More than 50% of the world population is infected with Helicobacter pylori (H. pylori). Potential anti-adhesive peptides from corn protein hydrolysate were developed using in vitro methodologies to prevent infection. To obtain against pylori, gluten meal (CGM) was hydrolyzed by neutrase, and (CPHN) purified Superdex peptide gel filtration, Q anion exchange Mono exchange. Then, sequences identified Nano-LC-MS/MS, structural functional properties characterized. Three novel Pro-Tyr-Ala-Glu-Tyr...

This study aimed to clarify the effect of lactic acid bacteria-fermented corn protein hydrolysate (FCH) on fatigue in mice and explore connection between fatigue-related indicators intestinal microbial flora. The model was constructed by exercise endurance experiment. anti-fatigue level FCH evaluated measuring physiological biochemical indexes mouse serum, liver skeletal muscle. relationship FCH, flora explored through analysis diversity mice, mechanism further analyzed. results showed that...

This study investigated the potential effects of corn protein activity peptides (CPAPs) on inflammation response levels and gastrointestinal microbiota in Helicobacter pylori (H. pylori) infection mice. CPAPs significantly up-regulated mRNA expression anti-inflammatory factor IL-10 down-regulated pro-inflammatory factors TGF-β, TLR4, MyD88, NF-κB, indicating that may antagonize H. pylori-induced inflammatory responses by inhibiting NF-κB signaling pathways. Through intervention CPAPs,...

More than 50% of the world population is infected with Helicobacter pylori (H. pylori), which classified as group I carcinogen by WHO. H. surface adhesins specifically recognize gastric mucosal epithelial cells' (GES-1 cells) receptor to complete adhesion. Blocking adhesion an anti-adhesion compound effective way prevent infection. The present study found that corn protein hydrolysate, hydrolyzed Neutral, effectively alleviated injury induced infection through anti-adhesive and...

Cisplatin-based chemotherapy is commonly used for the clinical treatment of patients with non-small cell lung cancer (NSCLC). However, anti-tumor efficacy cisplatin limited by poor response and development chemoresistance. At present, underlying mechanism resistance remains unclear. In present study, it was identified that metastasis-associated adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA has been demonstrated to function as an oncogene, increased in tumor tissues from...

Alcohol dehydrogenase (ADH) plays a pivotal role in constraining alcohol metabolism. Assessing the ADH-activating activity vitro can provide insight into capacity to accelerate ethanol metabolism vivo. In this study, peptides were prepared from corn protein meal (CGM) using enzymatic hydrolysis, and these subsequently identified following simulated gastrointestinal digestion their absorption through Caco-2 cell monolayer membrane. The current investigation revealed that hydrolysate...

Melon Fusarium wilt (MFW), which is caused by oxysporum f. sp. melonis (FOM), a soil-borne disease that commonly impacts melon cultivation worldwide. In the absence of any disease-resistant cultivars, control MFW relies heavily on application chemical fungicides. Fludioxonil, phenylpyrrole fungicide, has been shown to have broad-spectrum activity against many crop pathogens. Sensitivity analysis experiments suggest fludioxonil strong inhibitory effect mycelial growth FOM isolates. Five...

Abstract BACKGROUND More than 50% of the world's population is infected with Helicobacter pylori , which classified as a group I carcinogen by World Health Organization (WHO). RESULTS Corn protein dual‐functional peptides were identified and functionally analyzed in vitro silico . Two novel Cys‐Gln‐Asp‐Val‐Pro‐Leu‐Leu (CQDVPLL, CQ7) Thr‐Ile‐Phe‐Pro‐Gln‐Cys (TIFPQC, TI6) using nanoscale liquid chromatography coupled to tandem mass spectrometry (nano‐LC–MS/MS). The antiadhesive effects against...

海南岛大规模二叠-三叠纪侵入岩的形成是与古特提斯洋有关, 还是与古太平洋俯冲闭合有关还存在巨大争议。本文对琼中金波两处辉绿岩脉及其围岩花岗岩的研究显示, 露头1辉绿岩脉的锆石U-Pb年龄为245.4±3.8Ma, TiO₂含量(1.07%~1.18%)低, 而MgO(8.60%~9.41%)和Mg^#值(62.31~65.02)较高, 为钙碱性系列, 球粒陨石和原始地幔标准化配分曲线中具有明显的Eu、Nb、Ta、Ti和Ba负异常, 以及显著Th、U、Zr、Rb和Pb等正异常, (⁸⁷Sr/⁸⁶Sr)_i=0.707138~0.712797, (¹⁴³Nd/¹⁴⁴Nd)_i=0.511884~0.511965, <i>ε</i>_Nd(<i>t</i>)值为-7.01~-8.58, 指示其形成于大陆岛弧环境。相比之下, 露头2辉绿岩锆石U-Pb年龄为242.8±3.1Ma,...

H. pylori is a highly pathogenic and prevalent pathogen that class I carcinogen. More than 50% of the world's population infected with pylori. An anti-adhesive strategy an effective way to antagonize infection, which does not cause resistance safer compared antibiotic therapy. In present study, obtain rice bran protein-derived activity peptides against pylori, efficient enzymatic hydrolysis system was established, it found protein hydrolysate prepared under specific conditions possessed The...

