A5004469151- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Alkaline Phosphatase Research Studies
- Bone health and osteoporosis research
- Bone health and treatments
- Orthopedic Infections and Treatments
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Hip disorders and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Disease Management Strategies
- Heterotopic Ossification and Related Conditions
- Knee injuries and reconstruction techniques
- Biochemical and Molecular Research
- Hip and Femur Fractures
- PI3K/AKT/mTOR signaling in cancer
- Electrolyte and hormonal disorders
- Trauma and Emergency Care Studies
- Patient-Provider Communication in Healthcare
- Medical Imaging and Pathology Studies
- Digestive system and related health
- COVID-19 and healthcare impacts
University of Würzburg
2020-2025
Klinik König-Ludwig Haus
2019-2025
In adult hypophosphatasia (HPP) patients, elevated lumbar spine dual X-ray absorptiometry (DXA) values are associated with markers of disease severity and disease-specific fracture risk while femoral bone mineral density (BMD), being largely unaffected by the severity, may still be useful to monitor other causes increased due low BMD.Hypophosphatasia is a rare inherited metabolic disorder deficient activity tissue-nonspecific alkaline phosphatase (TNAP). Clinical manifestation in HPP...
In total knee arthroplasty (TKA), functional phenotypes are of interest regarding surgical alignment strategies. Functional were introduced in 2019 and consist limb, femoral, tibial phenotypes. The hypothesis this study was that mechanically aligned (MA) TKA changes preoperative phenotypes, which decreases the 1-year Forgotten Joint (FJS) Oxford Knee Score (OKS) increases WOMAC. All patients included had end-stage osteoarthritis treated with a primary MA TKA, supervised by four academic...
Hypophosphatasia (HPP) is a rare, inherited, metabolic disease characterized by tissue-nonspecific alkaline phosphatase deficiency resulting in musculoskeletal and systemic clinical manifestations. This observational study evaluated the effectiveness of enzyme replacement therapy with asfotase alfa on physical function health-related quality life (HRQoL) among adults pediatric-onset HPP who received for 12 months at single center (ClinicalTrial.gov no.: NCT03418389). Primary outcomes...
In March 2020, Germany imposed a nationwide lockdown to curb the spread of COVID-19, prompting questions about impact on incidence common fractures. This study examined 15 fracture types in pre-outbreak (2010-2019) and post-outbreak (2020-2021) periods, using data categorized by age (18-64 years, >65 years) sex (male, female). Linear regression assessed annual growth rates, mean numbers were compared across periods for significant differences. Results indicated positive correlation between...
There is limited understanding of how asfotase alfa affects mineral metabolism and bone turnover in adults with pediatric-onset hypophosphatasia. This study showed that hypophosphatasia treated experienced significant changes biochemical markers metabolism, possibly reflecting enhanced remodeling previously osteomalacic bone. Hypophosphatasia (HPP), due to a tissue nonspecific alkaline phosphatase (TNSALP) deficiency, can cause impaired mineralization turnover. Although HPP may be alfa, an...
The present study of total knee arthroplasty (TKA) describes an intra-operative method that determines the direction and quantifies magnitude deviation distal posterior medial lateral (DM, PM, DL, PL) condyle femoral component relative to pre-arthritic articular surface. For each condyle, deviations were categorized, analysis determined which had better or worse Forgotten Joint Score (FJS), Oxford Knee (OKS), WOMAC scores at 1-year follow-up.Four academic surgeons supervised a cemented...
Direct anterior approach total hip replacement (DAA-THR) is gaining increased interest due to its tissue-sparing nature and rapid recovery. Obesity has been shown be a significant parameter influencing cup positioning in DAA-THR. It was the intention of this retrospective study examine how obesity would influence restoration native biomechanical parameters during A 74 patients from high-volume university orthopedic center after unilateral DAA-THA were included. Patients retrospectively...
Rapidly destructive osteoarthritis (RDO) of the hip joint is characterised by rapid destruction femoral head with or without acetabular involvement. There has been increasing interest in this disease over past years; however, entity still poorly understood, and its pathophysiology remains unknown. Yet, there ample evidence today that increased bone metabolism might play a role onset progression disease. Vitamin D utmost importance to maintain balanced metabolism. However, whether vitamin...
