A5101698383- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Turtle Biology and Conservation
- Reproductive biology and impacts on aquatic species
- Gender Studies in Language
- Animal Behavior and Reproduction
- RNA modifications and cancer
- Estrogen and related hormone effects
- Aquaculture disease management and microbiota
- Bone Tissue Engineering Materials
- Pancreatic function and diabetes
- Meat and Animal Product Quality
- Amphibian and Reptile Biology
- COVID-19 impact on air quality
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- 3D Printing in Biomedical Research
- Animal Genetics and Reproduction
- Sexual Differentiation and Disorders
- Genetic diversity and population structure
- Bee Products Chemical Analysis
- Plant Disease Resistance and Genetics
- Cellular Mechanics and Interactions
- Wnt/β-catenin signaling in development and cancer
- Vagus Nerve Stimulation Research
- Aquaculture Nutrition and Growth
Chinese Academy of Fishery Sciences
2020-2025
First Hospital of Jilin University
2019-2020
Jilin University
2019-2020
Wenzhou Medical University
2019
Ocean University of China
2009-2010
Kurume University
1991
Embryos of most fish develop externally and are exposed to an aquatic environment full potential pathogens, whereas they have little or only limited ability mount efficient protective response. How embryos survive pathogenic attacks remains poorly defined. Here we demonstrate that the maternal immunization female zebrafish with formalin-killed Aeromonas hydrophila causes a significant increase in C3 Bf contents mother, corresponding rise offspring, induces remarkable hemolytic activities...
The Chinese soft-shelled turtle (Pelodiscus sinensis) demonstrates noteworthy sexual dimorphism, where the males grow more rapidly and significantly larger than females under equivalent conditions. Estradiol (E2) administration can catalyze transformation from male to pseudo-female (PF), during which m6A RNA methylation undergoes considerable alterations. Nevertheless, function of methylation, specifically, methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit gene...
Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, prediabetes. A strong positive correlation between consumption diabetic incidence is revealed, but the underlying mechanisms remain obscure. Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological variability in rats, can lead to β-cells gaining memory reactive oxygen species (ROS) stress. This stress leads...
The Chinese soft-shelled turtle (Pelodiscus sinensis) exhibits sexual dimorphism. Compared with females, males are considered to have higher economic value due their accelerated growth, greater body mass, and longer skirt width. Studies focused on these sex disparities largely neglected potential differences in growth. Here, we performed RNA sequencing of muscle tissue components from 1-year-old specimens reveal gene expression patterns P. sinensis. In our male female cohorts, analysis...
This experiment aimed to assess the impact of different dietary curcumin (CM) levels on growth, muscle quality, serum-biochemical parameters, antioxidant-enzyme activities, gut microbiome, and liver transcriptome in Chinese soft-shelled turtles (Pelodiscus sinensis). Five experimental diets were formulated include graded at 0 (control, CM0), 0.5 (CM0.5), 1 (CM1), 2 (CM2) 4 g/kg (CM4). Each diet was randomly distributed quadruplicate groups (164.33 ± 5.5 g) for 6 weeks. Our findings indicated...
The Chinese soft-shelled (Pelodiscus sinensis) turtle exhibits obvious sex dimorphism, which leads to the higher economic and nutritional value of male individuals. Exogenous hormones can cause transformation from female phenotype during gonadal differentiation. However, molecular mechanism related sexual reversal process is unclear. In this study, we compared difference between small RNAs male, female, pseudo-female turtles by RNA-seq understand turtles. A certain dose estrogen are called...
The Chinese soft-shelled turtle Pelodiscus sinensis, an economically important species in China, exhibits significant sexual dimorphism. Males are more valuable than females owing to their wider calipash and faster growth. Estradiol (E2)-induced sex reversal is used achieve all-male breeding of turtles; however, the mechanism this remains unclear. In study, we characterized Sox3 gene, whose expression level was high gonads brain exhibited dimorphism ovary. During embryonic development,...
The effect of acupuncture points stimulation on the induction plaque-forming cells (PFC) in spleen BALB/c mice was investigated vivo and vitro tests. In experiment, were immunized with 2 x 10(8) sheep red blood (SRBC) PFC markedly increased by daily (once a day for 4 days) stimulation. enhancement completely blocked preadministration procain, hexamethonium, naloxone, propranolol, but not phentolamine. also observed non-immunoized when acupunctured cultured SRB vitro. after acupuncture,...
Chinese soft-shelled turtles display obvious sex dimorphism. The exogenous application of hormones (estradiol and methyltestosterone) can change the direction gonadal differentiation P. sinensis to produce reversed individuals. However, molecular mechanism remains unclear. In this study, TMT-based quantitative proteomics analysis four types (female, male, pseudo-female, pseudo-male) gonads were compared. Quantitative 6107 labeled proteins in was performed. We identified 440 downregulated 423...
Sex dimorphism is a key feature of Chinese soft-shelled turtle (Pelodiscus sinensis). The males (M) have higher econosmic value than females (F) due to wider calipash and faster growth. Exogenous hormones like estradiol methyltestosterone can induce sexual reversal form new phenotypes (pseudo-female, PF; pseudo-male, PM) without changing the genotype. possibility inducing particularly important in aquaculture breeding, but underlying biological mechanisms remain unclear. Here we applied...
The Chinese soft-shelled turtle (Pelodiscus sinensis), an economically important aquatic species in China, displays considerable sexual dimorphism: the male P. sinensis is larger and, thus, more popular market. In this study, we obtained full-length (FL) transcriptome data of by using Pacific Biosciences (PacBio)’s isoform sequencing and analyzed structure. total, 1,536,849 high-quality FL transcripts were through single-molecule real-time (SMRT) sequencing, which then corrected Illumina...
Gingival overgrowth (GO) includes gingival enlargement and hyperplasia may be induced by certain drugs, including calcium channel blockers (CCBs), particularly first-generation CCBs. However, to date, only few cases of GO second- or third-generation CCBs have been reported. The present study reports on a case 48-year-old diabetic male who was admitted the First Hospital Jilin University (Changchun, China) due poor blood glucose control. This patient diagnosed with GO. Review patient's...
Among Chinese soft-shelled turtles, Pelodiscus sinensis, males have a richer nutritional value and higher market price than females. All-male offspring were obtained by 17β-estradiol (E2). However, the molecular mechanisms of E2 inducing sexual reversal remain unclear. In this study, we cloned estrogen nuclear receptors (ERs) from P. sinensis investigated their expression profiles. We examined responses ERα ERβ after treatment with different concentrations 1.0, 5.0, 10 mg/mL E2. ERs showed...
The Chinese soft-shelled turtle (Pelodiscus sinensis) is an important freshwater aquaculture animal in China. Wnt gene family plays regulatory roles the development and growth of mammals. However, precise function these genes has not been well understood sex differentiation turtles. Here, we cloned a member family, Wnt2, which obtained 1077 bp open reading frame that encoded 358-aa protein. putative amino acid sequences proteins are exceeded 80% identical to other expression level Wnt2...
The Chinese soft-shelled turtle, Pelodiscus sinensis, is an important aquaculture species in China that exhibits distinct sexual dimorphism; male individuals are economically more valuable than females. In vertebrates, several R-spondin family proteins have been associated with sex differentiation mechanisms; however, their involvement P. sinensis unclear. Exogenous hormones such as estradiol (E2) also influence the of and induce reversal. present study, we investigated effects E2 on...