Abstract Introduction To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment cartilage injury. Therefore, in this study we tested whether gene growth Indian hedgehog (IHH) was able to induce chondrogenesis human primary MSCs, and it possible by such an approach modulate appearance chondrogenic hypertrophy pellet cultures vitro . Methods First-generation adenoviral vectors encoding cDNA IHH were created...

This case report presents the clinical findings and management of a 32-year-old male recreational athlete who presented with ongoing knee pain for 4 months, without history trauma. The patient experienced intermittent during walking, particularly after prolonged periods sitting, exhibited positive on meniscus tests. However, he was able to participate in sports activities pain. Magnetic resonance imaging (MRI) revealed partial tear medial gastrocnemius head, confirming diagnosis....

[Purpose] A wide variety of accelerometer tools are used to estimate human movement, but there no adequate data relating gait symmetry parameters in the context knee osteoarthritis. This study's purpose was evaluate a 3D-kinematic system using body-mounted sensors (gyroscopes and accelerometers) on trunk limbs. is first study use spectral analysis for post processing. [Subjects] Twelve patients with unilateral osteoarthritis (OA) (10 male) seven age-matched controls (6 were studied....

To stimulate healing of large bone defects research has concentrated on the application mesenchymal stem cells (MSCs).In present study, we induced overexpression growth factors morphogenetic protein 2 (BMP-2) and/or Indian hedgehog (IHH) in human MSCs by adenoviral transduction to increase their osteogenic potential. GFP and nontransduced served as controls. The influence respective genetic modification cell metabolic activity, proliferation, alkaline phosphatase (ALP) mineralization...

Abstract Background Mesenchymal stem cell (MSC) based-treatments of cartilage injury are promising but impaired by high levels hypertrophy after chondrogenic induction with several bone morphogenetic protein superfamily members (BMPs). As an alternative, this study investigates the MSCs via adenoviral gene-delivery transcription factor SOX9 alone or in combination other inducers, and comparatively explores end stage differentiation a pellet culture system vitro. Methods First generation...

The Goutallier Classification is a semi quantitative classification system to determine the amount of fatty degeneration in rotator cuff muscles. Although initially proposed for axial computer tomography scans it currently applied magnet-resonance-imaging-scans. role its clinical use controversial, as reliability has been shown be inconsistent. purpose this study was compare MRI-based by 5 different raters experimental MR spectroscopic fat measurement order correlation between and true...

Fatty Degeneration (FD) of the rotator cuff muscles influences functional and anatomical outcome after repair. The MRI based estimation fatty degeneration is gold standard. There some evidence that Ultrasound elastography (EUS) can detect local differences tissue stiffness in tendons. Shear-wave (SWE) was evaluated to determine extent which shear wave velocity associated with measures degeneration. MRI-spectroscopic fat measurement used as a reference quantify amount muscle belly. Forty-two...

Abstract The administrative burden for physicians in the hospital can affect quality of patient care. Service Center Medical Informatics (SMI) University Hospital Würzburg developed and implemented smartphone-based mobile application (MA) ukw.mobile 1 that uses speech recognition point-of-care ordering radiological examinations. aim this study was to examine usability MA workflow All at Department Trauma Plastic Surgery Würzburg, Germany, were asked participate a survey including short...

Introduction: The long head of the biceps (LHB) is often resected in shoulder surgery. However, its contribution to inflammatory processes remains unclear. In present study, inflamed and noninflamed human LHBs were comparatively characterized for features inflammation. Materials methods: Twenty-two LHB tendons classified into ( n = 11) samples. For histological examination, samples stained with hematoxylin eosin, Azan, van Gieson, Masson Goldner trichrome. Neuronal tissue was...

The long head of the biceps (LHB) is often resected in shoulder surgery and could therefore serve as a cell source for tissue engineering approaches shoulder. However, whether it represents suitable regenerative approaches, both inflamed non-inflamed states, remains unclear. In present study, native human LHBs were comparatively characterized features regeneration.In total, 22 LHB tendons classified into samples (n = 11) 11). Proliferation potential specific marker gene expression primary...

Representing 3%-5% of shoulder girdle injuries scapula fractures are rare. Furthermore, approximately 1% intraarticularfractures the glenoid fossa. Because uncertain fracture morphology and limited experience, treatment fossa is difficult. The classification by Ideberg (1984) Euler (1996) still commonly used in literature. In 2013 a new was introduced AO. purpose this study to examine AO clinical practice comparison with classifications Euler.In total CT images 84 patients from 2005 2018...

Vascular damage in polytrauma patients is associated with high mortality and morbidity. Therefore, specific clinical implications of vascular fractures major trauma are reassessed. This comprehensive nine-year retrospective single center cohort study analyzed demography, laboratory, treatment outcome data from 3689 patients, 64 fracture-associated injuries were identified compared to a control group. Results: occurred 7% upper lower limb pelvic admitted the room. Overall survival was 80%...

Displaced midshaft clavicular fractures can be treated conservatively as well operatively by titan elastic nail (TEN) or plate fixation. This survey was performed to evaluate the clinical results of each treatment method and elaborate advantages possible complications modality. Between 2008 2013, 102 patients were prospectively included in our study—37 for conservative with a rucksack bandage 4 6 weeks, 41 osteosynthesis, 24 intramedullary stabilization TEN. Disabilities Arm, Shoulder Hand...

Avascular necrosis of the humeral head after proximal fracture i.e. type 1 sequelae (FS) according to Boileau classification is a rare, often painful condition and treatment still remains challenge. This study evaluates FS with anatomic reverse shoulder arthroplasty new subclassification proposed.This single-center, retrospective, comparative study, included all consecutive patients treated surgically in four-year period. All were classified proposed 3 different subtypes. Constant score...

Separation of the pubic symphysis with corresponding diastasis can be stabilized by symphyseal plating.Which pelvic injuries are plating and what is their outcome?A retrospective evaluation 64 patients who underwent over a period 24 months was conducted.Of 56 were male 8 female mean age 44 years (SD ± 17 years). The main cause traffic accidents. distribution according to AO fracture classification 14 × B1, 10 B2, 5 B3, 23 C1, 9 C2 3 C3 injuries. Young Burgess showed APC I, 18 II, 13 III, LC...

The amount of fatty degeneration (FD) has major impact on the clinical result and cuff integrity after rotator repair. A quantitative analysis with magnet resonance imaging (MRI) spectroscopy was employed to analyze possible correlation FD tendon retraction, thickness patients' characteristics in full supraspinatus tears.Forty-two patients full-thickness tears underwent shoulder MRI including an experimental spectroscopic sequence allowing quantification fat fraction muscle belly. correlated...

Abstract Background For improved outcomes in total knee arthroplasty (TKA) correct implant fitting and positioning are crucial. In order to facilitate a best possible patient-specific systems have been developed. However, whether or not these allow for better has yet be elucidated. this reason, the aim was analyse novel cruciate retaining replacement system iTotal™ CR G2 that utilizes custom-made implants instruments its ability accurate including correction of hip-knee-ankle angle (HKA)....