A5075692051- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Proteoglycans and glycosaminoglycans research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- RNA Research and Splicing
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Smoking Behavior and Cessation
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
Mashhad University of Medical Sciences
2015-2024
Ferdowsi University of Mashhad
2024
Academic Center for Education, Culture and Research
2024
Pancreatic cancer (PC), as one of the main endocrine and digestive systems malignancies has highest related mortality in world. Lack evident clinical symptoms appropriate diagnostic markers early stages tumor progression are reasons high rate among PC patients. Therefore, it is necessary to investigate molecular pathways involved progression, order introduce novel methods. Epithelial mesenchymal transition (EMT) a critical cellular process associated with pancreatic cells invasion distant...
Background: Colorectal cancer (CRC) is a highly widespread malignancy and ranks as the second most common cause of cancer-related mortality. Objective: Cancer patients, including those with CRC, who undergo chemotherapy, are often treated platinum- based anticancer drugs such oxaliplatin (OXA). Nevertheless, administration OXA associated range gastrointestinal problems, neuropathy, respiratory tract infections. Hence, it necessary to devise potential strategy that can effectively tackle...
Abstract The lymphatic system, crucial for tissue fluid balance and immune surveillance, can be severely impacted by disorders that hinder its activities. Lymphatic malformations (LMs) are caused accumulation in tissues owing to defects channel formation, the obstruction of vessels or injury tissues. Somatic mutations, varying symptoms based on lesions' location size, provide insights into their molecular pathogenesis identifying LMs' genetic causes. In this review, we collected most recent...
Therapeutic vaccinations are designed to prevent cancer by inducing immune responses against tumor antigens. in cells, tumor-associated antigens (TAA) or tumor-specific (mutated) derived peptides presented within the clefts of main histocompatibility complex (MHC) class I II molecules, they either activate cytotoxic T-lymphocytes (CTLs), CD4
BACKGROUND: Matrix metalloproteinases (MMPs) can degrade essentially the extracellular matrix (ECM) components. MMPs are important regulators of tumor growth; hence enzymes considered as targets for cancer therapy. MMP-13 is specially activated in gastric and promotes i nvasiveness primary tumors. Helicobacter Pylori (H.pylori) interacts with epithelial cells stimulates it to produce vitro. OBJECTIVE: The relation between gene expression clinicopathological characteristics presence H.pylori...
Interaction between LINC-ROR and Stemness State in Gastric Cancer Cells with Helicobacter pylori Infection
Abstract Background MEIS1 (Myeloid ecotropic viral integration site 1), as a homeobox (HOX) transcription factor, has dual function in different types of cancer. Although numerous roles are proposed for differentiation, stem cell function, gastrointestinal development and tumorigenesis, the involved molecular mechanisms poor understood. Our aim this study was to elucidate functional correlation between , regulator differentiation process, genes human esophageal squamous carcinoma (ESC) line...
Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, stem cell maintenance, and tumor progression. It also participates multiple signaling pathways including Wnt, Notch, TGF-β. Remarkably, it expressed cancer (CSC) compartments, boosting migration, invasion, angiogenesis. Although Cripto-1 overexpressed variety human malignant tumors, its expression esophageal squamous carcinoma (ESCC) remains unclear. Our aim this study was to evaluate possible oncogenic...
Objective: CD44 is an important cell adhesion molecule that plays a key role in growth, invasion, proliferation and metastasis of cancer cells. protein over-expression associated with poor prognosis gastric (GC) previous studies have shown gene polymorphisms could affect survival recurrence. In this study, we tested the hypothesis impacting on signaling pathway may predict clinical outcomes patients GC. Materials Methods: DNA was extracted from blood 150 healthy individuals formalin-fixed...