Background: Traumatic compartment syndrome is a critical condition that can lead to severe, lifelong disability. Methods: This retrospective study analyzed hospital billing data from 2015 2022, provided by the Federal Statistical Office of Germany, examine demographics and trends traumatic in Germany. The analysis included cases coded with ICD-10 codes T79.60 T79.69 any therapeutic OPS code starting 5-79, focusing on diagnosis year, gender, code, patient age. Results: results showed out...
Zusammenfassung Die Untersuchung des Stellenwerts von Supplementen und Mangelvermeidung im Rahmen der Ernährung bei Osteoporose rückt zunehmend in den Interessenmittelpunkt. Gleichzeitig basiert die Wissenschaft zu diesem Thema überwiegend auf Observationsstudien während genaue Erforschung Kausalzusammenhängen Dosis-Wirkungsbeziehungen eine Herausforderung bleibt. Insbesondere Datenlage zur Wertigkeit einer Proteinsupplementation, sowie gezielten Zufuhr Folsäure, Vitamin B6 B12, Kalium...
Several studies have reported a high prevalence of hypovitaminosis D in orthopedic patients. The purpose this prospective observational study was to report on the patients scheduled for elective primary total knee arthroplasty (TKA) and its associated risk factors.
Sarcopenia and malnutrition are important determinants of increased fracture risk in osteoporosis. SARC-F MNA-SF well-established questionnaires for identifying patients at these conditions. We sought to evaluate the feasibility potential added benefit such assessments as well actual prevalence conditions osteoporosis patients. conducted a cross-sectional, single-center study female ≥ 65 years (SaNSiBaR-study). Results sarcopenia (SARC-F) (MNA-SF) screening were matched with functional...
Inpatient rehabilitation (IR) is a common postoperative protocol after total knee replacement (TKA). Because IR expensive and should therefore be justified, this study determined the difference in function one year TKA patients treated with or outpatient rehabilitation, fast-track (FTR) particular, which also entails reduced hospital length of stay. A 205 were included multi-center prospective cohort study. Of patients, 104 had primary at German university received IR, while 101 Canadian...
Einleitung Die Tumor-induzierte Osteomalazie (TIO) ist ein seltenes, paraneoplastisches Syndrom aufgrund eines meist gutartigen phosphaturischen mesenchynalen Tumors (PMT). Tumoren verursachen durch die Sekretion von Fibroblast-Growth-Factor 23 (FGF23) einen renalen Phosphatverlust und eine defiziente Aktivierung Vitamin D. Das Krankheitsbild gekennzeichnet muskuläre Schwäche, Knochenschmerzen multiplen Frakturen. Goldstandard in der Diagnostik sind das DOTATOC oder DOTATATE-PET-CT, womit...
Total hip arthroplasty (THA) is commonly performed using off-the-shelf implants. In the case of a severe mismatch between anatomy proximal femur and geometry stem, use custom-made stems might become necessary. The goal this study was to investigate precision implantation one manufacturer (CTX AQ Implants) determine risk factors for malpositioning. All patients receiving CTX stem 2014 2020 at six high-volume academic centers were retrospectively recruited. achieved position as determined by...
Zusammenfassung Bei der X-chromosomalen Hypophosphatämischen Rachitis (XLH) handelt es sich um eine seltene, aber mit einer Prävalenz von 1 : 20 000 gleichzeitig die häufigste genetisch bedingte Phosphatverlusterkrankung. Ursächlich sind Veränderungen im PHEX-Gen (Phosphate Regulating Endopeptidase Homolog, X-linked) auf dem X-Chromosom. Die Mutationen führen zu Störung Metabolisierung des vorwiegend Osteozyten sezernierten FGF-23 und bedingen über Verminderung Natrium-Phosphat Co-...
Bei der Hypophosphatasie handelt es sich um eine seltene, genetisch determinierte Erkrankung, verursacht durch Mutation im ALPL-Gen. Erwachsene Patienten mit zeigen ein breites Spektrum verschiedener Symptome, häufig wird in diesem Zusammenhang auch erhöhtes Frakturrisiko beobachtet. Dennoch ist bis heute unklar, ob und welchem Rahmen die Knochendichte bei generell verändert dieser Parameter zur Beurteilung des Frakturrisikos erwachsenen heranziehen lässt. Das Ziel folgenden Erhebung war es,...