A5031892176- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Psychosomatic Disorders and Their Treatments
- Personality Disorders and Psychopathology
- Neurotransmitter Receptor Influence on Behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience and Neuropharmacology Research
- Digital Mental Health Interventions
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- Posttraumatic Stress Disorder Research
- Impact of Technology on Adolescents
- Tryptophan and brain disorders
Altrecht GGZ
2016-2025
Utrecht University
2015-2021
Royal Netherlands Academy of Arts and Sciences
2017
University of Amsterdam
2017
GGZ inGeest
2017
Netherlands Institute for Neuroscience
2017
Introduction The construct of epistemic trust (ET) has gained wide acceptance and support in the field, although there is little empirical evidence to substantiate theoretical assumed model. Studies assessment ET were conducted community samples only mediating role attachment mentalizing addition was not investigated. This study examines relationships between as well attachment, association childhood adversity borderline personality disorder (BPD) a heterogeneous sample containing also...
Preclinical research suggests that enhancing CB1 receptor agonism may improve fear extinction. In order to translate this knowledge into a clinical application we examined whether cannabidiol (CBD), hydrolysis inhibitor of the endogenous agonist anandamide (AEA), would enhance effects exposure therapy in treatment refractory patients with anxiety disorders. Patients panic disorder agoraphobia or social were recruited for double-blind parallel randomised controlled trial at three mental...
Early childhood adversity may dispose an individual to adopt a rigid and pervasive hypervigilant position toward information coming from others, resulting in high levels of epistemic mistrust (EM), which is supposed increase the risk developing psychopathology. A more intrinsic relationship between EM development personality disorders (PDs) assumed. Although theory trust (ET) rather novel, it has quickly become widely accepted field, despite much empirical evidence. This first study...
Explicit instructions regarding stimulus-threat associations increase acquisition and extinction of fear in healthy participants. The current study aimed to investigate the effect contingency on patients with anxiety disorders. Patients various disorders (N = 104) comparison participants 93) participated a differential conditioning task (within-subjects design). Approximately halfway through phase, were instructed about association, approximately informed that unconditioned stimulus (US)...
Recent meta-analyses indicated differences in fear acquisition and extinction between patients with anxiety-related disorders comparison subjects. However, these effects are small may hold for only a subsample of patients. To investigate individual trajectories across (N = 104; before treatment) subjects 93), data from previous study (Duits et al., 2017) were re-analyzed using data-driven latent class growth analyses. In this explorative study, subjective ratings, shock expectancy ratings...
Phobic anxiety disorders are among the most prevalent psychiatric and burdensome in terms of loss quality life work productivity. Evidence-based treatments relatively successful majority patients, especially exposure therapy. However, a substantial subset patients fails to achieve or stay remission. Preclinical genetic research have yielded evidence that cannabinoid system is involved extinction fear, presumed underlie beneficial effects therapy phobic disorders. A constituent may enhance...
D-cycloserine (DCS) is a partial N-methyl-D-aspartate receptor agonist that potentially augments response to exposure therapy in anxiety disorders by enhancing extinction learning. This randomized, double-blinded, placebo-controlled augmentation trial examined (1) the effectiveness of adding 125 mg DCS (before or directly after first 6 treatment sessions) patients with panic disorder agoraphobia and (2) preceding relative postexposure.Fifty-seven were allocated 1 3 medication conditions...
Studies on the development and treatment of anxiety disorders mostly focus comparison predefined groups. An alternative approach is to use data-driven latent class growth analyses (LCGA) determine differentiation between groups based particular mechanistic factors. This study validated LCGA responses in a compact fear conditioning task whether specific characteristics are associated with maladaptive learning trajectories.Healthy subjects (N = 300) completed that included uninstructed...
Although impaired fear extinction has repeatedly been demonstrated in patients with anxiety disorders, little is known about whether these impairments persist after treatment. The current comparative exploratory study investigated 26 treated for their disorder the years preceding as compared to 17 healthy control subjects. Fear-potentiated startle and subjective were measured a cue context conditioning paradigm within virtual reality environment. Results indicated no differences between...
Exposure-based therapy is the treatment of choice for anxiety disorders, but many patients do not benefit sufficiently from it. Distressing images threat related to future or past may maintain symptomatology impede exposure therapy. An intervention that targets threat-related imagery eye movement desensitization and reprocessing (EMDR) The main goal this multicenter randomized controlled trial investigate whether EMDR plus therapy, relative supportive counseling improves efficacy,...