A5031193069- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Sexual Differentiation and Disorders
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Metabolism and Genetic Disorders
- Colorectal Cancer Screening and Detection
- Hormonal and reproductive studies
- Drug Transport and Resistance Mechanisms
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Immunotherapy and Biomarkers
- Autism Spectrum Disorder Research
- Circular RNAs in diseases
- CAR-T cell therapy research
Mashhad University of Medical Sciences
2015-2024
Birjand University of Medical Sciences
2022
NourDanesh Institute of Higher Education
2017
Danesh-e-Tandorosti Iranian Institute of Higher Health
2017
Imam Reza Hospital
2016
Ghaem Hospital
2011
Institute of Human Genetics
2009
Iranian Academy of Medical Sciences
2006
Georgetown University
1997-2000
Georgetown University Medical Center
1997-2000
Colon adenocarcinoma (COAD) is one of the most common gastrointestinal cancers globally. Molecular aberrations tumor suppressors and/or oncogenes are main contributors to tumorigenesis. However, exact underlying mechanisms COAD pathogenesis clearly not known yet. In this regard, there an urgent need indicate promising potential diagnostic and prognostic biomarkers in patients.In current study, level 3 RNA-Seq miR-Seq data corresponding clinical colon were retrieved from TCGA database. The...
AIM:To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, correlation with clinical histological features. M E T H O D S :S a m p l e s w r o b t i n d f 5 2 histologically confirmed cases of adenocarcinoma.Gastric 50 age-and sex-matched individuals normal gastroscopy biopsy were obtained as control samples.Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status promoter.p16-protein...
Abstract Background Tumor suppressor genes p53 and p16 INK4a the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory whose loss of function is associated with ESCC carcinogenesis. We assessed aberrant methylation gene its impact on protein expression correlations expressions in patients Golestan province northeastern Iran which has highest incidence cancer, well above world average. Methods Cancerous tissues adjacent normal tissue obtained from 50 were...
Gastric cancer (GC) is regarded as the fifth most common and third cause of cancer-related deaths worldwide.Mechanism GC pathogenesis still unclear relies on multiple factors, including environmental genetic characteristics.One important factors occurrence infection with Helicobacter pylori that classified class one carcinogens.Dysregulation several genes pathways play an essential role during gastric carcinogenesis.Dysregulation developmental such Wnt/β-catenin signaling, Hedgehog Hippo...
Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background early embryogenesis. Approximately 15 to 20% all pregnancies humans are terminated as recurrent spontaneous abortions (RSAs). The aim this was detect chromosome abnormalities couples with RSAs and compare our results those reported previously.In retrospective study, pattern chromosomal aberrations evaluated during a six-year period from 2005 2011. population under 728 who attended...
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with high phenotypic and genetic heterogeneity, complicating the discovery causative genes. Through forward genetics approach selecting for defective vocalization in mice, we identified Kdm5a as candidate ASD gene. To validate our discovery, generated knockout mouse model ( -/- ) confirmed that inactivating disrupts vocalization. In addition, mice displayed repetitive behaviors, sociability deficits, cognitive...
ABSTRACT The city of Mashhad is the capital Khorasan, northeastern province Iran, which has been recognized as an area where human T-lymphotropic virus type 1 (HTLV-1) infection endemic. All serum samples from blood donors are routinely screened for HTLV-1 by using enzyme-linked immunosorbent assay (ELISA). In present study, 28,926 (81.86% male and 18.14% female) with a mean age 32 years (range, 18 to 65 years) were in 6 months period (July December 1999). Of these primary screening, 228...
Cancer-testis antigens (CTAs) are often specifically expressed in cancer cells and under normal conditions only considered to be the germ line placenta. CTAs potential targets for immunotherapy therefore necessitates their expression profiling. The profile of LAGE1, MAGE-A4 NY-ESO1, possible correlations interaction, clinicopathological associations each marker were studied. RNA was extracted from fresh esophagectomy tissues 41 esophageal squamous cell carcinoma (ESCC) patients prior any...
The relationship between depression and increased oxidative stress is well known. DNA damage by oxidation factors an important cause of the aging process in psychiatric disorders.Owing to scarcity human studies high inconsistencies effects antidepressants on damage, current study was undertaken investigate its treatment damage.In a 15-week open-label citalopram (n = 25) sertraline 20), levels were measured comet assay, proinflammatory (Interlukin-6 (IL-6)) (8-hydroxy-2'-deoxyguanosine...
Esophageal cancer is the sixth-leading cause of cancer-related deaths worldwide. Cancer stem cells (CSCs) are main reason for tumor relapse in esophageal squamous cell carcinoma (ESCC). The NOTCH pathway important preservation CSCs, therefore it possible to target such by targeting MAML1 as component transcription machinery.In present study we isolated CD44+ ESCC CSCs and designed a MAML1-targeted therapy inhibit signaling pathway. were using magnetic sorting utilizing CD44 surface marker....
Overexpression of MAGEA4 oncogene has been demonstrated in different malignancies; however, little is known about its exact mechanism for overexpression. TWIST1, as a bHLH transcription factor, activates cell migration-invasion program involved both embryonic and tumor development. Since overexpression was statistically correlated to we aimed elucidate the probable regulatory role TWIST1 on expression KYSE30 cells.Expression pattern analyzed 55 ESCC patients using relative comparative...
Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression metastasis. Although, there various reports about the prognostic value of EGFR separately gastric cancer, is not any report probable correlation between co-expression cancer prognosis. In present study, we assessed co-overexpression (in level mRNA protein expression) prognosis for first time.ErbB1 expressions were analyzed by immunohistochemistry real-time PCR 50 patients with cancer....