A5101404225- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Erythrocyte Function and Pathophysiology
- Exercise and Physiological Responses
- Salivary Gland Tumors Diagnosis and Treatment
- Biosensors and Analytical Detection
- NF-κB Signaling Pathways
- Nail Diseases and Treatments
- Ocular Surface and Contact Lens
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Nuts composition and effects
- Tumors and Oncological Cases
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
- Ear and Head Tumors
- Ottoman and Turkish Studies
- Inhalation and Respiratory Drug Delivery
- Celiac Disease Research and Management
Kayseri Eğitim ve Araştırma Hastanesi
2013-2024
Sağlık Bilimleri Üniversitesi
2024
State Hospital
2019
Erciyes University
2012-2016
Pediatrics and Genetics
2013
Abstract Background Artemis deficiency is an autosomal recessive disorder characterized by a combined immunodeficiency with increased cellular radiosensitivity. In this review, the clinical and genetic characteristics of 15 patients DCLRE1C variants are presented. Methods The demographic, clinical, immunologic, confirmed diagnosed between 2013 2023 were collected retrospectively. Three evaluated for radiosensitivity Comet assay, compared age‐ sex‐matched healthy control. Results Seven who...
Primary immunodeficiency diseases (PIDs) are a heterogeneous group of disorders that genetically affect distinct components the immune system; thus, predispose individuals to recurrent infections, allergy, autoimmunity, and malignancies. In this retrospective study, autoimmune (ADs), which developed during course PID in children, were discussed.Twenty-five patients included study. Symptoms related ADs, such as thyroiditis, type 1 diabetes mellitus, coeliac disease, juvenile idiopathic...
Symptomatic dermographism (SD) is the most common form of chronic inducible urticaria. SD disease activity increases with food intake in adult patients. Whether this also so children currently unknown.
Patients with hyperimmunoglobulin E syndrome (HIES) and chronic granulomatous disease (CGD) have prominently increased immunoglobulin (Ig) levels. We present a 9-year-old boy medical history revealing recurrent pneumonia, suppurative lymphadenitis, diarrhea, otitis. The patient was hospitalized severe pneumonia. examination showed tachypnea, crackles at the right left base of lung, freckles on his face, red-hair, gingivitis, high arched palate, retained primary dentition. Serum IgE level...
Increased numbers of mast cells that contain tryptase are found in lesional atopic dermatitis (AD) skin. The association serum basal (sBT) with anaphylactic reactions and cell diseases has recently been shown children venom food allergy.We aimed to identify the risk factors predict severity AD sBT levels disease severity.AD diagnosis was made according Hanifin Rajka criteria. Disease scored by objective scoring (SCORAD) index. were measured. Skin-prick testing, total immunoglobulin E,...
Forced expiratory flow between 25% and 75% of vital capacity (FEF25-75%), a spirometric measure small airways, may predict the presence airway responsiveness both in asthmatics allergic rhinitis (AR). We aimed to search correlation FEF25-75% standard measures spirometry (forced volume first second [FEV1%] FEV1/FVC [forced capacity]) different clinical conditions, that is children with asthma, asthma AR, AR healthy children.Children (N.=116), plus (N.=25), (N.=75) controls (N.=52) were...
Myeloperoxidase (MPO) deficiency is one of the most common inherited phagocyte defects, but it rarely associated with clinical symptoms [1]. MPO, which abundant in azurophilic granules neutrophils and lysosomes monocytes, plays a key role amplifying toxicity hydrogen peroxide generated by respiratory burst [1,2]. The diagnosis MPO was rare before 1979; currently, easily made due to widespread use automated flow cytochemical analysis hematology laboratories for enumerating peripheral blood...
Abstract Background Human leukocyte antigen ( HLA )‐G is a non‐classical major histocompatibility complex class I characterized by limited polymorphism in its coding region, unique tissue expression pattern physiologic conditions and immunomodulatory properties. Recently, the level of soluble (s) ‐G was found to be higher atopic asthma allergic rhinitis, but this remains clarified wheezy infants. The aim present study therefore investigate sHLA Methods subjects consisted infants with...
Herpes simplex virus (HSV) infections are common in childhood. It can cause different clinical pictures from orolabial infection to life-threatening disease. After the primary infection, HSV establishes life-long latency neurons of sensory ganglia and usually reactivates at initial site entry. Recurrent troubling affect patient's quality life (Glitter JK et al. Pediatr Dermatol 2017; 34: 446–449, Pittet LF Rev Med Virol 2021; 31: 1–9, Harrison in:Textbook Pediatric Infectious Diseases 2019:...
Objective: Deficiency of the purine salvage enzymes adenosine deaminase (ADA) or nucleoside phosphorylase (PNP) leads to severe combined immune deficiency (SCID). Since these are found in all cells, other tissues and organs also affected, though more variably. Materials Methods: Here we describe clinical course treatment one PNP deficient 4 ADA patients who were diagnosed infancy. All had very low T-cell count immunoglobulins, consistent with T-B-NK- SCID. Results: Hematopoietic stem cell...
Background: Some patients with severe combined immunodeficiency may have normal T-cell counts a immune-cell activation defect in complex signaling that regulates transcriptional programs. The nuclear factor κB (NF-κB) pathway plays role inflammatory and immune responses, cell adhesion, protection against apoptosis. NF-κB requires degradation of the inhibitor (IκB) proteins initiated by their phosphorylation IκB kinase (IKK) consisting two active kinases, IKKα IKKβ. links these transcription...
OZET oksidaz enziminin gp91phox alt unitesini kodlayan CCYB genindeki hata sonucu olusurken, otozomal cekinik gecisli KGH ise enzim kompleksinin p22phox, p47phox, p67phox ya da p40phox birimini sirasiyla CYBA, NCF-1, NCF-2 ve NCF-4 genlerinde meydana gelen olusur (2). Bu calisma ile merkezimizde tanisi izlenen olgularin klinik tablolari, laboratuar bulgulari genetik ozelliklerinin belirlenmesi amaclandi.