This study examines the impact of GDP growth rate and inflation on revenue nine major listed companies (e.g., Alibaba, Pinduoduo, etc.) in China from 2015 to 2023 through multiple regression analysis. It is found that significantly positively related firms’ growth, while effect not statistically significant. reflects overall performance economic activities an important predictor whereas China’s has been relatively stable during period, therefore a weak predictive growth. The theoretical...

The ophiolites that crop out discontinuously along the ∼2000 km Yarlung Zangbo Suture zone (YZSZ) between Nanga Parbat and Namche Barwa syntaxes in southern Tibet represent remnants of Neotethyan oceanic lithosphere (Fig. 1a). We have investigated internal structure geochemical makeup mafic‐ultramafic rock assemblages are exposed westernmost segment YZSZ where suture architecture displays two distinct sub‐belts ophiolitic mélange units separated by a continental Zhongba terrane 1b). These...

雅鲁藏布江缝合带西段出露东波和普兰等多个大型的超镁铁岩体，其成因还存在争议。为此我们近年来对东波蛇绿岩开展了地表填图并实施了一口1002m的科学钻探DSD-1。研究显示具有厚幔极薄壳特征的东波蛇绿岩记录了多期岩浆事件：（1）~137Ma的OIB型玄武岩和138~144Ma的OIB型辉绿岩和辉长岩，以及普遍出露熔融程度达30%以上的亏损型方辉橄榄岩，反映了早白垩世初期古洋盆受到地幔柱活动影响；（2）129Ma的薄壳均质辉长岩（I型）、128Ma的辉长岩脉（Ⅱ型）和科钻岩芯中厚18m辉绿岩（Ⅲ型）的地球化学成分均与西南印度洋洋脊玄武岩类似，它们是在慢速-超慢速扩张脊附近大洋核杂岩侵位过程中形成的；（3）地表辉绿岩脉（Ⅳ型）的SIMS和SHRIMP锆石U-Pb年龄为121~123Ma，全岩地球化学具有异常低的REE、HFSE含量及明显的Th、Nb、Zr、Hf负异常，类似于Albanide-Hellenide造山带蛇绿岩中的无壳源物质混染的中钛玄武岩，指示辉绿岩脉形成于洋内初始俯冲环境。总的来说，东波蛇绿岩记录了早白垩世地幔柱影响的超慢速扩张和初始洋内俯冲过程。;The genesis...

Abstract The Dingqing ophiolite is located in the eastern segment of Bangong‐Nujiang suture zone. This zone W–E trending parallel with Yarlung–Zangbo and an strategic area for exploring chromite deposits China. Dingqign distributed near SE‐NW direction. According to spatial distribution, sudivided into two massifs, including East West massifs. covers nearly 600 km 2 . composed peridotite, pyroxenite, gabbro, diabase, basalt, plagiogranite chert (Fig. 1). peridotite main lithology ophiolite....

蛇绿岩是侵位在陆缘的古大洋岩石圈残片, 是记录古洋盆从形成到消亡的直接载体。因此, 蛇绿岩的研究可以为揭示和恢复古洋陆构造体制和演化历史提供有力的证据。围绕蛇绿岩进行的野外地质调查与填图是开展铬铁矿、地幔橄榄岩及洋壳单元岩石成因研究的基础。根据丁青蛇绿岩中方辉橄榄岩的矿物组成、结构、构造和矿物化学等特征, 将其划分为块状、斑杂状、辉石定向状、球粒状和糜棱岩化方辉橄榄岩五种类型, 并通过1 : 5万地质填图在拉拉卡测区首次发现五种类型的方辉橄榄岩在区域上存在明显的岩相分带特征: 块状方辉橄榄岩岩相带呈条带状分布于拉拉卡测区中部, 两侧对称出现斑杂状方辉橄榄岩岩相带。少量的辉石定向状方辉橄榄岩岩相带呈透镜状分布在块状方辉橄榄岩岩相带内部或边缘, 极少量的球粒状方辉橄榄岩的产出与基性侵入岩相关, 而糜棱岩化方辉橄榄岩岩相带呈细长条带出露于橄榄岩岩块南缘。铬铁矿矿点或矿化点的分布、类型和规模与地幔橄榄岩岩相分带在空间上存在一定的相关性, 二十余处高铬型铬铁矿矿点分布在斑杂状方辉橄榄岩岩相带中,...

Abstract The Peng Co ophiolite is located to the west of lake in area lakes north Tibet, which belongs Baila‐Yilashan sub‐belt middle Bangong Co‐Nujiang ophiolitic belt. mainly composed mantle peridotites, cumulates, diabase dikes. About 70 percent peridotites are harzburgites and 30 lherzolites. Mineral chemistry lherzolitesare characterized by low Fo contents (88.85–90.33) olivine high Al 2 O 3 content (4.26%–7.25%) pyroxenes. Compared primitive mantle, have relatively higher MgO contents,...