A5062943852- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Neonatal Health and Biochemistry
- Glioma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Neutropenia and Cancer Infections
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Methemoglobinemia and Tumor Lysis Syndrome
- Acute Kidney Injury Research
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cancer therapeutics and mechanisms
- Pharmaceutical studies and practices
- Vascular Malformations and Hemangiomas
- Poisoning and overdose treatments
Prince of Songkla University
2015-2024
Songklanagarind Hospital
2012-2017
St. Jude Children's Research Hospital
2008-2010
Abstract Background Southeast Asia is undergoing a transition from infectious to chronic diseases, including dramatic increase in adult cancers. Childhood cancer research Thailand has focused predominantly on leukemias and lymphomas or only examined children for short period of time. This comprehensive multisite study childhood incidence survival rates across all International Classification Cancer (ICCC) groups over 20‐year period. Methods cases diagnosed ages 0‐19 years ( n = 3574) 1990...
Hyperleukocytosis and extreme hyperleukocytosis, defined as initial white blood cell counts greater than 100 × 109/L 200 109/L, respectively, have been associated with unfavorable outcomes. This study aimed to determine the early complications survival outcomes of childhood leukemia patients hyperleukocytosis. The medical records 690 children newly diagnosed acute between January 1998 December 2017 were retrospectively reviewed. Kaplan-Meier method log-rank test used assess compare...
Objective: This study aimed to examine the prognostic factors and treatment outcomes of patients with acute leukemia aged under 2 years. Material methods: The medical records between January 1979 December 2021 were retrospectively reviewed. Kaplan-Meier method was used calculate event-free survival (EFS) overall (OS) rates. A univariate Cox proportional hazards regression model identify clinical associated poor EFS OS. p-value<0.05 considered statistically significant.Results: Over...
Background Cardiac and liver iron assessment using magnetic resonance imaging (MRI) is non-invasive used as a preclinical “endpoint” in asymptomatic patients for serial measurements iron-overloaded patients. Purpose To compare between hepatic myocardial T2* T2 at 1.5T 3T MRI normal Material Methods The values from the regions of interest (ROIs) mid-left ventricle mid-hepatic slices were evaluated by scans healthy Results For patients, (1.5T) (3T) 60.3 ms (range = 56.2–64.8 ms) 55 51.6–60.1...
<br><b>Background:</b> The current prognosis of medulloblastoma in children is better because technological advancements and improvements treatment strategies genetic investigations. However, there a lack studies that focus on Thailand. aims our study were to conduct survival analysis identify the prognostic factors pediatric medulloblastoma. <b>Materials Methods:</b> Fifty-five children, with medulloblastoma, eligible for between 1991 2015. We retrospectively reviewed both clinical...
Abstract Background Prognosis of low-grade glioma are currently determined by genetic markers that limited in some countries. This study aimed to use clinical parameters develop a nomogram predict survival patients with diffuse astrocytoma (DA) which is the most common type glioma. Materials and Methods Retrospective data adult DA from three university hospitals Thailand were analyzed. Collected included characteristics, neuroimaging findings, treatment, outcomes. Cox’s regression analyses...
Iron overload has not been studied extensively and prospectively in pediatric survivors of allogeneic hematopoietic stem cell transplantation (HSCT); therefore, we conducted a prospective long-term study 133 childhood leukemia to assess the incidence risk factors for iron investigate its association with organ dysfunction. One yr after HSCT, mean serum ferritin level was 1158 ng/mL (range, 22-3264 ng/mL), 124 patients (93.2%) having that exceeded upper limit normal range (110 ng/mL)....
NK cells play an important role in hematopoietic stem cell transplantation (HCT) and cross talk with dendritic (DCs) to induce primary T response against infection. Therefore, we hypothesized that blood DCs should augment function reduce the risk of leukemia relapse after HCT. To test this hypothesis, conducted laboratory clinical studies parallel. We found although, phenotypically, could DC maturation turn increase activating marker expression on cells, paradoxically, both BDCA1(+) myeloid...
