Abstract Introduction To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment cartilage injury. Therefore, in this study we tested whether gene growth Indian hedgehog (IHH) was able to induce chondrogenesis human primary MSCs, and it possible by such an approach modulate appearance chondrogenic hypertrophy pellet cultures vitro . Methods First-generation adenoviral vectors encoding cDNA IHH were created...

Alignment strategies for primary total knee arthroplasty (TKA) have changed significantly over time with a shift towards more individualized alignment goal. At the same time, computer-assisted surgery (CAS) has gained interest intraoperative control and accuracy in implant positioning limb alignment. Despite often discussed benefits drawbacks of robotics navigation TKA, routine use these new devices on day-to-day basis remains obscure. Therefore, nationwide hospital billing data based...

The direct anterior approach (DAA) represents a well-recognized soft tissue sparing technique for primary total hip arthroplasty (THA). feasibility and suitability of the DAA in cases complex acetabular deformities, namely coxa profunda (CP) protrusio acetabuli (PA), remain to be determined.A 188 CP (100 cases) PA (88 hips undergoing THA via were retrospectively analyzed. Surgical radiographic parameters evaluated potential complications assessed. Finally, successful implantation was defined...

In March 2020, Germany imposed a nationwide lockdown to curb the spread of COVID-19, prompting questions about impact on incidence common fractures. This study examined 15 fracture types in pre-outbreak (2010-2019) and post-outbreak (2020-2021) periods, using data categorized by age (18-64 years, >65 years) sex (male, female). Linear regression assessed annual growth rates, mean numbers were compared across periods for significant differences. Results indicated positive correlation between...

Vitamin D is crucial for ideal bone health and good muscle function, both essential requirements successful joint arthroplasty. Hence, vitamin deficiency has recently been identified as a predictor of poorer outcomes in patients scheduled to undergo total arthroplasty (TJA). Moreover, there ample evidence today that associated with periprosthetic infection. Yet, seems be frequent who are TJA. However, the prevalence hypovitaminosis require revision (rTJA) largely unknown. Further, risk...

Abstract Background Mesenchymal stem cell (MSC) based-treatments of cartilage injury are promising but impaired by high levels hypertrophy after chondrogenic induction with several bone morphogenetic protein superfamily members (BMPs). As an alternative, this study investigates the MSCs via adenoviral gene-delivery transcription factor SOX9 alone or in combination other inducers, and comparatively explores end stage differentiation a pellet culture system vitro. Methods First generation...

Direct anterior approach total hip replacement (DAA-THR) is gaining increased interest due to its tissue-sparing nature and rapid recovery. Obesity has been shown be a significant parameter influencing cup positioning in DAA-THR. It was the intention of this retrospective study examine how obesity would influence restoration native biomechanical parameters during A 74 patients from high-volume university orthopedic center after unilateral DAA-THA were included. Patients retrospectively...

Evaluation of infection persistence during the two-stage exchange hip is challenging. Joint aspiration before reconstruction supposed to rule out persistence. Sensitivity and specificity synovial fluid culture leucocyte count for detecting were evaluated. Ninety-two aspirations planned joint with spacers retrospectively analyzed. The sensitivity was 4.6 94.3%. at a cut-off value 2000 cells/μl 25.0 96.9%. C-reactive protein (CRP) erythrocyte sedimentation rate (ESR) values significantly...

Abstract Introduction Focal cartilage defects of the knee are often treated with arthroscopic debridement. Existing literature discussing benefit debridement for small articular lesions is scarce, especially if was not part a combined operative procedure including meniscal and ligament repair. The purpose this study to examine patients´ after treatment isolated focal chondral or without partial meniscus resection. Materials methods Baseline (preoperative data) 12-month follow-up five Knee...

