A5053259724- Congenital heart defects research
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Coronary Artery Anomalies
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Congenital Heart Disease Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- COVID-19 and Mental Health
- Personality Disorders and Psychopathology
- Reading and Literacy Development
- Body Image and Dysmorphia Studies
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Family and Disability Support Research
- Cognitive and developmental aspects of mathematical skills
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Hearing Impairment and Communication
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Sapienza University of Rome
2012-2020
University of Padua
2020
University of Rome Tor Vergata
2019
Università Cattolica del Sacro Cuore
2016
Office Médico Pédagogique
2016
University of Geneva
2016
Creative Research Enterprises (United States)
2016
Fondazione Santa Lucia
2012-2014
Down's syndrome (DS) is the most frequent genetic cause of intellectual disability and patients with DS show significant psychopathology (18-23%). Moreover, individuals often a cognitive decline associated ageing characterized by deterioration in memory, language functioning. According to these relevant findings, an overview presented state-of-the-art knowledge neurocognitive, neurobiological psychopathological profile, assessment treatment DS. The linguistic characteristics develop...
In this study, we examined the effect of multiple versus single stimulus presentation in typically developing readers and children with developmental dyslexia. The tasks involved either reading words or arrays naming colors digits (rapid automatized RAN). To be able to compare these sets conditions, recorded total response times (i.e., time between onset end participant's vocal response) all cases. study included 43 25 Results indicate that have a clear advantage over items on both RAN...
The 22q11.2 deletion syndrome (22q11DS) is characterized by high rates of psychotic symptoms and schizophrenia, making this condition a promising human model for studying risk factors psychosis. We explored the predictive value ultra (UHR) criteria in sample patients with 22q11DS. also examined additional contribution socio-demographic, clinical cognitive variables to predict transition psychosis within mean interval 32.5 ± 17.6 months after initial assessment. Eighty-nine participants...
Nearly one-third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder during life, most them by early adulthood. Importantly, full-blown episode is usually preceded subthreshold symptoms. In the current study, 760 participants (aged 6–55 years) confirmed hemizygous microdeletion have been recruited through 10 medical sites worldwide, as part an international research consortium. Of them, 692 were nonpsychotic and complete measurement data. Subthreshold...
The 22q11.2 deletion syndrome is caused by non‐allelic homologous recombination events during meiosis between low copy repeats (LCR22) termed A, B, C, and D. Most patients have a typical LCR22A‐D (AD) of 3 million base pairs (Mb). In this report, we evaluated IQ scores in 1,478 subjects with 22q11.2DS. mean full scale IQ, verbal performance our cohort were 72.41 (standard deviation‐ SD 13.72), 75.91( 14.46), 73.01( 13.71), respectively. To investigate whether are associated size, examined...
Abstract Antipsychotics are the most widely used medications for treatment of schizophrenia spectrum disorders. While such drugs generally ameliorate positive symptoms, clinical responses highly variable in terms negative symptoms and cognitive impairments. However, predictors individual have been elusive. Here, we report a pharmacogenetic interaction related to core dysfunction patients with schizophrenia. We show that genetic variations reducing dysbindin-1 expression can identify...
The aim of the study was to explore clinical significance school refusal behavior, its negative impact on psychological well-being children and adolescents relationship with most common psychopathological conditions during childhood adolescence (e.g. neurodevelopmental disorders, psychiatric disorders). School behavior refers a distressing condition experienced by that compromise regular attendance determine consequences mental health adaptive functioning. A narrative review literature...
In reading aloud, the eye typically leads over voice position. present study, movements and utterances were simultaneously recorded tracked during of a meaningful text to evaluate eye-voice lead in 16 dyslexic same-age control readers. Dyslexic children slower than peers texts. Their slowness was characterized by great number silent pauses sounding-out behaviors small lengthening word articulation times. Regarding movements, readers made many more fixations (and generally smaller rightward...
Autism Spectrum Disorder (ASD) affects millions of individuals worldwide, presenting challenges in social communication, repetitive behaviors, and sensory processing. Despite its prevalence, diagnosis can be lengthy, access to appropriate treatment varies greatly. This project utilizes the power Artificial Intelligence (AI), particularly Machine Learning (ML) Deep (DL), improve treatment. A central data hub, Master Data Plan (MDP), will aggregate analyze information from diverse sources,...
Anxiety disorders (ADs) are common among children and adolescents frequently co-occur with specific learning disorder (SLD). Approximately 20% of SLD meet criteria for ADs, while those anxiety six times more likely to have a premorbid SLD. The strong relationship between ADs underscores the importance examining developmental trajectories manifestations neuropsychiatric conditions like particularly when is present. In this context, study investigates clinical profiles first diagnosis an AD...
Despite evidence suggesting increased rates of psychosis in individuals with autism spectrum disorder (ASD), the detection prodromal psychotic symptoms, including attenuated syndrome (APS), remains underexplored this population. The primary aim present study was to characterize clinical phenotype young ASD who also APS (ASD/APS; n = 48) comparison only (n 93) and those 30) (age range 9-23 years). Assessments included standardized measures autistic symptoms (Autism Diagnostic Observation...
Abstract The catechol- o -methyltransferase ( COMT ) genetic variations produce pleiotropic behavioral/neuroanatomical effects. Some of these effects may vary among sexes. However, the developmental trajectories -by-sex interactions are unclear. Here we found that extreme reduction, in both humans (22q11.2 deletion syndrome Met) and mice −/−), was associated to cortical thinning only after puberty females. Molecular biomarkers, such as tyrosine hydroxylase, Akt neuronal/cellular counting,...
Aims: Recent meta-analytic data show that approximately 40% of individuals at clinical high risk for psychosis (CHR) receive least one personality disorder (PD) diagnosis. Personality pathology could significantly influence CHR patients' prognosis and response to treatment. We aimed exploring the PD traits adolescents, in order outline a prototypic description their most frequently observed characteristics. Methods: One hundred twenty-three psychiatrists psychologists used Q-sort procedure...
Abstract To be relevant to healthcare systems, the clinical high risk for psychosis (CHR-P) concept should denote a specific (i.e., unique) population and provide useful information guide choice of intervention. The current study applied network analyses examine specificities CHR-P youths compared general help-seekers non–CHR-P youth. 146 (mean age = 14.32 years) 103 12.58 help-seeking youth were recruited from neuropsychiatric unit assessed using Structured Interview Psychosis-Risk...