A5033507359- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacological Effects and Toxicity Studies
- Synthesis and biological activity
- Saffron Plant Research Studies
- Curcumin's Biomedical Applications
- Phytochemistry and Biological Activities
- Pregnancy and Medication Impact
- Neonatal Health and Biochemistry
- Hedgehog Signaling Pathway Studies
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Bioactive Compounds
- Phytochemical and Pharmacological Studies
- Erythrocyte Function and Pathophysiology
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Silymarin and Mushroom Poisoning
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Pain Mechanisms and Treatments
- Epilepsy research and treatment
- Pesticide Exposure and Toxicity
Mashhad University of Medical Sciences
2015-2024
Al-Zahraa University for Women
2020-2024
University of Karbala
2019-2024
Tehran University of Medical Sciences
2022
Ahl Al Bayt University
2017-2021
McGill University
1995-1998
Objective: Saffron Crocus sativus L. (Iridaceae) is known for anticancer properties. However, limited effort has been made to correlate these effects the active ingredients of saffron. In present study, cytotoxic crocin, major coloring compound in saffron, and its nanoliposomal form better cellular delivery are investigated.Methods: HeLa MCF-7 cells were cultured exposed crocin (1, 2, 4 mM) liposomal (0.5 1 mM). The 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay...
In this study, the anti-nociceptive and anti-inflammatory effects of cyanocobalamin (Vit B12) against acute chronic pain inflammation were evaluated in mice. Vit B12 (0.87, 1 1.77 mg/kg) injected intraperitoneally. The examined using hot-plate writhing tests. was 14 days after sciatic nerve ligation test. Morphine (10 used as a positive control. Anti-inflammatory assessed xylene-induced edema ears granuloma caused by compressed cotton implantation, respectively. these tests, sodium...
Saffron (Crocus sativus) is a widely used food additive for its color and taste. It has been reported that saffron possesses significant in vivo vitro anti‐tumor activity. In the present study, effects of safranal, major aromatic compound saffron, liposomal form were investigated. The role apoptosis also explored this toxicity. HeLa, MCF7 L929 cell lines cultured exposed to safranal (0.01–3 mM) or (0.04–0.32 mM). 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium (MTT) assay was performed...
The relationship between depression and increased oxidative stress is well known. DNA damage by oxidation factors an important cause of the aging process in psychiatric disorders.Owing to scarcity human studies high inconsistencies effects antidepressants on damage, current study was undertaken investigate its treatment damage.In a 15-week open-label citalopram (n = 25) sertraline 20), levels were measured comet assay, proinflammatory (Interlukin-6 (IL-6)) (8-hydroxy-2'-deoxyguanosine...
ABSTRACT The exposure of embryonic murine limbs in vitro to an activated analog cyclophosphamide, 4-hydroperoxycyclophosphamide (4OOH-CPA), induced limb malformations and apoptosis. purpose this study was investigate the role tumor suppressor/cell cycle checkpoint gene, p53, cell arrest response cyclophosphamide. Limbs, excised on day 12 gestation from wild-type, heterozygous or homozygous p53-knockout transgenic embryos, were treated with vehicle (water) 4OOH-CPA (0.3, 1.0 3.0 μg/ml)...
In this study, the effect of aqueous extract Crocus sativus L. (saffron) stigma was studied against subacute toxicity diazinon (DZN) on specific biochemical markers in rats. Vitamin E (200 IU/kg) and saffron at doses 50, 100 200 mg/kg were injected intraperitoneally three times per week alone or with DZN (20 mg/kg/day, orally) for 4 weeks. Red blood cell (RBC) cholinesterase activity inhibited by not affected vitamin plus DZN. The levels serum tumor necrosis factor-α (inflammation marker),...
This study aimed to evaluate the effect of SSRIs on expression miRNAs and their protein targets.In a 100 day open-label citalopram (n=25) sertraline (n=25), levels miRNA 16, 132, 124 glucocorticoid receptor (GR), Brain-derived neurotrophic factor (BDNF), serotonin transporter (SERT) were measured by QRT-PCR western blot in healthy control (n=20), patients with depression at baseline, same after days treatment.Expression GR BDNF proteins lower depressed group before treatment as compared...
Saffron ( Crocus sativus) is a widely used food additive for its color and taste. Crocin safranal are two main components of this plant. Numerous studies underway to introduce saffron active ingredients as pharmacological agents. Safety assessments these compounds important parts endeavor. In study, the effects crocin administrations during embryogenesis have been investigated in mice. A total 75 BALB/c pregnant mice were divided into six experimental control groups. Four groups received...
Methamphetamine (MAMP) is a central nervous system stimulant that increasingly abused especially by teenagers and young adults, group in its reproductive age. MAMP effects on the male are not clear. In this experimental study, we evaluated of administration proliferation apoptosis seminiferous tubules rat testis. hydrochloride was synthesized iodination norephedrine reduction to methamphetamine. Mature rats were randomly divided into four groups (n=7) injected intraperitoneally with (1, 5 or...
ABSTRACT Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead CO neurotoxicity including lipid peroxidation, inflammatory immune‐mediated reactions, myelin degeneration finally neuronal apoptosis necrosis. Granulocyte colony‐stimulating factor (G‐CSF) is considered be a novel neuroprotective agent. In this study, we evaluated the efficacy of G‐CSF therapy on in rats with acute poisoning....