A5039243653- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- Additive Manufacturing and 3D Printing Technologies
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Laser Applications in Dentistry and Medicine
- Speech and Audio Processing
- Hand Gesture Recognition Systems
- Hearing Loss and Rehabilitation
- Endodontics and Root Canal Treatments
- AI in cancer detection
- Artificial Intelligence in Healthcare
- Artificial Intelligence in Healthcare and Education
- Phonocardiography and Auscultation Techniques
- Advanced Adaptive Filtering Techniques
- Animal testing and alternatives
- Periodontal Regeneration and Treatments
- Dental materials and restorations
- Temporomandibular Joint Disorders
- Mesenchymal stem cell research
University of Oklahoma
2020-2023
University of Utah
2022
North Carolina State University
2016-2021
Bioinks play a central role in 3D-bioprinting by providing the supporting environment within which encapsulated cells can endure stresses encountered during digitally driven fabrication process and continue to mature, proliferate, eventually form extracellular matrix (ECM). In order be most effective, it is important that bioprinted constructs recapitulate native tissue milieu as closely possible. As such, musculoskeletal soft benefit from bioinks mimic their nanofibrous constitution, also...
The limitations and high false-negative rates (30%) of COVID-19 test kits have been a prominent challenge during the 2020 coronavirus pandemic. Manufacturing those performing tests require extensive resources time. Recent studies show that radiological images like chest X-rays can offer more efficient solution faster initial screening patients. In this study, we develop diagnosis model using Multilayer Perceptron Convolutional Neural Network (MLP-CNN) for mixed-data (numerical/categorical...
The COVID-19 global pandemic caused by the widespread transmission of novel coronavirus (SARS-CoV-2) has become one modern history's most challenging issues from a healthcare perspective. At its dawn, still without vaccine, contagion containment strategies remained effective in preventing disease's spread. Patient isolation been primarily driven results polymerase chain reaction (PCR) testing, but initial reach was challenged low availability and high cost, especially developing countries....
Chest radiographs (X-rays) combined with Deep Convolutional Neural Network (CNN) methods have been demonstrated to detect and diagnose the onset of COVID-19, disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). However, questions remain regarding accuracy those as they are often challenged limited datasets, performance legitimacy on imbalanced data, their results typically reported without proper confidence intervals. Considering opportunity address these issues,...
Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture native extracellular matrix. However, it generates limited three-dimensional structures relevant physiological thicknesses. 3D printing allows digitally controlled fabrication single/multimaterial constructs precisely ordered in single build. this approach generally lacks ability to achieve submicron resolution features mimic tissue. The goal study was...
Abstract Osteoarthritis is a degenerative joint disease that limits mobility of the affected due to degradation articular cartilage and subchondral bone. The limited regenerative capacity presents significant challenges when attempting repair or reverse effects degradation. Tissue engineered medical products are promising alternative treat osteochondral degeneration their potential integrate into patient's existing tissue. goal this study was create scaffold would induce site‐specific...
Tissue engineering and regenerative medicine approaches have the potential to overcome challenges associated with current treatment strategies for meniscus injuries. 3D-Bioplotted scaffolds are promising, but not demonstrated ability guide formation of aligned collagenous matrix in vivo, which is critical generating functional tissue. In this study, we evaluate scaffold designs varying interstrand spacing induce deposition vivo.3D-Bioplotted polycaprolactone 100, 200, or 400 μm were...
Purpose: Musculoskeletal soft tissues possess highly aligned extracellular collagenous networks that provide structure and strength. Such an organization dictates tissue-specific mechanical properties but can be difficult to replicate by engineered biological substitutes. Nanofibrous electrospun scaffolds have demonstrated the ability control cell-secreted collagen alignment, concerns exist regarding their scalability for larger anatomically relevant applications. Additive manufacturing...
Experimental adhesives with functional nitrogen-doped titanium dioxide nanoparticles (N_TiO2) have been shown to display improved properties. However, these materials not characterized regarding their degree of conversion (DC), biaxial flexure strength (BFS), surface roughness (SR), elastic modulus (EM), and long-term antibacterial functionalities. were synthesized by dispersing N_TiO2 (10%, 20%, or 30%, v/v%) into OptiBond Solo Plus (OPTB, Kerr Corp., USA). Unpolymerized (volume = 50...
There is a need for the development of effective treatments focal articular cartilage injuries. We previously developed multiphasic 3D-bioplotted osteochondral scaffold design that can drive site-specific tissue formation when seeded with adipose-derived stem cells (ASC). The objective this study was to evaluate in large animal model. Osteochondral defects were generated trochlear groove Yucatan minipigs and repaired scaffolds either contained or lacked an electrospun tidemark unseeded ASC....
Regenerative medicine approaches to restore the mandibular condyle of temporomandibular joint (TMJ) may fill an unmet patient need. In this study, a method implant acellular regenerative TMJ prosthesis was developed for orthotopic implantation in pilot goat study. The scaffold incorporated porous, polycaprolactone-hydroxyapatite (PCL-HAp, 20wt% HAp) 3D printed with cartilage-matrix-containing hydrogel. A series material characterizations used determine structure, fluid transport, and...
Speech perception in an adverse background/noisy environment is a complex and challenging human process, which made even more complicated foreign-accented language for bilingual monolingual individuals. Listeners who have difficulties hearing are affected most by such situation. Despite considerable efforts, the increase speech intelligibility noise remains elusive. Considering this opportunity, study investigates Bengali–English bilinguals native American English monolinguals’ behavioral...
Bioprinting is a rapidly emerging area of study within Tissue Engineering and Regenerative Medicine (TERM) where live cells are be embedded in solution (referred to as bioink) 3D printed into anatomically relevant geometries for vivo implantation; this allows native tissues regenerate better faster. Most current research investigates the mechanical, rheological, biological properties bioinks, but few methods have been proposed mathematically rank bioinks based on set application-focused,...