB (500 tid). about half that EB. SBF antibiotic were 49 46% corresponding plasma concentrations, respectively. degree hydrolysis...
Abstract Objective To study the safety and effectiveness of consecutively administered ropinirole apomorphine (both dopamine 2‐like receptor agonists) for emesis induction in dogs. Design Prospective, crossover design. Setting Institutional animal research facility. Animals Six healthy male purpose‐bred Beagle Interventions Each dog received 4 treatments: (1) infusion (21 μg/kg) over 30 minutes + eye drops (3.75 mg/m 2 ); (2) (108 μg/m ) SC (100 μg/kg); (3) (7.5 after minutes; (4) minutes....
The efficacy of erythromycin stearate (ES) and its 2'-acetyl ester (erythromycin acistrate, EA) was compared in eight experimental infections mice both sexes. In two studies the were made leukopenic by whole-body irradiation. Four absorption also performed parallel. Streptococcus pneumoniae peritonitis, protective dose 50% (PD50) value EA ES, given s.c., did not differ from each other. bioavailability slightly inferior to that ES. three other peritonitis (2 Staphylococci 1 Streptococcus),...