A5039244805- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer, Hypoxia, and Metabolism
- Acute Lymphoblastic Leukemia research
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Cancer therapeutics and mechanisms
- Histiocytic Disorders and Treatments
- Bacterial Identification and Susceptibility Testing
- Vascular Malformations and Hemangiomas
- Neutropenia and Cancer Infections
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Iron Metabolism and Disorders
- Polyomavirus and related diseases
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Antibiotic Resistance in Bacteria
- Cytomegalovirus and herpesvirus research
- Ocular Oncology and Treatments
- Hemophilia Treatment and Research
Chulalongkorn University
2015-2024
King Chulalongkorn Memorial Hospital
2020-2024
Pediatrics and Genetics
2019
Baylor College of Medicine
2015-2016
Bumrungrad International Hospital
2016
Texas Children's Hospital
2015
Osteosarcoma (OS), which has a high potential for developing metastatic disease, is the most frequent malignant bone tumor in children and adolescents. Molecular analysis of genetically engineered mouse model osteosarcoma identified enhanced expression Secreted Frizzled-Related Protein 2 (sFRP2), putative regulator Wnt signaling within tumors. Subsequent correlated increased human highly OS cells. However, role sFRP2 development progression not been well elucidated. Studies using stable gain...
To determine the clinicopathologic and molecular features outcome of children with mucoepidermoid carcinoma (MEC).A retrospective analysis clinical histopathologic findings was performed in patients MEC diagnosed at Texas Children's Cancer Center between 2000 2014.Ten female four male median age 12 years (range 7-19 years) were included study. Tumors involved major salivary glands, minor glands palate, tracheobronchial tree. Nine 11 underwent more than one surgical resection time initial...
The BNT162b2 mRNA COVID-19 vaccine has been administered to children and adolescents with cancer hematologic diseases since they are at high risk of manifesting severe symptoms if have infection but the adequate immune response after vaccination in these immunocompromised patients questionable.To evaluate receiving 2 doses vaccine.This is a prospective cohort study disease, who aged 12- 18 years old received vaccines 4 weeks apart were enrolled. Immunogenicity was determined by measuring...
Molecular subtyping of medulloblastoma (MB) has become increasingly important for prognosis and management. Typically this involves detailed molecular genetic testing which may not be available in all centers. The purpose the present study was to find a simplified approach assign subtypes MB routine use centers with more limited resources. MBs from 32 Thai patients, aged 0.5 35 years, were first determined by NanoString. These results then compared those obtained using combination...
Translocations involving PLAG1 occur in several tumors, most commonly pleomorphic adenoma and lipoblastoma. Recently, a distinctive soft tissue tumor with fusion has been reported the pediatric age group. These are low grade tumors fibroblastic or mixed myxoid morphology but no other lines of differentiation. They typically immunopositive for desmin CD34. The partner genes these have included YWHAZ, EEF1A1, ZFHX4l, CHCHD7, PCMTD1. We report another case this fibromyxoid fusion, time COL3A1...
Abstract Background Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed use of topotecan and cyclophosphamide containing induction regimen as an upfront therapy to high risk neuroblastoma patients. Methods Patients undergoing ThaiPOG protocol from 2016 2017 were studied. All received 6 cycles consisting 2 (1.2 mg/m /day) (400 for 5 days followed by cisplatin...
Medulloblastoma (MB) is the most common childhood malignant brain tumor worldwide. Recently, molecular classification was established and started to play a role in management of MB; however, studies involving defined MB Southeast Asia have been limited. We aimed describe, correlate clinical characteristics subgroups with therapeutic outcomes Thai pediatric patients MB.
The germline TP53 p.R337H mutation is reported as the most common variant. It exists at a remarkably high frequency in population of southeast Brazil founder two distinct haplotypes with frequent co-segregating p.E134∗ variant XAF1 tumor suppressor and an increased cancer risk. Founder mutations demonstrate linkage disequilibrium neighboring genetic polymorphic markers that can be used to identify different geographic regions diverse populations. We report here shared haplotype among...
Transfusion-dependent thalassemia (TDT) patients require regular blood transfusions. The unavoidable consequence is iron overload. Iron chelation therapy the mainstay of treatment, which favorable outcome depends mainly on adherence level. aim this study was to assess TDT patients. A cross-sectional cohort were evaluated their using Thai version Morisky Medication Adherence Scales (MMAS-8). total 70 (38 males, 32 females), with a median age 10 years, enrolled in study. Sixteen (22.9%) and 54...
