A5101601627- Wound Healing and Treatments
- Bee Products Chemical Analysis
- Pharmacological Effects and Toxicity Studies
- Cancer Genomics and Diagnostics
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Folate and B Vitamins Research
- Medicinal plant effects and applications
- Surgical Sutures and Adhesives
- Atherosclerosis and Cardiovascular Diseases
- Essential Oils and Antimicrobial Activity
- Diabetes Management and Education
- Alzheimer's disease research and treatments
- Phytochemicals and Antioxidant Activities
- Health and Well-being Studies
- Liver Disease Diagnosis and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Cell Adhesion Molecules Research
- Neuropeptides and Animal Physiology
- Protein Structure and Dynamics
- Diabetes Management and Research
- Parathyroid Disorders and Treatments
- Alkaline Phosphatase Research Studies
Mashhad University of Medical Sciences
2014-2025
Birjand University of Medical Sciences
2015-2025
Arianespace (France)
2017-2023
HRA Pharma (France)
2023
Kashan University of Medical Sciences
2014-2022
Centre National de la Recherche Scientifique
1990-2019
Assistance Publique – Hôpitaux de Paris
2019
Pitié-Salpêtrière Hospital
2019
Sorbonne Université
2019
Inserm
1999-2019
Abstract Introduction The search for drugs to treat Alzheimer's disease (AD) has failed yield effective therapies. Here we report the first genome‐wide biomarkers associated with therapeutic response in AD. Blarcamesine (ANAVEX2‐73), a selective sigma‐1 receptor (SIGMAR1) agonist, was studied 57‐week Phase 2a trial (NCT02244541). study extended further 208 weeks (NCT02756858) after meeting its primary safety endpoint. Methods Safety, clinical features, pharmacokinetic, and efficacy, measured...
The aim of the study was to a nanoliposomal anti-PCSK9 vaccine as novel approach for cholesterol lowering via PCSK9 inhibition.An immunogenic peptide construct termed fused PCSK9-tetanus (IFPT) displayed on surface liposome nanoparticles (L-IFPT) and mixed into alum adjuvant (L-IFPTA+). manufactured formulations IFPT, L-IFPT, L-IFPTA+, IFPTA+, free nanoliposomes were subcutaneously injected four times with bi-weekly intervals in C57BL/6 mice severe atherogenic protocol.Among formulations,...
In vitro follicular culture systems provide optimal models for research about the physiology of ovary and support clinical practices to achieve competent mature oocytes in fertilization. maturation preantral follicles makes it possible study effects therapeutic agents on various conditions or disorders ovary. Nowadays, preventive bioflavonoids against cancer, hypercholesterolemia, fatty liver, a variety toxic are focus. The aim this was design investigate impacts different concentrations...
In recent years, nanotechnology and the subsequent production of nanoparticles have developed excellent methods for medical applications, including wound healing. One these is bentonite (BNPs) which show high ability in tissue engineering. But our knowledge its effectiveness healing based on little data. Therefore, main purpose this study was to evaluate BNPs next step suitability honey as a solvent nanoparticles.
Abstract Introduction In response to the COVID-19 crisis, this study aimed introduce a new virtual teaching model for anatomy education that combines Peer-Assisted Learning (PAL) and flipped classrooms, aligning with constructivist principles. Method The Flipped Peer Assisted (FPA) method was implemented in neuroanatomy course second-year medical students at Birjand University of Medical Sciences via descriptive study. involved small groups PAL, peer learning serving as educational...
Introduction : Hyaluronic acid has been shown to possess notable properties in wound healing, skin regeneration, and anti-inflammatory effects. The formation of scar tissue is a common unintended phenomenon during the wound-healing process, potentially leading diverse consequences for individuals. Aim objective this study was investigate effect injecting synthetic hyaluronic on healing process BALB/c mice subjected suture wounding. Materials methods In experimental study, 18 adult male were...
Saffron ( Crocus sativus) is a widely used food additive for its color and taste. Crocin safranal are two main components of this plant. Numerous studies underway to introduce saffron active ingredients as pharmacological agents. Safety assessments these compounds important parts endeavor. In study, the effects crocin administrations during embryogenesis have been investigated in mice. A total 75 BALB/c pregnant mice were divided into six experimental control groups. Four groups received...
Hyperglycemia-mediated oxidative stress implicates in etiology of kidney cell aging and diabetic nephropathy. We evaluated the effects different doses resveratrol quercetin their combination therapy on marker human culture under hyperglycemia condition.Human embryonic (HEK-293) was cultured Dulbecco's Modified Eagle Medium (DMEM) containing 100 mM (18 mg/L) for 24 h. The cells were treated with (2.5, 5, 10 μm), (3, 6, 12 these (R 2.5 μm, Q 3 μm) 5 6 48 h, then, lysed to access RNA lysate.The...
Comparison of the Efficacy Honey and Animal Oil inAccelerating Healing Full Thickness Wound mice skin Comparación de la Eficacia Miel y Aceite en Aceleración Cicatrización Herida Todo el Espesor Piel
The goal of this study was to determine the effect topical Emu oil on healing burn wounds and hair follicle restoration in superficial II-degree burns skin Balb/c mice. Thirty-two male mice with back neck were divided into two groups: group received twice daily, whereas control left untreated. Skin biopsies obtained days 4, 7, 10, 14 experiment. Then specimens viewed Olympus SZX research microscope. treated found heal more slowly inflammation lasted longer group. number follicles margins...
Alzheimer's disease (AD)—a complex showing multiple pathomechanistic alterations—is triggered by nonlinear dynamic interactions of genetic/epigenetic and environmental risk factors, which, ultimately, converge into a biologically heterogeneous disease. To tackle the burden AD during early preclinical stages, accessible blood-based biomarkers are currently being developed. Specifically, next-generation clinical trials expected to integrate positive negative predictive study designs evaluate,...
Up to now, proper wound care management has remained as an important clinical challenge. Chitosan nanosheets (CNSs) showed a great potential in tissue engineering, but our knowledge about their healing effectiveness is based on very limited data. Thus, the aim of this research was evaluate CNSs and honey vehicle for these nanoparticles.
Background The risk of hospitalization or death after influenza infection is higher at the extremes age and in individuals with comorbidities. We estimated number hospitalizations characterized cumulative comorbidities on severe outcomes Mexico Brazil. Methods used national hospital discharge data from Brazil (SIH/SUS) 2010–2018 (SAEH) 2010–2017 to estimate admissions using ICD-10 codes, stratified by (0–4, 5–17, 18–49, 50–64, ≥65 years). Duration stay, admission intensive care unit (ICU),...
The present investigation was carried out to evaluate the protective effect of hydroalcoholic extract Urtica dioica leaves on quantitative morphometric changes in liver streptozotocin-induced diabetic rats.Thirty male Wistar rats were divided into control (G1), (G2), + (G3) groups. group received only sham injections intraperitoneal saline; saline for 5 days followed by streptozotocin (80 mg/kg) 6th day; and 100 mg/kg (7) injection day. After five weeks, animals sacrificed whole livers...
We aimed to discriminate between typical and atypical developmental trajectory patterns of at-risk infants in an interactive setting this observational longitudinal study, with the assumption that hand movements (HM) reflect preverbal communication its disorders. examined trajectories HM five cohorts one control cohort, followed from ages 2 10 months: 25 West syndrome (WS), 13 preterm birth (PB), 16 orality disorder (OD), 14 visually impaired mothers (VIM), 7 early hospitalization (EH), 19...