Abstract Background Children with red blood cell disorders may receive regular transfusions from an early age and consequently accumulate iron. Adequate iron chelation therapy can prevent organ damage delayed growth/development. Deferasirox is indicated for treatment of pediatric patients chronic overload due to transfusional hemosiderosis; however, fewer than 10% in the registration studies were aged 2 less 6 years. Procedure Deferasirox, a once‐daily oral chelator, was evaluated young...
Background: In recent decades, the prognosis for childhood leukemia has improved, especially acute lymphoblastic (ALL). Thailand, though, survival rate ALL is unimpressive. 2006, standard national protocols treatment were implemented. We herein report outcome of and explanations behind discrepancies in outcomes between institutions. Materials Methods: Between March 2006 February 2008, 486 children with from 12 institutions enrolled Thai protocols. There 3 different based on specific...
Genomic-based tools have been used to predict poor prognosis high-grade glioma (HGG). As genetic technologies are not generally available in countries with limited resources, clinical parameters may be still necessary use predicting the of disease. This study aimed identify prognostic factors associated survival patients HGG. We also proposed a validated nomogram using HGG.A multicenter retrospective was conducted who were diagnosed anaplastic astrocytoma (WHO III) or glioblastoma IV)....
Acquired platelet dysfunction with eosinophilia (APDE) is a syndrome which manifests as transient state of in the presence eosinophilia. The aim this work was to study clinical course and outcomes children diagnosed APDE. hospital records APDE were retrospectively reviewed total 69 included. mean (standard deviation) age at diagnosis 6.9 (3.1) years. All patients presented ecchymoses on extremities, body, face. None had serious bleeding symptoms. Platelet counts within normal range but all...
We report 2 cases of accidental intrathecal vincristine administration. These injections were scheduled as intravenous at the same time other drugs scheduled. The mistakes recognized immediately after administration, and a lumbar puncture was performed to lavage cerebrospinal fluid (CSF) incident. However, both developed progressive sensorimotor radiculo-myelo-encephalopathy patients died 3 6 days incidents due decerebration. A number administration have occurred in recent years settings, we...
Wilms tumor (WT), the most prevalent type of renal cancer in children, exhibits overall survival rates exceeding 90%. However, chemotherapy resistance, which occurs approximately 10% WT cases, is a major challenge for treatment WT, particularly advanced-stage patients. In this study, we aimed to discover potential mutation markers and drug targets associated with resistance WT. We performed exome sequencing detect somatic mutations molecular 43 samples, comprising 26 WTs, 7 cases were...
Abstract Background Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed use of topotecan and cyclophosphamide containing induction regimen as an upfront therapy to high risk neuroblastoma patients. Methods Patients undergoing ThaiPOG protocol from 2016 2017 were studied. All received 6 cycles consisting 2 (1.2 mg/m /day) (400 for 5 days followed by cisplatin...
Abstract Background Initial clinical factors that can reliably predict a successful within‐1‐year resolution of childhood immune thrombocytopenia (ITP) are still unclear. This study aimed to determine associated with within‐12‐month newly diagnosed ITP. Methods The hospital records 417 consecutive children aged less than 15 years ITP were reviewed retrospectively and data related the initial presentation noted. Logistic regression analysis was used which presenting features favorable outcome...
Abstract Background Childhood leukemia with musculoskeletal (MSK) involvement mimics various conditions, which consequently leads to diagnostic delays. The clinical implication of MSK in this disease on survival outcomes is inconclusive. This study aimed compare characteristics and between non-MSK childhood leukemia. Methods medical records children newly diagnosed acute an age under 15 years were retrospectively reviewed. Two-to-one nearest-neighbor propensity score-matching was performed...
The outcomes of relapsed childhood acute lymphoblastic leukemia (ALL) in developed countries have improved over time as a result risk-adapted, minimal residual disease-directed therapy, hematopoietic stem cell transplantation, and immunotherapy. There are few studies that examined survival ALL resource-limited countries. Therefore, this study aimed to assess the prognostic factors outcome major tertiary center Southern Thailand.The medical records patients with aged <15 years between January...