The study aimed to describe the pattern of causative microorganisms, drug susceptibility, risk factors antibiotic-resistant bacterial infection, and clinical impact these organisms on pediatric oncology patients with febrile neutropenia.A retrospective descriptive oncologic aged less than 15 years who were diagnosed neutropenia in King Chulalongkorn Memorial Hospital was conducted between January 2013 December 2017. Characteristics outcomes episodes, pathogens, their antibiotic...
Abstract Background Neuroblastoma is the most common extracranial malignant solid tumor during childhood. Despite intensified treatment, patients with high‐risk neuroblastoma (HR‐NBL) still carry a dismal prognosis. The Thai Pediatric Oncology Group (ThaiPOG) proposed use of multimodality treatment to improve outcomes HR‐NBL in non‐immunotherapy settings. Methods Patients undergoing ThaiPOG protocols (ThaiPOG‐NB‐13HR or ‐18HR) between 2013 and 2019 were retrospectively reviewed. Patient...
Intracranial germ cell tumors (IGCTs) are rare, highly curable neoplasms. KRAS is a gene in the KIT/RAS signaling pathway, and mutations have been reported patients diagnosed with IGCTs.To describe clinicopathologic molecular features of mutation treatment outcome children IGCTs.Patients IGCTs at Department Pediatrics, King Chulalongkorn Memorial Hospital from 2007 to 2016 were retrospectively reviewed. DNA was extracted formalin-fixed, paraffin-embedded tissue used for study. Mutations...
The diagnostic and treatment outcomes of intracranial germ cell tumors (ICGCTs) among low middle income countries are limited. A total 63 ICGCTs patients with a median age 11.6 years were studied. 30 (47.6%) 33 (52.4%) classified as pure germinomas nongerminomatous (NGGCTs), respectively. concordances between serum cerebrospinal fluid (CSF) alpha-fetoprotein (84.3%) beta-human chorionic gonadotropin (68.4%) addressed. 5-year overall survival (OS) event-free (EFS) rates versus NGGCTs 83.9...
The prognosis for relapsed or refractory childhood cancer is approximately 20%. Genetic alterations are one of the significant contributing factors to patients.
Background: Asparaginase is one of the essential chemotherapies used to treat acute lymphoblastic leukemia (ALL). antibody production may cause a subtherapeutic level and result in an inferior outcome. Methods: Prospective study asparaginase activity among patients who received native E.coli 10,000 IU/m2 according ThaiPOG ALL protocol. The measured by coupled enzymatic reaction. Pharmacokinetic data includeding peak (Cmax), time maximum concentration (Tmax), area under curve (AUC0-48h) being...
Disease reactivation/refractory remains a major challenge in managing Langerhans cell histiocytosis (LCH). Outcomes and late sequelae should be explored.
In our 19 years’ experience at King Chulalongkorn Memorial Hospital, we were able to observe 21 pediatric cases with anaplastic large cell lymphoma (ALCL). Of these cases, 4 (19% of ALCL cases) had concurrent hemophagocytic lymphohistiocytosis (HLH). All developed fever, lymphadenopathy and exaggerated signs capillary leakage syndrome such as generalized edema, pleural effusion or ascites. The hyperinflammation was demonstrated hypoalbuminemia elevated inflammatory markers. A high index...
Since aspirin resistance is rarely assessed in pediatric patients and thrombosis might cause damage vital organs, such as the myocardium or brain, we aimed to determine its incidence pivotal role of routine screening. The point-of-care test by platelet function analyzer (PFA-200) bedside bleeding time (BT) was compared standard whole blood impedance aggregometry (IA), time-consuming sophisticated assays. This single-center cross-sectional study investigated Thai children (≤15 years). All...
Objective: To determine the clinicopathologic features and germline tumor protein p53 (TP53) mutation in children with adrenocortical carcinoma (ACC).Material Methods: This was a retrospective study. From 2009 to 2018, ACC from King Chulalongkorn Memorial Hospital Phramongkutklao were enrolled into Clinical presentations hormonal profiles recorded. Mutation analyses of TP53 gene acquired using next-generation-sequencing method which performed for samples all patients parents those who tested...