A5020666336- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Vascular anomalies and interventions
- Cardiac Arrhythmias and Treatments
- Williams Syndrome Research
- Cardiovascular Health and Disease Prevention
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Tracheal and airway disorders
- Blood Coagulation and Thrombosis Mechanisms
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- Regulation of Appetite and Obesity
- Long-Term Effects of COVID-19
- Neuroendocrine regulation and behavior
Texas Children's Hospital
2020-2025
Baylor College of Medicine
2015-2025
University of Pittsburgh Medical Center
2024
Icahn School of Medicine at Mount Sinai
2015-2018
Children's Hospital of San Antonio
2015-2017
Columbia University
2015
Columbia University Irving Medical Center
2014
Morgan Stanley Children's Hospital
2014
University of Akron
1983
Hypoplastic left heart syndrome (HLHS) is a congenital disease responsible for 23% of infant cardiac deaths each year in the United States. HLHS patients are born with an underdeveloped heart, requiring several surgeries to reconstruct aorta and create single-ventricle circuit known as Fontan circulation. While survival into early adulthood becoming more common, often have reduced output, putting them at risk multitude complications. These monitored using chest neck magnetic resonance...
Abstract Aims Data on mitral annular disjunction (MAD) in children with Marfan syndrome (MFS) are sparse. To investigate the diagnostic yield of MAD by echocardiography and cardiac magnetic resonance imaging (CMR), its prevalence progression during childhood. Methods results We included patients <21 years old MFS, defined 2010 Ghent criteria a pathogenic FBN1 variant or ectopia lentis. Two readers measured systolic separation between valve (MV) posterior hinge point left ventricular...
Objective Marfan syndrome (MFS)-associated cardiomyopathy, defined as ventricular dilation and dysfunction unexplained by volume loading, is not well in children. This study evaluated size function paediatric MFS using cardiac MRI (cMRI). Methods retrospective cohort examined patients with <19 years old at first cMRI. Left (LV) ejection fraction (EF) <55% was considered abnormal, were z-scores >2. Combined mitral aortic regurgitation indexed to LV stroke <20% absent/mild load....
The following experiments were designed to determine if territorial stress, dietary sodium (Na), or the combination of stress and Na effect rate development hypertension in spontaneously hypertensive rat (SHR 4-18 wks) central catecholamines (C) altered by these treatments. BP was significantly elevated from 2-8 weeks treatment as compared SHR controls. Norepinephrine (NE) levels nucleus tractus solitarius amygdala (A), dopamine (D) hippocampus A showed significant elevations stressed group....
Anomalous aortic origin of a coronary artery from the wrong Sinus Valsalva (AAOCA) is rare congenital anomaly and associated with sudden cardiac death. Morphologic features considered to be "high risk" are significant luminal narrowing, acute angulation at its origin, intramural course, long interarterial course. A consistent approach for characterization these lacking.A retrospective single-center review all patients diagnosed AAOCA using echocardiogram computed tomography (CT)/magnetic...
Purpose To develop an end-to-end deep learning (DL) pipeline for automated ventricular segmentation of cardiac MRI data from a multicenter registry patients with Fontan circulation (Fontan Outcomes Registry Using CMR Examinations [FORCE]). Materials and Methods This retrospective study used 250 examinations (November 2007-December 2022) 13 institutions training, validation, testing. The contained three DL models: classifier to identify short-axis cine stacks two U-Net 3+ models image...
Fontan patients exhibit decreased exercise capacity. However, there is a subset of high-performing (HPF) with excellent
Abstract Background Atrial transseptal puncture (TSP) for cardiac catheterization procedures remain challenging in children and adults with complex congenital heart disease (CHD). Objectives We sought to evaluate our experience using radiofrequency (RF) current via surgical electrocautery needle TSP facilitate diagnostic interventional procedures. Methods Retrospective chart review of all patients (pts) who underwent RF energy (10–25 W) from three centers January 2011 2017 were evaluated....
Background Arterial tortuosity is associated with adverse events in Marfan and Loeys-Dietz syndromes but remains understudied Vascular Ehlers-Danlos syndrome. Methods Results Subjects a pathogenic COL3A1 variant diagnosed at age <50 years were included from 2 institutions the GenTAC Registry (National of Genetically Triggered Thoracic Aortic Aneurysms Cardiovascular Conditions). Height-adjusted vertebral artery index (VTI-h) using magnetic resonance or computed tomography angiography was...
We aimed to describe the frequency and yield of genetic testing in supravalvar aortic stenosis (SVAS) following negative evaluation for Williams-Beuren syndrome (WS).
One-dimensional (1D) cardiovascular models offer a non-invasive method to answer medical questions, including predictions of wave-reflection, shear stress, functional flow reserve, vascular resistance and compliance. This model type can predict patient-specific outcomes by solving 1D fluid dynamics equations in geometric networks extracted from images. However, the inherent uncertainty vivo imaging introduces variability network size vessel dimensions, affecting haemodynamic predictions....
Repair of anomalous left coronary artery from the right pulmonary presents a particular technical challenge to congenital cardiac surgeon. There is disagreement in literature over optimal technique for this defect, with some authors advocating unroofing periaortic segment artery, while others prefer direct aortic reimplantation artery.We performed retrospective study examining outcomes patients who were repaired anomaly at our institution. In-hospital and outpatient follow-up data...
This case describes an infantile presentation of left main coronary artery atresia (LMCAA), which involves complete absence the ostium and artery. The echocardiographic features LMCAA that assist in making this diagnosis are detailed. Important imaging distinguish from anomalous pulmonary highlighted.
Scimitar syndrome is a rare CHD composed of partial anomalous pulmonary venous connection from the right lung, via scimitar vein, to inferior vena cava rather than left atrium. Genetic conditions associated with have not been well investigated at present.Our study included patients diagnosed Texas Children's Hospital January 1987 July 2020. Medical records were evaluated determine if genetic testing was performed, including chromosomal microarray analysis or whole-exome sequencing. Copy...