Objective As native cartilage consists of different phenotypical zones, this study aims to fabricate types neocartilage constructs from collagen hydrogels and human mesenchymal stromal cells (MSCs) genetically modified express chondrogenic factors. Design Human MSCs derived bone-marrow osteoarthritis (OA) hips were using adenoviral vectors encoding sex-determining region Y-type high-mobility-group-box (SOX) 9, transforming growth factor beta (TGFB) 1 or bone morphogenetic protein (BMP) 2...

This study was designed to investigate the image quality of ultra-high-resolution ankle arthrography employing a photon-counting detector CT. Bilateral arthrograms were acquired in four cadaveric specimens with full-dose (10 mGy) and low-dose (3 scan protocols. Three convolution kernels different spatial frequencies utilized for reconstruction (ρ50; Br98: 39.0, Br84: 22.6, Br76: 16.5 lp/cm). Seven radiologists subjectively assessed regarding depiction bone, hyaline cartilage, ligaments. An...

Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies. Here we established prototype foamyviral vectors (FVV) that are derived from apathogenic parent viruses characterized by a broad host range favourable integration pattern into the cellular genome. As inflammatory cytokine interleukin 1 beta (IL1β) is frequently present diseased joints,...

Rapidly destructive osteoarthritis (RDO) of the hip joint is characterised by rapid destruction femoral head with or without acetabular involvement. There has been increasing interest in this disease over past years; however, entity still poorly understood, and its pathophysiology remains unknown. Yet, there ample evidence today that increased bone metabolism might play a role onset progression disease. Vitamin D utmost importance to maintain balanced metabolism. However, whether vitamin...

Cartilage repair techniques for chondral defects in the hip are crucial treating conditions like femoroacetabular impingement, developmental dysplasia, and osteonecrosis, especially young patients to delay progression of osteoarthritis. This study aims present age sex distributions trends hip-preserving surgeries Germany from 2006 2022, analyzing 116,179 procedures using German OPS coding system. The were categorized into three groups: debridement, refixation, regeneration. Arthroscopy was...

Despite increasing numbers of primary hip arthroplasties performed through the direct anterior approach (DAA), there is a lack literature on DAA revision arthroplasty. The present study was in order to evaluate outcomes and rates after using an asymmetric acetabular component with optional intra- extramedullary fixation. In retrospective cohort study, we analyzed prospectively collected data 57 patients (61 hips, 43 female, 18 male) who underwent aseptic abovementioned implant system between...

Vitamin D deficiency is a global health concern that estimated to afflict over one billion people globally. The major role of vitamin regulator calcium and phosphate metabolism, thus, being essential for proper bone mineralisation. Concomitantly, known exert numerous extra-skeletal actions. For example, it has become evident direct anti-proliferative, pro-differentiation pro-apoptotic actions on cancer cells. Hence, been associated with increased risk worse prognosis in several malignancies....

Contradicting definitions of periprosthetic joint infection (PJI) are in use. Joint aspiration is performed before total hip arthroplasty (THA) revision. This study investigated the influence PJI definition on prevalence at THA Test quality prerevision was evaluated for different definitions.256 revisions were retrospectively classified to be infected or not infected. Classification according 4 proposed by Musculoskeletal Infection Society (MSIS), Infectious Diseases America (IDSA),...

Background : As advanced age often leads to accumulating comorbidities, geriatric patients are endangered by serious events during total hip arthroplasty. This study was conducted explore whether or not the benefit in terms of health-related quality life (HRQoL) comparable younger patients. Methods At a single academic center, 100 meeting following inclusion criteria were retrospectively recruited: (1) primary arthritis leading THA; (2) 80 years older at time surgery; (3) follow up least 12...

Abstract Purpose This study investigates the redislocation rate and functional outcome at a minimum follow-up of five years after medial patellofemoral ligament (MPFL) reconstruction with soft tissue patellar fixation for patella instability. Methods Patients were retrospectively identified knees evaluated trochlea dysplasia according to Dejour, presence alta cartilage lesion surgery. At years, information about an incident was obtained. Kujala, Lysholm, Tegner questionnaires as well range...