Xiaokun Yan

ORCID: 0000-0001-9998-3331
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Phytase and its Applications
  • Chronic Disease Management Strategies
  • Frailty in Older Adults
  • Rock Mechanics and Modeling
  • Geotechnical Engineering and Analysis
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Soybean genetics and cultivation
  • Cassava research and cyanide
  • Geotechnical Engineering and Underground Structures
  • Tunneling and Rock Mechanics
  • Infrastructure Maintenance and Monitoring
  • Liver Disease Diagnosis and Treatment
  • RNA modifications and cancer
  • Eosinophilic Esophagitis
  • 3D Surveying and Cultural Heritage
  • Alcohol Consumption and Health Effects
  • Epigenetics and DNA Methylation
  • Nutritional Studies and Diet
  • Food composition and properties
  • Cancer-related gene regulation
  • Plant Micronutrient Interactions and Effects
  • Asthma and respiratory diseases
  • Image and Object Detection Techniques
  • Protein Hydrolysis and Bioactive Peptides
  • Chronic Obstructive Pulmonary Disease (COPD) Research

Suzhou Traditional Chinese Medicine Hospital
2017-2025

Harbin Institute of Technology
2024

Nanjing Agricultural University
2015-2017

Observational studies have underscored a robust association between frailty and chronic obstructive pulmonary disease (COPD), yet the causality remains equivocal. This study employed bidirectional two-sample Mendelian randomization (MR) analysis. Univariable MR investigated causal relationship COPD. Genetic correlation was assessed using linkage disequilibrium score (LDSC) regression. Multivariable mediation analysis explored influence of various confounders their mediating effects. The...

10.2147/copd.s501635 article EN cc-by-nc International Journal of COPD 2025-01-01

Abstract Lung cancer, especially non-small-cell lung cancer (NSCLC), has a poor 5-year survival rate below 20%, with factors like smoking, air pollution, and genetic mutations contributing to its development. ABI3BP, an extracellular matrix protein, inhibits NSCLC progression by regulating key signaling pathways; however, exact mechanisms remain elusive. This study aimed explore ABI3BP’s role in impact on these pathways. We found that ABI3BP expression was significantly reduced cells...

10.1515/biol-2022-1034 article EN cc-by-nc-nd Open Life Sciences 2025-01-01

Summary In this study, effects of two organic acids spraying on the growth profiles, phytic acid content, antioxidant capacity, phytase activity and related genes expression during mung bean germination were investigated. Results showed that both oxalic malic effective ways to improve degradation by inducing expression, but no significant difference was found in content between treatments. The contents total phenolics MDA (malondialdehyde) higher, whereas ascorbic sprout length higher. Both...

10.1111/ijfs.12941 article EN International Journal of Food Science & Technology 2015-09-07

In this study, the effects of NaCl, CaCl2 and NaCl-CaCl2 treatments on growth profiles, nutritional quality, phytic acid degradation-lower inositol phosphate formation system germinated mung bean were investigated. Mung seeds at 30 oC in darkness for 4 days sprayed solutions containing distilled water, 1.6 mM 6 CaCl2, NaCl plus every 1 h . Samples collected 2 liquid nitrogen experiments each experiment was repeated three times. The results showed that treatment improved quality significantly...

10.9755/ejfa.2016-06-758 article EN cc-by Emirates Journal of Food and Agriculture 2017-01-01

It is still a challenge to accurately evaluate the structural safety of tunnel during process construction. To address this issue, evaluation approach based on monitoring data construction proposed in study. Firstly, detailed description modelling excavation, releasing load acting tunnel, and selecting constitutive relationship surrounding rock introduced. Secondly, aiming at an actual shallow‐buried with underground utilizing analytical results deformation evaluated by using...

10.1155/2021/6680675 article EN cc-by Shock and Vibration 2021-01-01

This study was conducted to compare the perioperative outcomes of two-portal and three-port video-assist thoracoscopic surgery (VATS) for early stage nonsmall cell lung cancer. In this retrospective analysis, 279 cases two-port VATS with a single utility port 152 performed by our department from October 2010 December 2014 were collected. The operative time, volume intraoperative blood loss, number dissected lymph nodes, postoperative pleural drainage, extubation duration hospitalization...

10.1097/md.0000000000007796 article EN cc-by-nc Medicine 2017-08-01

The uncertainty of surrounding rock parameters varies due to changes in the boundary conditions tunnel model, and no suitable method ensure that updated finite element model (FEM) are applicable throughout constructional environment. To address this issue, a probabilistic baseline was introduced invert obtain values for complete First, statistical theory applied statistically analyze measurement data from tunnels under different environments, which provides insight into variation parameters....

10.3390/geosciences14040107 article EN cc-by Geosciences 2024-04-19

<title>Abstract</title> <bold>Background:</bold> Serum urate levels have been associated with a lower risk of lung carcinogenesis in observational studies but the causality from serum on cancer has yet to determined. We conducted bidirectional Mendelian randomization(MR) study evaluate causal effect these associations. <bold>Methods:</bold> Summary-level data for were obtained 288,649 CKDGen participants European ancestry. drew summary statistics TRICL (29,266 cases and 56,450 controls),...

10.21203/rs.3.rs-4407411/v1 preprint EN cc-by Research Square (Research Square) 2024-05-30

<title>Abstract</title> <bold>Background</bold> Observational studies have underscored a robust association between frailty and chronic obstructive pulmonary disease (COPD), yet the causality remains equivocal.<bold>Methods</bold> This study employed bidirectional two-sample Mendelian randomization (MR) analysis. Individuals of European ancestry with COPD were selected for analysis under genome-wide significance threshold (<italic>P</italic> &lt; 5×10–8). Univariable MR investigated causal...

10.21203/rs.3.rs-4869762/v1 preprint EN cc-by Research Square (Research Square) 2024-08-28
Coming Soon ...