A5100381410- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Biomarkers in Disease Prognosis
- Cholinesterase and Neurodegenerative Diseases
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cannabis and Cannabinoid Research
- Digestive system and related health
- Mycobacterium research and diagnosis
- Pregnancy-related medical research
- Drug-Induced Hepatotoxicity and Protection
- Glioma Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2025
Chongqing Medical University
2020-2025
Children's Hospital of Chongqing Medical University
2023-2025
First Affiliated Hospital of Gannan Medical University
2023
Peking University
2008-2019
Tianjin Nankai Hospital
2019
Tianjin Medical University
2009-2019
Peking University International Hospital
2019
Peking University First Hospital
2008-2018
Ruijin Hospital
2018
Insulin resistance (IR) is a critical factor of the pathophysiology Gestational diabetes mellitus (GDM). Studies on key organs involved in IR, such as livers and adipose tissues, showed that Toll-like receptor 4 (TLR4) can regulate insulin sensitivity. As maternal-fetal interface with multi-functions, placentae could contribute to development IR for GDM. Thus, we investigated expressions TLR4/Myeloid Differentiation 88 (MyD88)/Nuclear Factor kappa-light-chain-enhancer activated B cells...
To determine the longitude lipid profiles in women with and without gestational diabetes mellitus (GDM), to investigate relationship between disturbances 1st trimester GDM.Blood samples were collected from 1283 normal pregnant 300 GDM. Serum lipids which include total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL-C), high-density (HDL-C) measured TG/HDL-C ratio was calculated 1st, 2nd, 3rd trimesters of pregnancy then we got longitudinal profiles. We compared...
Aims: Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in the placenta, mild antioxidants failed prevent PE clinical trials. As mitochondria are a major source of OS, this study assessed potential potent mitochondria-targeting antioxidant MitoQ prevention PE. Results: Placentas from women with and reduced uterine perfusion pressure (RUPP) mice demonstrated significantly higher along increased mitochondrial damage compromised glutathione peroxidase (GPx)...
Disturbances in maternal lipid metabolism have been shown to increase the risk of adverse pregnancy outcomes. However, there is no consensus as what constitutes normal values during pregnancy. Thus, aim this study was establish serum reference ranges early and middle pregnancy.We conducted a retrospective survey Beijing from 2013 2014. A total 17,610 singleton pregnancies with data were included. First, after excluding women outcomes, we performed descriptive analysis cholesterol (TC),...
Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it reported that placentas of women with pregnancies complicated FGR exhibit peroxisome proliferator-activated receptor γ (PPARγ) inactivation. In mice, trophoblast-specific ablation murine PPARγ reproduces phenotype human fetuses defective adipogenesis. Coculture trophoblasts preadipocytes significantly improves preadipocyte...
Ticlopidine exerts its anti-platelet effects mainly by antagonizing platelet p2y12 receptors. Previously, a few studies have shown that ticlopidine can induce liver injury, but the exact mechanism of hepatotoxicity remains unclear. Oxidative stress, metabolic disorders, hepatocyte apoptosis, lipid peroxidation, and inflammatory responses all lead to hepatic damage, which cause hepatotoxicity. In this study, in order deeply explore potential molecular mechanisms -induced hepatotoxicity, we...
Syncytiotrophoblasts form via mononuclear cytotrophoblast fusion during placentation and play a critical role in maternal-fetal communication. Impaired syncytialization inevitably leads to pregnancy-associated complications, including preeclampsia. Endoplasmic reticulum stress (ERS) is reportedly linked with preeclampsia, but little known about its association syncytialization. High temperature requirement factor A4 (HtrA4), placental-specific protease, responsible for protein quality...
Spontaneous preterm delivery (SPTD) with gestational age between 28 and 37 complete weeks was reported to have a genetic predisposition in lipids metabolism. This study aimed investigate the association lipid levels gene polymorphisms of ABCA1 (rs2422493), APOE (rs7412) HMGCR (rs12916) Chinese pregnant women SPTD. A case-control conducted at baseline randomization 200 SPTD 178 healthy full term (FTD) women. Maternal blood were detected close fetus group FTD age-matched. Cord after two...
The objective was to study the effect of mechanical intestinal obstruction in rats on phenotype interstitial cells Cajal (ICC). Healthy Wistar were randomly divided into sham-operation group (C), one day (M1), two days (M2), and three (M3), with 10 each group. expression SCF mRNA c-Kit protein tissue investigated by RT-PCR immunohistochemistry. Compared group, relative significantly decreased both groups. Levels gradually prolongation time, 3rd after (P<0.05). Immunohistochemical staining...
15.3%), Henoch-Scho ¨nlein purpura glomerulonephritis (PN,10.2%),hypertension/ malignant hypertension-associated nephropathy (HTN, 9.1%) and HBV-related (HBV-GN, 7.4%).The spectrum of biopsy-proven kidney disease in the elderly patients varied between three different periods ((July 1987-June 1997 vs. July 1997-June 2007 2007-June 2017, P¼0.018).The prevalence iMN increased significantly (8.3% 25.2%vs.39.0%,P<0.001), while that MsPGN (25.0% 10.7% vs.4.2%,P <0.001) HTN 5.0% vs.1.2%,P<0.001)...